Investigating In Vitro and In Vivo Anti-Tumor Activity of Curvularia-Based Platinum Nanoparticles

Bhattacharya, Sonali; Halder, Madhusree; Sarkar, Arnab; Pal, P. C.; Das, Asim K.; Kundu, Susmita; Mandal, Deba Prasad; Bhattacharjee, Shamee

doi:10.1615/jenvironpatholtoxicoloncol.2022039940

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…Various research display anticancer activity in vitro against HeLa cells [ 85 , 91 , 152 ], HEK293 cells [ 137 , 153 ], MCF-7 (breast cancer) and HepG-2 (hepatocellular carcinoma) [ 32 , 49 , 103 , 104 , 142 ], MDA-MB-231 breast cancer cell line [ 154 ], lung carcinoma cells A549 [ 102 , 131 ], SH-SY5Y cells [ 132 ], ovarian teratocarcinoma (PA-1), pancreatic cancer(Mia-Pa-Ca-2) cells [ 16 ], colon carcinoma cells (HCT-116) [ 90 ], sarcoma-180 (S-180) cells [ 155 ], 4T1 breast cancer cells [ 156 ], A431 cell lines (epidermoid carcinoma) [ 55 ] and myoblast C2C12 carcinoma cells [ 144 ].…”

Section: Application Of Green Ptnpsmentioning

confidence: 99%

“…No significant cytotoxic effect in vitro was observed in the normal PBMC (Peripheral blood mononuclear cells) at the highest concentration (200 μg/mL), but ptNPs induced cell death in ovarian, lung and pancreatic cancer cell lines; additionally, the nanoparticle cytotoxicity was dependent on the cell type [ 16 ]. Antitumor activity was determined for Curvularia -based platinum nanoparticles, but with subchronic exposure (3 months) they did not have significant toxicological manifestations of renal and hepatic tissue, and also decreased oxidative stress and improved liver function in mice with tumors compared with untreated control groups [ 155 ]. Pr.…”

Section: Toxicology Of «Green» Platinum Nanoparticlesmentioning

confidence: 99%

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Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Михайлова¹

2022

JFB

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The diverse biological properties of platinum nanoparticles (PtNPs) make them ideal for use in the development of new tools in therapy, diagnostics, and other biomedical purposes. “Green” PtNPs synthesis is of great interest as it is eco-friendly, less energy-consuming and minimizes the amount of toxic by-products. This review is devoted to the biosynthesis properties of platinum nanoparticles based on living organisms (bacteria, fungi, algae, and plants) use. The participation of various biological compounds in PtNPs synthesis is highlighted. The biological activities of “green” platinum nanoparticles (antimicrobial, anticancer, antioxidant, etc.), the proposed mechanisms of influence on target cells and the potential for their further biomedical application are discussed.

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Section: Application Of Green Ptnpsmentioning

confidence: 99%

Section: Toxicology Of «Green» Platinum Nanoparticlesmentioning

confidence: 99%

Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Михайлова¹

2022

JFB

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“…Silver nanoparticle synthesized from Curvularia affinis Boedjin is a good nanofungicide as it inhibits the growth of the fungal pathogen Alternaria solani (Madhusree et al, 2018 ). Platinum nanoparticles (PtNPs) synthesized from Curvularia affinis Boedjin have significant anti-proliferative and pro-apoptotic activities in sarcoma-180 cells, and can apply as a potent anti-tumor drug (Bhattacharya et al, 2022 ).…”

Section: As a Source For Myconanosynthesismentioning

confidence: 99%

Bioactive compounds of Curvularia species as a source of various biological activities and biotechnological applications

2022

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Many filamentous fungi are known to produce several secondary metabolites or bioactive compounds during their growth and reproduction with sort of various biological activities. Genus Curvularia (Pleosporaceae) is a dematiaceous filamentous fungus that exhibits a facultative pathogenic and endophytic lifestyle. It contains ~213 species among which Curvularia lunata, C. geniculata, C. clavata, C. pallescens, and C. andropogonis are well-known. Among them, C. lunata is a major pathogenic species of various economical important crops especially cereals of tropical regions while other species like C. geniculata is of endophytic nature with numerous bioactive compounds. Curvularia species contain several diverse groups of secondary metabolites including alkaloids, terpenes, polyketides, and quinones. Which possess various biological activities including anti-cancer, anti-inflammatory, anti-microbial, anti-oxidant, and phytotoxicity. Several genes and gene factors are involved to carry and regulate the expression of these activities which are influenced by environmental signals. Some species of Curvularia also show negative impacts on humans and animals. Apart from their negative effects, there are some beneficial implications like production of enzymes of industrial value, bioherbicides, and source of nanoparticles is reported. Many researchers are working on these aspects all over the world but there is no review in literature which provides significant understanding about these all aspects. Thus, this review will provide significant information about secondary metabolic diversity, their biological activities and biotechnological implications of Curvularia species.

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“…Furthermore, in vitro and in vivo studies have shown anti-cancer effects of PtNPs 8 . They destroy cells and alleviate oxidative stress by scavenging free radicals 9 , 10 . Modifying the surface of NPs is a promising approach to increase their therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

Bio synthesis, comprehensive characterization, and multifaceted therapeutic applications of BSA-Resveratrol coated platinum nanoparticles

Faisal,

Tariq,

Abdullah

et al. 2024

Sci Rep

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This study examines the manufacturing, characterization, and biological evaluation of platinum nanoparticles, which were synthesized by Enterobacter cloacae and coated with Bovine Serum Albumin (BSA) and Resveratrol (RSV). The formation of PtNPs was confirmed with the change of color from dark yellow to black, which was due to the bioreduction of platinum chloride by E. cloacae. BSA and RSV functionalization enhanced these nanoparticles' biocompatibility and therapeutic potential. TGA, SEM, XRD, and FTIR were employed for characterization, where PtNPs and drug conjugation-related functional groups were studied by FTIR. XRD confirmed the crystalline nature of PtNPs and Pt-BSA-RSV NPs, while TGA and SEM showed thermal stability and post-drug coating morphological changes. Designed composite was also found to be biocompatible in nature in hemolytic testing, indicating their potential in Biomedical applications. After confirmation of PtNPs based nanocaompsite synthesis, they were examined for anti-bacterial, anti-oxidant, anti-inflammatory, and anti-cancer properties. Pt-BSA-RSV NPs showed higher concentration-dependent DPPH scavenging activity, which measured antioxidant capability. Enzyme inhibition tests demonstrated considerable anti-inflammatory activity against COX-2 and 15-LOX enzymes. In in vitro anticancer studies, Pt-BSA-RSV NPs effectively killed human ovarian cancer cells. This phenomenon was demonstrated to be facilitated by the acidic environment of cancer, as the drug release assay confirmed the release of RSV from the NP formulation in the acidic environment. Finally, Molecular docking also demonstrated that RSV has strong potential as an anti-oxidant, antibacterial, anti-inflammatory, and anticancer agent. Overall, in silico and in vitro investigations in the current study showed good medicinal applications for designed nanocomposites, however, further in-vivo experiments must be conducted to validate our findings.

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Investigating In Vitro and In Vivo Anti-Tumor Activity of Curvularia-Based Platinum Nanoparticles

Cited by 5 publications

References 40 publications

Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Bioactive compounds of Curvularia species as a source of various biological activities and biotechnological applications

Bio synthesis, comprehensive characterization, and multifaceted therapeutic applications of BSA-Resveratrol coated platinum nanoparticles

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