Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

Almawash, Saud; Osman, Shaaban K.; Mustafa, Gulam; Hamd, Mohamed A. El

doi:10.3390/ph15030371

Cited by 53 publications

(50 citation statements)

References 90 publications

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“…Mechanism of gelation, rate kinetics, viscosity during the injection time, mechanical strength after gelation, the duration of deterioration, and the release profile of bioactive factors are critical for sensitive biological therapeutics . These injectable hydrogels, in order to be effective, targeted, and responsive to a broad range of medical diseases and pathogenesis, they require a set of design specifications linked to chemical-physical cross-linking and biological compatibility . One of the challenge for the injectable hydrogel system is to maintain the mechanical robustness while maintaining low viscosity and sustainability of enough elasticity in situ .…”

Section: Challenges With the State-of-art Research Of Injectable Hydr...mentioning

confidence: 99%

Emerging Role of Injectable Dipeptide Hydrogels in Biomedical Applications

et al. 2023

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Owing to their properties such as biocompatibility, tunable mechanical properties, permeability toward oxygen, nutrients, and the ability to hold a significant amount of water, hydrogels have wide applications in biomedical research. They have been engaged in drug delivery systems, 3D cell culture, imaging, and extracellular matrix (ECM) mimetics. Injectable hydrogels represent a major subset of hydrogels possessing advantages of site-specific conformation with minimal invasive techniques. It preserves the inherent properties of drug/biomolecules and is devoid of any side effects associated with surgery. Various polymeric materials utilized in developing injectable hydrogels are associated with the limitations of toxicity, immunogenicity, tedious manufacturing processes, and lack of easy synthetic tunability. Peptides are an important class of biomaterials that have interesting properties such as biocompatibility, stimuli responsiveness, shear thinning, self-healing, and biosignaling. They lack immunogenicity and toxicity. Therefore, numerous peptide-based injectable hydrogels have been explored in the past, and a few of them have reached the market. In recent years, minimalistic dipeptides have shown their ability to form stable hydrogels through cooperative noncovalent interactions. In addition to inherent properties of lengthy peptide-based injectable hydrogels, dipeptides have the unique advantages of low production cost, high synthetic accessibility, and higher stability. Given the instances of expanding significance of injectable peptide hydrogels in biomedical research and an emerging recent trend of dipeptide-based injectable hydrogels, a timely review on dipeptide-based injectable hydrogels shall highlight various aspects of this interesting class of biomaterials. This concise review that focuses on the dipeptide injectable hydrogel may stimulate the current trends of research on this class of biomaterial to translate its significance as interesting products for biomedical applications.

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Section: Challenges With the State-of-art Research Of Injectable Hydr...mentioning

confidence: 99%

Emerging Role of Injectable Dipeptide Hydrogels in Biomedical Applications

et al. 2023

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show abstract

“…The new approaches try to overcome some deficiencies of many hydrogels concerning mechanical robustness, slow or delayed response times to external stimuli, loading and release of therapeutic agents, etc.-or to include new properties and functionalitiesbiocompatibility, biodegradability, immunological compatibility, prolonged therapeutics, easy handling, and use, etc. [301,302]. Alternatives for overcoming the actual limitations are also given by the nature principle applied in orthogonal crosslinking or selfassembling methods, multi-component and hybrid networks, stimuli-responsive hydrogels and nanogels, 3D printed hydrogels, and electrospun nanofibers [30][31][32][33].…”

Section: Future Perspectivementioning

confidence: 99%

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Bercea¹

2022

Polymers

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Hydrogels, as interconnected networks (polymer mesh; physically, chemically, or dynamic crosslinked networks) incorporating a high amount of water, present structural characteristics similar to soft natural tissue. They enable the diffusion of different molecules (ions, drugs, and grow factors) and have the ability to take over the action of external factors. Their nature provides a wide variety of raw materials and inspiration for functional soft matter obtained by complex mechanisms and hierarchical self-assembly. Over the last decade, many studies focused on developing innovative and high-performance materials, with new or improved functions, by mimicking biological structures at different length scales. Hydrogels with natural or synthetic origin can be engineered as bulk materials, micro- or nanoparticles, patches, membranes, supramolecular pathways, bio-inks, etc. The specific features of hydrogels make them suitable for a wide variety of applications, including tissue engineering scaffolds (repair/regeneration), wound healing, drug delivery carriers, bio-inks, soft robotics, sensors, actuators, catalysis, food safety, and hygiene products. This review is focused on recent advances in the field of bioinspired hydrogels that can serve as platforms for life-science applications. A brief outlook on the actual trends and future directions is also presented.

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“…The focus switched to the creation of stereo-complexed biomaterials and hydrogels joined through physical interactions in the third-generation hydrogels. These changes prompted scientists to focus their efforts more intently on creating the current "smart hydrogels," which can be tailored to acquire specific qualities like stimulus responsiveness and adjustable mechanical and other physicochemical properties [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

“…Generally speaking, there are two types of hydrophilic polymers that are utilized to make hydrogels: natural polymers taken from tissues or other natural sources, and synthetic polymers created utilizing organic chemistry and molecular engineering concepts. Building blocks of synthetic and biocompatible natural polymers are used to create the injectable hydrogels shown in Table 1 [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

Injectable and Self-Invigorating Hydrogel Applications in Dentistry and Periodontal Regeneration: A Literature Review

Shirbhate¹,

Bajaj²

2022

Cureus

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Hydrogels are thought of as unique polymers utilized to build new materials, and two key factors that impact their features are their hydrophilicity and the degree of cross-linking of the polymer chains. An injectable hydrogel is based on the hypothesis that certain biomaterials can be injected into the body as a liquid and progressively solidify there. The scientific research community was intrigued and interested by its discovery. The hydrophilic polymers that are used to make hydrogels can typically be split into two groups: natural polymers derived from tissues or other sources of natural materials, and synthetic polymers produced by combining principles from organic chemistry and molecular engineering. A variety of organic and synthetic biomaterials, such as chitosan, collagen or gelatin, alginate, hyaluronic acid, heparin, chondroitin sulfate, polyethylene glycol, and polyvinyl alcohol, are used to generate injectable hydrogels. A promising biomaterial for the therapeutic injection of cells and bioactive chemicals for tissue regeneration in both dentistry and medicine, injectable hydrogels have recently attracted attention. Since injectable scaffolds can be implanted with less invasive surgery, their application is seen as a viable strategy in the regeneration of craniofacial tissue. Treatment for periodontitis that effectively promotes periodontal regeneration involves injecting a hydrogel that contains medications with simultaneous anti-inflammatory and tissueregenerating capabilities. The advantages of injectable hydrogel for tissue engineering are enhanced by the capability of three-dimensional encapsulation. A material's injectability can be attributed to a variety of mechanisms. The hydrogels work well to reduce inflammation and promote periodontal tissue regeneration.

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Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

Cited by 53 publications

References 90 publications

Emerging Role of Injectable Dipeptide Hydrogels in Biomedical Applications

Emerging Role of Injectable Dipeptide Hydrogels in Biomedical Applications

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

Injectable and Self-Invigorating Hydrogel Applications in Dentistry and Periodontal Regeneration: A Literature Review

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