Focused microwave-assisted extraction and LC determination of the active ingredient in naproxen-based suppositories

Labbozzetta, Stefano; Valvo, Luisa; Bertocchi, Paola; Manna, Livia

doi:10.1016/j.jpba.2005.04.020

Cited by 18 publications

(7 citation statements)

References 25 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MW energy, ranging from 1.24 × 10 −6 to 1.24 × 10 −3 eV, acts as a nonionizing radiation that does not affect molecular structure since it is lower than the usual ionization energies of biological compounds (13.6 eV), bond energies (2–5 eV) and van der Waals intermolecular interactions (<2 eV) . The effect of MW on chemical synthesis and extraction processes is strictly related to the conversion of electromagnetic energy to heat; in controlled systems, high radiation intensity failed to show any other significant athermal or specific effects induced by microwave radiation …”

Section: Fundamentals Of Microwave Heatingmentioning

confidence: 99%

“…In conventional processes, heat is transferred by convection and conduction, whereas microwaves penetrate into the solid at the speed of light, causing direct generation of heat within the material and a simultaneous temperature rise . By adjusting microwave output, the amount of heat energy generated inside the solid can be controlled and heating can be relatively uniform.…”

Section: Mechanism Of Microwave Assisted Water Extraction Of Plant Comentioning

confidence: 99%

“…The application of microwave energy may be performed operating in: (i) pressurized equipments, under controlled temperature in a high‐pressure closed container where solvent is heated above its boiling point; or (ii) open‐systems at atmospheric pressure . The advantages of each are listed in Table .…”

Section: Types Of Technologies Used In Microwave Assisted Water Extramentioning

confidence: 99%

See 2 more Smart Citations

Microwave assisted water extraction of plant compounds

Flórez

Conde

Domı́nguez

2014

J of Chemical Tech & Biotech

188

124

View full text Add to dashboard Cite

The development of environmentally friendly processes with limited generation of polluting streams to attain sustainable utilization of raw materials is encouraged. The implementation of novel extraction technologies more efficient, selective and with lower energy consumption than conventional ones, can help in achieving this objective. Particularly promising are aqueous based methods, since water is a cheap, safe and abundant solvent and the limited use of toxic organic solvents is a consumeŕs, ecological and processing demand. The benefits and the limiting aspects of microwave assisted water extraction, either adding water as the only solvent or in solvent free processes, using the naturally present water in vegetal materials for the extraction of valuable components from renewable vegetal sources are highlighted and the potential of this technique for industrial applications is discussed.Microwaves (MW) are radiation of the electromagnetic spectrum ranging in frequency from 300 MHz (radio radiation) to 300 GHz J Chem Technol Biotechnol 2015; 90: 590-607

show abstract

Section: Fundamentals Of Microwave Heatingmentioning

confidence: 99%

Section: Mechanism Of Microwave Assisted Water Extraction Of Plant Comentioning

confidence: 99%

Section: Types Of Technologies Used In Microwave Assisted Water Extramentioning

confidence: 99%

See 1 more Smart Citation

Microwave assisted water extraction of plant compounds

Flórez

Conde

Domı́nguez

2014

J of Chemical Tech & Biotech

188

124

View full text Add to dashboard Cite

show abstract

“…The sustainability of the proposed process is promising when compared to others reported in literature. Some processes were suggested aimed at recovering naproxen, ketoprofen, and ibuprofen from pharmaceutical formulations, e.g., suppositories, topical creams, and tablets. Even though speeding up the recovery process, the use of microwave-assisted methods, e.g., microwave irradiation of 2450 MHz, , and/or high temperatures (≥35 °C, 65 °C, and 70 °C) generate high energetic inputs.…”

