Optimisation and validation of a rapid and efficient microemulsion liquid chromatographic (MELC) method for the determination of paracetamol (acetaminophen) content in a suppository formulation

McEvoy, Eamon; Donegan, Sheila; Power, Joe; Altria, Kevin D.

doi:10.1016/j.jpba.2007.02.025

Cited by 65 publications

(10 citation statements)

References 10 publications

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“…SD Sa is the standard deviation of the intercept and Sb is the slope (McEvoy et al, 2007). Accuracy was defined as the percentage of the systematic error, which is determined as standardized agreement between the measured value and the true value (relative error < 10%).…”

Section: Dose Content and Quantification Methodsmentioning

confidence: 99%

Design and physicochemical stability studies of paediatric oral formulations of sildenafil

Provenza¹,

Calpena²,

Mallandrich³

et al. 2014

International Journal of Pharmaceutics

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Personalized medicine is a challenging research area in paediatric treatments. Elaborating new paediatric formulations when no commercial forms are available is a common practice in pharmacy laboratories; among these, oral liquid formulations are the most common. But due to the lack of specialized equipment, frequently studies to assure the efficiency and safety of the final medicine cannot be carried out. Thus the purpose of this work was the development, characterization and stability evaluation of two oral formulations of sildenafil for the treatment of neonatal persistent pulmonary hypertension. After the establishment of a standard operating procedure (SOP) and elaboration, the physicochemical stability parameters appearance, pH, particle size, rheological behaviour and drug content of formulations were evaluated at three different temperatures for 90 days. Equally, prediction of long term stability, as well as, microbiological stability was performed. Formulations resulted in a suspension and a solution slightly coloured exhibiting fruity odour. Formulation I (suspension) exhibited the best physicochemical properties including Newtonian behaviour and uniformity of API content above 90% to assure an exact dosification process.

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Section: Dose Content and Quantification Methodsmentioning

confidence: 99%

Design and physicochemical stability studies of paediatric oral formulations of sildenafil

Provenza¹,

Calpena²,

Mallandrich³

et al. 2014

International Journal of Pharmaceutics

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show abstract

“…Microemulsion liquid chromatography (MELC) is a relatively new chromatographic technique that uses a microemulsion as a mobile phase using conventional columns. MELC has been used for the separation of mixtures of test solutes or pharmaceutical compounds by an isocratic system (Berthod and De, ; El‐Sherbiny et al ., ; Jančić et al ., ), and for the investigation of drugs in their pharmaceutical preparations (McEvoy et al ., ; Momenbeik et al ., ; Althanyan et al ., ) or in biological samples (Jancic et al ., ; Walash et al ., ). Recently, MELC has also been used to mimic several biologically important processes (Liu et al ., ) and predict the n‐ octanol–water partition coefficient (Li et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Determination of the lipophilicity of Salvia miltiorrhiza Radix et Rhizoma (danshen root) ingredients by microemulsion liquid chromatography: optimization using cluster analysis and a linear solvation energy relationship‐based method

Yang

Huang

et al. 2015

Biomedical Chromatography

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We evaluated 26 microemulsion liquid chromatography (MELC) systems for their potential as high-throughput screening platforms capable of modeling the partitioning behaviors of drug compounds in an n-octanol-water system, and for predicting the lipophilicity of those compounds (i.e. logP values). The MELC systems were compared by cluster analysis and a linear solvation energy relationship (LSER)-based method, and the optimal system was identified by comparing their Euclidean distances with the LSER coefficients. The most effective MELC system had a mobile phase consisting of 6.0% (w/w) Brij35 (a detergent), 6.6% (w/w) butanol, 0.8% (w/w) cyclohexane, 86.6% (w/w) buffer solution and 8 mm cetyltrimethyl ammonium bromide. The reliability of the established platform was confirmed by the agreement between the experimental data and the predicted values. The logP values of the ingredients of danshen root (Salvia miltiorrhiza Radix et Rhizoma) were then predicted. Copyright © 2015 John Wiley & Sons, Ltd.

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“…Biopartitioning chromatography (BPC) was developed as an extension of conventional HPLC, and represents a novel HTS platform for the rapid evaluation of large compound libraries in terms of their drug membrane permeability properties. BPC is a generic name for micellar and microemulsion electrokinetic chromatography (MEKC and MEEKC) [7], as well as micellar and microemulsion liquid chromatography (MLC and MELC) [8][9][10][11][12]. Among these chromatographic systems, the use of microemulsion mobile phases in MELC provides several advantages in terms of predicting the drug membrane permeability properties.…”

Section: Introductionmentioning

confidence: 99%

Determination of the lipophilicity (logPo/w) of organic compounds by microemulsion liquid chromatography

Huang

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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Optimisation and validation of a rapid and efficient microemulsion liquid chromatographic (MELC) method for the determination of paracetamol (acetaminophen) content in a suppository formulation

Cited by 65 publications

References 10 publications

Design and physicochemical stability studies of paediatric oral formulations of sildenafil

Design and physicochemical stability studies of paediatric oral formulations of sildenafil

Determination of the lipophilicity of Salvia miltiorrhiza Radix et Rhizoma (danshen root) ingredients by microemulsion liquid chromatography: optimization using cluster analysis and a linear solvation energy relationship‐based method

Determination of the lipophilicity (logPo/w) of organic compounds by microemulsion liquid chromatography

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