Inulin‐Based Hydrogel for Oral Delivery of Flutamide: Preparation, Characterization, and in vivo Release Studies

Abstract

The ability of a hydrogel obtained by crosslinking INUDV and PEGBa to facilitate sustained release of flutamide is examined. The hydrogel is prepared in pH = 7.4 PBS and no toxic solvents or catalysts are used. It is recovered in microparticulate form and its size distribution is determined. Mucoadhesive properties are evaluated in vitro by reproducing gastrointestinal conditions. Flutamide is loaded into the hydrogel using a post-fabrication encapsulation procedure that allows a drug loading comparable to that of market tablets. Drug-loaded microparticles are orally administered to cross-bred dogs and the in vivo study demonstrates their ability to prolong the half-life of the principal active metabolite approximately threefold and to significantly increase its bioavailability.

Synthesis and characterization of a novel inulin hydrogel crosslinked with pyromellitic dianhydride

“…This crosslinking of inulin resulted in new biomaterials that were exploited for drug delivery and biomedical applications encapsulating various drug molecules such as ibuprofen [40], diflunisal [34], 2-methoxyestradiol [41], flutamide [42], prednisolone [36], oxytocin and glutathione [39] and also proteins including immunoglobulin G (IgG) [33], bovine serum albumin and lysozyme [26] and the latter two examples exploiting inulin's unique properties for delivery to the colon.…”

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

“…It is water soluble and exhibits high hydroxyl functional groups available for common coupling reactions [24]. Various studies have dealt with its chemical modification in order to obtain biocompatible drug delivery systems (DDS), including hydrogels [25], nanoparticles [26], micelles [6] and [27], and macromolecular bioconjugates [28]. Being inulin versatile and highly functionalizable [29] and [30], here we focused our attention on the synthesis of an amphiphilic inulin derivative capable of coating SPIONs once placed in aqueous media.…”

Inulin and Its Application in Drug Delivery

“…Excellent or sufficient swelling is necessary for the enzyme’s degradation of hydrogel in the colon environment. Detection of fructose monomers as a degradation by-product from hydrogels prepared by Pitarresi et al [ 54 , 97 ] after incubation with colonic enzymes inulinase is another confirmation of the excellent biodegradability of inulin hydrogels.…”