Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women

Abstract

Background: Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects. Objective: To characterize the relationship between adiponectin and leptin, the ob gene product, in normal-weight and obese women. Design and methods: In this cross-sectional study, we measured fasting plasma adiponectin by ELISA, leptin concentrations by RIA, and related parameters such as blood pressure, body mass index (BMI), body fat mass, lipids, fasting blood glucose and insulin in 353 non-diabetic adult women with a wide range of BMI values. Results: Plasma adiponectin concentrations in women with the highest tertile of BMI (at least 25.0 kg/m

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

“…In our sample, adiponectin and leptin levels were slightly higher in girls than in boys, which is in accordance with the findings in children 3,19 and in adults, 4 reporting higher leptin levels in females than in males.…”

“…A distinct dimorphism can be found between boys and girls especially during progressive pubertal stages. Matsubara et al, 4 who investigated only obese women, reported that serum leptin concentrations are increased as a consequence of 'leptin resistance'. Levels of leptin are related to body fat mass and fat distribution, and they change during puberty.…”

Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adults

“…Inverse correlations were observed between adiponectin and WHtR as well as WHpR. This supports reports from other studies suggesting the relative distribution of body mass (as represented in this study by WC, WHtR, and WHpR) [37,38] and not simply increased relative adiposity (approximated using BMI). Conversely, leptin levels were positively correlated with BMI and WHtR but not WC or…”

“…This study found that the strongest correlation for adiponectin relating to glycaemic control was insulin (inverse), whilst no significant associations were identified with leptin in this area. Previous data have also identified positive correlations between adiponectin, glycaemic control [36], and insulin sensitivity [41], as well as inverse associations with HbA1c [9] and insulin resistance [37,38]. Cortisol [42] and insulin [42,43] have also been correlated with leptin expression and secretion.…”

Cord lining progenitor cells: potential in vitro adipogenesis model

“…Its plasma concentrations are X1000-fold higher than that of leptin, ranging from 1.9 to 17.0 mg ml À1 in healthy volunteers. 32,34,35 Körner et al demonstrated in human adipocyte cell culture that adiponectin synthesis and secretion occurred specifically in mature adipocytes. Therefore, adiponectin could serve as a distinctive marker of adipocyte differentiation.…”