Inulin and Its Application in Drug Delivery

Afinjuomo, Franklin; Abdella, Sadikalmahdi; Youssef, Souha H.; Song, Yunmei; Garg, Sanjay

doi:10.3390/ph14090855

Cited by 40 publications

(33 citation statements)

References 231 publications

(326 reference statements)

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“…Inulin is a natural fructan polysaccharide that can be found in a variety of plants. This compound is made of fructose and glucose units in a flexible backbone, which gives it considerable versatility [ 139 ]. Inulin has been widely used in drug delivery systems because of its rapid water solubility, low friability, and stability via oral administration [ 140 ], as well as a successful ocular permeation enhancer [ 141 ].…”

Section: Resultsmentioning

confidence: 99%

The Use of Polymer Blends in the Treatment of Ocular Diseases

et al. 2022

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The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug delivery systems (DDS) have been widely explored since they show numerous advantages over conventional methods, besides delivering the content to the eye without interfering with its normal functioning. Polymers are usually used in DDS and many of them are applicable to ophthalmic use, especially biodegradable ones. Even so, it can be a hard task to find a singular polymer with all the desirable properties to deliver the best performance, and combining two or more polymers in a blend has proven to be more convenient, efficient, and cost-effective. This review was carried out to assess the use of polymer blends as DDS. The search conducted in the databases of Pubmed and Scopus for specific terms revealed that although the physical combination of polymers is largely applied, the term polymer blend still has low compliance.

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Section: Resultsmentioning

confidence: 99%

The Use of Polymer Blends in the Treatment of Ocular Diseases

et al. 2022

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“…Furthermore, in Table 3 , it is shown that the sizes of NQs and NBs were influenced by the medium in which the nanoparticles were suspended; in an aqueous medium, a slight relaxation of inulin was reported, with pores generated in the matrix and a swelling of the sphere, due to the relaxation of the polymeric chains. This normally occurs in nanoparticles with inulin form a hydrophilic layer [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Optimization of the Synthesis of Natural Polymeric Nanoparticles of Inulin Loaded with Quercetin: Characterization and Cytotoxicity Effect

et al. 2022

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Quercetin is a bioactive component that is capable of having therapeutic potential in the prevention of different noncommunicable chronic diseases (NCDs). However, it presents instability in the gastrointestinal tract in addition to low bioavailability. One way to overcome the limitations of quercetin lies in using nanotechnology for the development of nanoparticles, based on biopolymers, that are capable of being ingestible. Inulin, a fructan-type polysaccharide, acts as a delivery system for the release of quercetin in a target cell, guaranteeing the stability of the molecule. Inulin-coated quercetin nanoparticles were synthesized by the spray dryer method, and four variables were evaluated, namely inulin concentration (5–10% w/v), feed temperature (40–60 °C), inlet temperature (100–200 °C) and outlet temperature (60–100 °C). The optimal conditions were obtained at 10% w/v inulin concentration, with 45 °C feed temperature, 120 °C inlet temperature and 60 °C outlet temperature, and the nanoparticle size was 289.75 ± 16.3 nm in water. Fluorescence microscopy indicated quercetin loading in the inulin nanoparticles, with an encapsulation efficiency of approximately 73.33 ± 7.86%. Inulin-coated quercetin nanoparticles presented effects of inhibition in Caco-2 and HepG2 cells, but not in HDFa cells. The experimental data showed the potential of inulin nanoparticles as transport materials for unstable molecules, in oral administration systems, for the encapsulation, protection and release of quercetin.

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“…The 3D structure and water dispersed phase hydrogels can encapsulate water-soluble drugs, though water-insoluble drugs can also be loaded. Macromolecular compounds or bioactive molecules, such as genes, peptides, proteins or even living cells or organs can also be entrapped in hydrogels [ 14 , 54 , 55 , 56 ]. Figure 17 [ 57 ] and Figure 18 [ 58 ] illustrate drug delivery of IHs.…”

Section: Current Trendsmentioning

confidence: 99%

Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

et al. 2022

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Injectable hydrogels (IHs) are smart biomaterials and are the most widely investigated and versatile technologies, which can be either implanted or inserted into living bodies with minimal invasion. Their unique features, tunable structure and stimuli-responsive biodegradation properties make these IHs promising in many biomedical applications, including tissue engineering, regenerative medicines, implants, drug/protein/gene delivery, cancer treatment, aesthetic corrections and spinal fusions. In this review, we comprehensively analyze the current development of several important types of IHs, including all those that have received FDA approval, are under clinical trials or are available commercially on the market. We also analyze the structural chemistry, synthesis, bonding, chemical/physical crosslinking and responsive release in association with current prospective research. Finally, we also review IHs’ associated future prospects, hurdles, limitations and challenges in their development, fabrication, synthesis, in situ applications and regulatory affairs.

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Inulin and Its Application in Drug Delivery

Cited by 40 publications

References 231 publications

The Use of Polymer Blends in the Treatment of Ocular Diseases

The Use of Polymer Blends in the Treatment of Ocular Diseases

Optimization of the Synthesis of Natural Polymeric Nanoparticles of Inulin Loaded with Quercetin: Characterization and Cytotoxicity Effect

Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

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