Inverse supercritical extraction of acetaminophen from suppositories

Determination of ten steroid hormones in animal waste manure and agricultural soil using inverse and integrated clean-up pressurized liquid extraction and gas chromatography-tandem mass spectrometry

“…Such strategies have previously been applied in supercritical fluid extraction (SFE) within pharmaceutical analysis, there called inverse SFE. [22][23][24][25][26] A single paper has been published utilizing PLE for the removal of fat from pork with pure hexane prior to extraction of the analytes of interest (barbiturates). 27 The second step during our method development was to perform ic-PLE 10 by connecting an additional cell downstream of the extraction cell by means of a custom made cell coupling module.…”

Optimisation and validation of a rapid and efficient microemulsion liquid chromatographic (MELC) method for the determination of paracetamol (acetaminophen) content in a suppository formulation

“…The target of this study, a paracetamol suppository was chosen because suppositories generally require a number of sample extraction and/or pre-treatment steps before the analysis can be performed [7][8][9]11] due to the hydrophobic bulk ingredient in the preparation. Sample preparation was shown to be extremely rapid compared to the reference method and required a single step of dissolving the suppository sample in the microemulsion.…”

“…Various methods such as calorimetry [7], spectrophotometry [8] and HPLC with inverse supercritical extraction [9] have been reported for the assay of paracetamol in suppositories. The latter method reported an improvement in analysis times compared to US Pharmacopoeia (1998) [10] method but still required a number of time consuming extraction steps before HPLC analysis was possible.…”

Focused microwave-assisted extraction and LC determination of the active ingredient in naproxen-based suppositories

“…Among non-conventional methods for suppositories treatment before active ingredient chromatographic determination the use of supercritical CO 2 for the isolation of acetaminophen from suppositories has been described [26].…”