Investigating the Effect of Fennel and Cinnamon Combined Extract on Spermatogenesis and Testis Tissues in Busulfan Induced Infertile Rats

Chegini, R; Soleimani, Pouria; Sadeghi, Morteza; Yosef, Rana Mohammad; Zafari, Fariba

doi:10.29252/jabr.06.03.03

Cited by 4 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Shen et al (2002) attributed the protective effect of C. zeylanicum to the volatile oils in the bark, leaf and root. Chegini et al (2019) reported that cinnamon act as an antioxidant in food increase the antioxidant enzymes and it eliminate the reactive oxygen species so it restored fertility through normal spermatogenesis and improve testosterone level and sperm population and motility. Herbal antioxidants eliminate and suppress reactive oxygen species formation and the reduction of ROS is a crucial factor in the production of sperm cells and optimization of the fertility rate.…”

Section: Discussionmentioning

confidence: 99%

“…(2002) attributed the protective effect of C. zeylanicum to the volatile oils in the bark, leaf and root. Chegini et al. (2019) reported that cinnamon act as an antioxidant in food increase the antioxidant enzymes and it eliminate the reactive oxygen species so it restored fertility through normal spermatogenesis and improve testosterone level and sperm population and motility.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED: Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies

Arisha

Sakr

Abd-Elhaseeb

2020

Heliyon

View full text Add to dashboard Cite

Hyperlipidemia has been related to sever health outcome include cardiovascular complication, metabolic disorders and infertility. Moreover, obesity has also been linked to dangerous effects on testicular morphology, spermatogenesis and sperm malformation. Many studies using different herbal medicines exert protective and therapeutic effect on the testes, spermatogenesis and fertility in animals fed high fat diet. Objective: this study aimed to find out the protective effect of cinnamon on testes of albino rat fed high fat diet (HFD). Forty adult male albino rats were selected and equally divided into 4 groups. Group 1: animals of this group were fed standard diet. Group 2: rats were fed standard diet and cinnamon "15% weight by weight, w/w" for 8 weeks. Group 3: animals in this group were fed HFD (2% cholesterol, 15 % sucrose, 15% corn, 15% cocoa butter, starch and 4.7% cellulose) for 8 weeks. Group 4: animals in this group were fed HFD and cinnamon. At the end of 4 weeks half animals were sacrificed and the rest of animals were sacrificed at the end of 8 weeks and blood samples were collected to assay the testosterone level. As well as testes were taken and prepared for both histological and ultrastructure studies. Histological examination of testicular tissue of HFD-fed animals revealed many pathological changes include degenerated seminiferous tubules, distorted germinal layers and interstitial tissue appeared degenerated with intertubular hemorrhage. Ultrastructural observations showed severe degenerated features including both different types of spermatogonia and interstitial tissue. On the other hand, both histological and ultrastructural alterations were substantially but not completely protect in obese animals fed HFD and cinnamon for 4 weeks while advanced degree of improvement tissue appeared after 8 weeks of the same treatment. As well as, significantly increase in the level of testosterone was recorded when compared with HFD-fed animals. The present work concluded that cinnamon dietary uptake may improve testicular damage induced by HFD as it has anti-inflammatory, anti-obesity and antioxidant activities.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

RETRACTED: Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies

Arisha

Sakr

Abd-Elhaseeb

2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…In other studies, purslane extract increased activity levels of superoxide dismutase (SOD) and decreased levels of malondialdehyde (MDA) in an ulcerative colitis mouse model [ 22 ]. F. vulgare mill, also known as fennel, is an aromatic Mediterranean plant that has received much attention in traditional medicine [ 23 , 24 ]. This medicinal plant has diuretic, analgesic, anti-inflammatory, antipyretic, and antioxidant activity [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of purslane (Portulaca oleracea) and fennel (Foeniculum vulgare Mill) hydroalcoholic extracts on the functional parameters of human spermatozoa after vitrification

Torkamanpari

Ghorbani

Lorian

et al. 2023

Clin Exp Reprod Med

View full text Add to dashboard Cite

Objective: Reactive oxygen species (ROS) are produced during cryopreservation of human sperm and impair sperm function. Antioxidant compounds, such as fennel and purslane, reduce the damaging effects of ROS. This study aimed to evaluate motility parameters, plasma membrane integrity (PMI), mitochondrial membrane potential (MMP), intracellular ROS, and DNA damage to determine the optimum concentrations of hydroalcoholic extracts of fennel and purslane for human spermatozoa cryopreservation. Methods: Twenty human sperm samples were used and divided into seven equal groups consisting of fennel hydroalcoholic extract (5, 10, and 15 mg/L), purslane hydroalcoholic extract (25, 50, and 100 mg/L), and no additive. Results: Supplementation of 25 mg/L and 50 mg/L purslane extract and 10 mg/L fennel extract in cryopreservation extender significantly increased the motility and PMI of sperm with a significant reduction in intracellular ROS compared to control groups (p<0.05). A 50 mg/L concentration of purslane extract elevated progressive motility and MMP compared to the control group (p<0.05). No significant differences were seen for motion patterns and DNA damage of frozen–thawed human sperm in extender containing these extracts. Conclusion: The results showed that supplementation of 50 mg/L purslane extract and 10 mg/L fennel extract in semen cryopreservation extender has the potential to decrease intracellular ROS and subsequently elevate the motility and PMI of human sperm.

show abstract

Antioxidant and antiapoptotic paracrine effects of mesenchymal stem cells on spermatogenic arrest in oligospermia rat model

Zickri

Moustafa

Fasseh

et al. 2021

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

Investigating the Effect of Fennel and Cinnamon Combined Extract on Spermatogenesis and Testis Tissues in Busulfan Induced Infertile Rats

Cited by 4 publications

References 23 publications

RETRACTED: Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies

RETRACTED: Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies

The effects of purslane (Portulaca oleracea) and fennel (Foeniculum vulgare Mill) hydroalcoholic extracts on the functional parameters of human spermatozoa after vitrification

Antioxidant and antiapoptotic paracrine effects of mesenchymal stem cells on spermatogenic arrest in oligospermia rat model

Contact Info

Product

Resources

About