Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Abstract

In this study, new polyurethanes (PUs) were prepared by using inulin and polycaprolactone as polyols. Their structure and morphology were determined by Fourier transform infrared spectroscopy (FTIR), Raman dispersive spectroscopy, Nuclear magnetic resonance spectroscopy ( 1 H NMR and 13 C NMR), and scanning electron microscopy (SEM), whereas their mechanical properties were evaluated by a universal testing machine. Additionally, their water uptake, swelling behavior, and degradation were evaluated to be used as drug delivery carriers. Therefore, an anti-cancer drug was loaded to these PUs with 25% of loading efficiency and its release behavior was studied using different theoretical models to unveil its mechanism. Finally, the ability of the new PUs to be used as a clip marker in breast biopsy was evaluated. The results clearly demonstrate that these PUs are safe and can be used as intelligent drug release matrices for targeted drug delivery and exhibits positive results to be used for clip marker and in general for breast cancer applications.

Inulin-Coated Iron Oxide Nanoparticles: A Theranostic Platform for Contrast-Enhanced MR Imaging of Acute Hepatic Failure

“…Then, the polymer degradation occurred at the temperature range of 180–277 °C (weight loss of 33.4%) which is related to the initial decomposition of the inulin glycosidic linkages and the last transition step of decomposition and combustion of inulin completed from 277 to 650 °C (weight loss of 30.7%). The results are in line with previously published reports. , …”

Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications

“…The production of polymeric elastomers required long hour of polymerization and high temperature to complete the curing process, while for the synthesis of polyurethane-foam like material, the polymerization reaction was relatively convenient, by reacting the polyols with diisocyanate at room temperature and the polyurethanes are formed within minutes of time. As discussed, the biodegradable and biocompatible polyurethanes were ventured into biomaterial applications such as scaffold for tissue engineering [ 26 ], carriers for anti-cancer drugs [ 27 ], and biomaterials for wound dressings [ 28 ] and soft tissue adhesive [ 12 ]. Scaffold is a temporary implant which provides framework for the regeneration of new tissues and subsequently degrades and eliminates from the body gradually as waste without causing negative impact to the body [ 29 ].…”

Electro-thermal properties and characterization of the flexible polyurethane-graphene nanocomposite films

“…According to general survey and literature [61,62], the first peak at 1725∼1730 cm −1 , a C=O vibration from ester groups and urethane from amide; 1440∼1445 cm −1 corresponds to a N=C=O asymmetric vibration (according to FTIR analyze NCO peak of PU/G samples are declined), and 1303 ∼ 1308 cm −1 was assigned to a urethane stretching or bending C-H vibration from amide III and 863-867 cm −1 corresponds to C-H wagging vibration of ester groups [63][64][65].…”