Section: Resultsmentioning

confidence: 99%

Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems

Silva

Caban

Kholany

et al. 2018

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Aiming at outlining new strategies for the valorization of solid pharmaceutical wastes as viable alternatives to incineration, this work proposes the use of ionic liquids-based three phase partitioning (IL-based TPP) systems. Ibuprofen, naproxen, and ketoprofen, all belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), were adopted as model compounds. An integrated process has been conceptualized based on three steps: (1) extraction and purification of NSAIDs using the IL-based TPP systems, (2) drug isolation by precipitation with antisolvents, and (3) recycling and reusing the solvents. With the optimization of steps 1 and 2 as objects of this investigation, aqueous biphasic systems (ABS) composed of three distinct ILs (tetrabutylammonium chloride, 1-butyl-3-methylimidazolium chloride, and benzyldimethyl(2-hydroxyethyl)ammonium chloride) and potassium citrate buffer were studied. The corresponding IL-based TPP systems were further applied in the purification of each NSAID, and different antisolvents (citric acid aqueous solutions for ibuprofen and naproxen and aluminum sulfate aqueous solutions for ketoprofen) were evaluated as precipitating agents to isolate each drug. The success of the process developed is demonstrated by extraction efficiencies higher than 83.8 ± 7.7% attained in step 1 and isolation efficiencies higher than 76.2 ± 1.8% in step 2. The stability of the three NSAIDs in IL-based aqueous matrices was additionally checked by using a protocol adapted from the OECD guidelines. The economic efficiency and environmental benignity of the process herein developed is underlined, based on not only the low cost of the solvents chosen but also the possibility of recycling and reusing the phase-forming components and antisolvents employed.

show abstract

“…If MAE is performed in closed vessels, extractions can be carried out at temperatures above the boiling point of the solvent, thus increasing extraction speed and efficiency. Also, MAE requires much lower volume of organic solvent, reduces extraction time and allow the preparation of multiple samples in one step [23,24]. Some parameters can affect MAE, such as extraction time, solvent volume, temperature and organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction for the Determination of Glycyrrhizin in Menthazin Herbal Drug by Experimental Design Methodology

Talebpour

Ghassempour

Abbaci

et al. 2009

Chroma

View full text Add to dashboard Cite

In the present study, a microwave-assisted extraction (MAE) method has been investigated for the extraction of glycyrrhizin from Menthazin herbal drug. The extracted samples have been analyzed by a developed reversed-phase liquid chromatography with ultraviolet detection. The separation was performed by a Eurospher-100 C 8 reversed-phase column (250 9 4.6 mm i.d., 5 lm) and the mobile phase consisted of methanol:acetonitrile:water:glacial acetic acid (30:30:40:1 v/v/v/v) with a flow rate of 0.8 mL min -1 . The extraction procedure has been screened by a two level full factorial design for determination of statistically significant parameters. Thereafter, the identified parameters, extraction temperature, time and solvent volume were optimized by a Box-Behnken design. The proposed mathematical model was based on analysis of variance results and correctly explained the behavior of the response in the experimental domain. R 2 value adjusted for numbers of degrees of freedom was 0.9915 and P-value for lack of fit, 0.8499 at the 95% confidence level, P > 0.05. The optimal condition identified were extraction temperature, 70°C, time, 13.8 min and solvent volume 2.0 mL. To evaluate the applicability of the proposed MAE method, results were compared with those obtained with the liquid extraction method. Extraction efficiency and precision were higher when MAE has been used. The proposed method allows extracting the glycyrrhizin in a small quantity of solvent and faster than the liquid extraction method. KeywordsColumn liquid chromatography Microwave-assisted extraction Experimental design Box-Behnken design Glycyrrhizin

show abstract

Focused microwave-assisted extraction and LC determination of the active ingredient in naproxen-based suppositories

Cited by 18 publications

References 25 publications

Microwave assisted water extraction of plant compounds

Microwave assisted water extraction of plant compounds

Recovery of Nonsteroidal Anti-Inflammatory Drugs from Wastes Using Ionic-Liquid-Based Three-Phase Partitioning Systems

Optimization of Microwave-Assisted Extraction for the Determination of Glycyrrhizin in Menthazin Herbal Drug by Experimental Design Methodology

Contact Info

Product

Resources

About