Invasive Zygomycosis: Update on Pathogenesis, Clinical Manifestations, and Management

Kontoyiannis, Dimitrios P.; Lewis, Russell E.

doi:10.1016/j.idc.2006.06.003

Cited by 244 publications

(333 citation statements)

References 89 publications

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“…15,16 However, there is a concern that prior voriconazole use predisposes to zygomycosis. 13,17,18 Our data appear to support the suggestion of breakthrough zygomycosis.…”

Section: 04mentioning

confidence: 99%

Breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole

Trifilio

Singhal

Williams

et al. 2007

Bone Marrow Transplant

217

171

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Seventy-one allograft recipients receiving voriconazole, in whom complete clinical, microbiologic and pharmacokinetic data were available, were studied to determine the efficacy of voriconazole in preventing fungal infections. The length of voriconazole therapy was 6-956 days (median 133). The total number of patient-days on voriconazole was 13 805 (B38 years). A total of 10 fungal infections were seen in patients on voriconazole (18% actuarial probability at 1 year): Candida glabrataand Mucor (n ¼ 1). Two of the four zygomycosis cases were preceded by short durations of voriconazole therapy, but prolonged itraconazole prophylaxis. The plasma steady-state trough voriconazole levels around the time the infection occurred were o0.2, o0.2, 0.33, 0.55, 0.63 and 1.78 lg/ml in the six candidiasis cases. Excluding the four zygomycosis cases, all the six candidiasis cases were seen among the 43 patients with voriconazole levels of p2 lg/ml and none among the 24 with levels of 42 lg/ml (P ¼ 0.061). We conclude that voriconazole is effective at preventing aspergillosis. However, breakthrough zygomycosis is seen in a small proportion of patients. The role of therapeutic voriconazole monitoring with dose adjustment to avoid breakthrough infections with fungi that are otherwise susceptible to the drug needs to be explored prospectively.

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“…15,16 However, there is a concern that prior voriconazole use predisposes to zygomycosis. 13,17,18 Our data appear to support the suggestion of breakthrough zygomycosis.…”

Section: 04mentioning

confidence: 99%

Breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole

Trifilio

Singhal

Williams

et al. 2007

Bone Marrow Transplant

217

171

View full text Add to dashboard Cite

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“…The first case reported was a lady with caesarean section wound infected with mucormycosis. She was managed with anti-fungal medicine and surgical debridement [9]. Another study reported two cases of cutaneous R. arrhizus infection in which exposure to a karaya ostomy bag was determined to be the source of R. arrhizus infection in susceptible hosts.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Fasciitis Due to Rhizopus in Blast Injury Wound - An Unusual Life Threatening Situation

Khan¹,

Lalani²,

Ikram³

et al. 2017

Med Rep Case Stud

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“…Mucormycosis is the second most common fungal infection in diabetic patients after aspergillosis [5]. Mucormycosis is caused by subclass of Zygomycetes fungi.…”

Section: Discussionmentioning

confidence: 99%

“…Mucormycosis is an emerging fungal infection with a high rate of mortality. Mucormycosis is the term used to describe fungal infections caused by fungi in the order Mucorales, and species in the Mucor, genera rhizopus, absidia and cunninghamella are most often implicated [5]. This disease is often characterized by hyphae growing in and around vessels.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Facial Palsy Due to Mucormycosis

Shah¹,

Ganapathy²,

Gopalakrishnan³

et al. 2015

IJOHNS

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A very uncommon instance of facial nerve palsy involving isolated temporal bone with associated uncontrolled diabetes mellitus has been noticed. A 53-year-old diabetic male presented himself with facial asymmetry, ear pain, and discharge in the right ear of one-month duration. Clinical examination revealed grade IV [House-Brackmann] right sided facial palsy, and otoscopy of small central perforation. Clinically acute otitis media with facial palsy diagnosis was made. There was minimal response to medical treatment. As per CT scan and audiometry findings, patient was subjected for exploratory mastoidectomy showing pale granulation tissue involving geniculate ganglion of facial nerve. The histopathology was suggestive of mucormycosis, an unusual presentation in middle ear. The patient was treated with injectable Amphotericin B. This case highlights a rare cause of isolated facial palsy and physicians should be aware of such atypical clinical presentation.

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Invasive Zygomycosis: Update on Pathogenesis, Clinical Manifestations, and Management

Cited by 244 publications

References 89 publications

Breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole

Breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole

Necrotizing Fasciitis Due to Rhizopus in Blast Injury Wound - An Unusual Life Threatening Situation

A Rare Case of Facial Palsy Due to Mucormycosis

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