Throughout history, disease outbreaks have worked havoc upon humanity, sometimes reorienting the history and at times, signaling the end of entire civilizations and the modern pandemic that the world is dealing with, is COVID-19 or SARS-CoV-2. A healthy immunity could be an ideal gear for resisting COVID-19 for neither medicines nor vaccines have been ascertained till date. In view of the present scenario, there is a demanding necessity to analyze innovative and valid techniques for forestalling and cure of COVID-19 by re-evaluating the structure of the natural compounds for drug designing. The Ayurveda has come forward by prescribing a lot of medicinal herbs for combating this dreaded disease. We have searched from sources in Pubmed and Google Scholar and found 1509 items. The search criteria were limited to the effect of phytochemicals in certain immunomodulatory aspects of viral infection. The original research papers related to the works on phytochemicals in the down regulation of NF-kB, activation of NK and CD8? cells, inhibition of inflammatory cytokine release and ROS scavenging were included in our study. Here, we try to focus on the immunoregulatory cells which have a vital aspect in COVID-19 and highlight the potential effects of the restorative use of phytochemicals as drugs or dietary supplements.
Paracetamol is a popular and safe drug preferred by victims of pain or pyrexia; however, its overdose or abuse is a growing concern worldwide. Here the hepatoprotective effect of an ethnomedicinal plant Drynaria quercifolia against paracetamol-induced toxicity in murine model is demonstrated. This fern, native to tropical countries including the Northeast India, is used by local tribes to treat infl ammatory conditions. Paracetamol 500 mg/kg body weight was orally administered on alternate days for a period of 21days to mimic a chronic overdose. Drynaria quercifolia acetone extract (DQA) treatment interspaced with paracetamol signifi cantly decreased serum biomarkers of hepatotoxicity (ALT, AST and ALP) renal toxicity (urea, creatinine), lipid peroxidation level, histological damage in liver and kidney. The protein and mRNA expressions of the transcription factor, Nrf2, and its target antioxidant genes (SOD1, CAT and GST) as well as activities of these antioxidant enzymes were downregulated by paracetamol administration but signifi cantly recovered following the DQA treatment (Tab.
<p>Qualitative research was undertaken
(Creswell, J. W. 2013), content analysis was conducted on the video data and
newspaper data, the data were available in public domain and open for all. Phenomenological
research methodology (Moustakas, C. 1994) was adopted to understand the
commonality of lived experience of migrant workers regarding what they
experienced after lockdown, as the migrant workers shared the lived experiences
on video camera to the reporters of news channels. The goal of this phenomenological
approach was to arrive at the nature of the description of the phenomenon
(Morrow, R., Rodriguez, A., & King, N. 2015), that they were experiencing
on the ground (Creswell, 2013). Codes were identified and themes were found
from the data. Due to lockdown, author could not go out in the field to speak
to these migrant workers and collect primary data, hence the rich data
available in the field in the form of videos captured by different news
channels, and also some newspaper reports, which were available in public
domain open to all, were utilised. Migrant workers communicated in native Hindi
language; as reporters spoke to them and interviewed them (Bevan, M. T. (2014).
The author well conversant with native Hindi language could understand the
language well and could translate it in meaningful English language. To ensure
the accuracy, it was also got checked by one more expert. </p>
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