Synthesis and characterization of a novel inulin hydrogel crosslinked with pyromellitic dianhydride

Abstract

Highlight  A novel hydrogel was obtained by esterification between inulin and PMDA in a one-pot synthesis  The physicochemical properties of the hydrogel were characterized using a range of techniques including Flory-Rehner theory to establish crosslinking density  Hydrogels with different crosslinking density were obtained by varying the ratio of PMDA to inulin in the esterification  The hydrogels demonstrated pH dependent swelling that was inversely proportional to the amount of PMDA

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

“…Figure 4a shows the thermogravimetric analysis of the polyol precursors, INU and PCL-diol. In the thermogram of INU, three characteristic thermal transitions are observed, the first from 25 to 180 • C related to moisture content of the sample, the second range from 180 to 240 • C corresponding to the initial inulin decomposition of the glycosidic linkages and followed to the last transition from 240 to 900 • C that goes from a continuous mass loss due to inulin decomposition and combustion [36,37]; and from the second (PCL-diol) it is seen only a single step thermal degradation corresponding to the backbiting of ester in a temperature range of 280 to 410 • C followed by the continuous decomposition and combustion of the sample [38].…”

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

“…It also received generally recognized as safe (GRAS) status by the Food and Drug Administration (FDA) due to its several outstanding properties including biodegradability, renewability, nontoxicity, etc., compared to many other polysaccharides as described in Fig. 6 ( Afinjuomo et al, 2019 ).

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“…Inulin is made up of d -fructose units that are linked by β-2,1 glycosidic bonds with a wide range of degrees of polymerization (between 2 and 60) and commonly combined with a glucose residue at the terminus ( López-Molina et al, 2015 ). In addition, inulin has received generally recognized as safe (GRAS) status by the Food and Drug Administration (FDA) due to its several outstanding properties including biodegradability, renewability, nontoxicity, etc., compared to those of many other polysaccharides ( Afinjuomo et al, 2019 ). It is an undigested polysaccharide and is classified as a dietary fiber that escapes small intestinal digestion but is degraded (partial or complete) by colonic microbiota.…”

“…Inulin, which was discovered as a fructan-type oligosaccharide, is distributed in more than 36,000 vegetables and herbs. Jerusalem artichokes, leeks, oats, onion, and garlic are abundant sources of inulin, while it is obtained commercially from members of the Asteraceae family, such as chicory ( Afinjuomo et al, 2019 ; Kokubun, Ratcliffe, & Williams, 2018 ). Inulin is made up of d -fructose units that are linked by β-2,1 glycosidic bonds with a wide range of degrees of polymerization (between 2 and 60) and commonly combined with a glucose residue at the terminus ( López-Molina et al, 2015 ).…”

Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery

“…For this reason, we hope to exploit the variation in the microflora concentration of various segments of the gastrointestinal tract for site-specific delivery of drugs to the colon. The chemical modification or derivatization of hydrophilic inulin results in new materials with hydrophobic characters making them suitable for drug delivery systems (DDSs), including hydrogels [16,17,18,19], micelles [20,21,22], liposomes [23], nanoparticles [24,25,26], vaccine adjuvants [27,28,29], solid dispersion [30,31], microparticles [8,12,32], and macromolecular bioconjugates/prodrugs [33,34]. To develop hydrogel drug delivery systems, different chemical strategies and techniques have been utilized for hydrogel synthesis.…”