Inulin: A novel and stretchy polysaccharide tool for biomedical and nutritional applications

Gupta, Nitin; Jangid, Ashok Kumar; Pooja, Deep; Kulhari, Hitesh

doi:10.1016/j.ijbiomac.2019.03.188

Cited by 92 publications

(49 citation statements)

References 81 publications

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“…Inulin is a complex polymeric carbohydrate (polysaccharide) that is natural and hydrophilic. It is an inexpensive dietary fiber compound that is a linear natural plant-derived polysaccharide and is linked by a fructose unit chain and linked by glycosidic bonds [71,72]. Recently, inulin has been characterized as a more potent adjuvant as it enhances humoral and cellular immune responses when administered with antigens [73].…”

Section: Inulinmentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

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Polymer-based nanoparticles have good solubility, stability, safety, and sustained release,which increases the absorption of loaded drugs, protects the drugs from degradation, and prolongs their circulation time and targeted delivery. Generally, we believe that prevention and control of infectious diseases through inoculation is the most efficient measure. However, these vaccines including live attenuated vaccines, inactivated vaccines, protein subunit vaccines, recombinant subunit vaccines, synthetic peptide vaccines and DNA vaccines have several defects, such as immune tolerance, poor immunogenicity, low expression level and induction of respiration pathological changes. All kinds of biodegradable natural and synthetic polymers play major roles in the vaccine delivery system to control the release of antigens for an extended period of time. In addition, these polymers also serve as adjuvants to enhance the immunogenicity of vaccine. This review mainly introduces natural and synthetic polymer-based nanoparticles and their formulation and properties. Moreover, polymer-based nanoparticles as adjuvants and delivery carriers in the applications of vaccine are also discussed. This review provides the basis for further operation of nano vaccines by utilizing the polymer-based nanoparticles as vaccine adjuvants and delivery systems. Polymer-based nanoparticles have exhibited great potential in improving the immunogenicity of antigens and the development of nano vaccines in future.

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Section: Inulinmentioning

confidence: 99%

Applications of polymer-based nanoparticles in vaccine field

Guo

Utupova

et al. 2019

Nanotechnology Reviews

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“…These properties are intrinsic to their roles in response to stress (Versluys et al, 2018) or developmental signals (Bolouri Moghaddam and Van den Ende, 2013). Fructans are exploited commercially as a replacement for sugar or fats, as fiber or prebiotics (Vijn and Smeekens, 1999) and have useful properties for drug delivery and cryoprotection (Audouy et al, 2011;Gupta et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The Sweet Taste of Adapting to the Desert: Fructan Metabolism in Agave Species

Pérez-López

Simpson

2020

Front. Plant Sci.

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Over 70% of Agave species, (159 of 206) are found in Mexico and are well adapted to survive under hot, arid conditions, often in marginal terrain, due to a unique combination of morphological and physiological attributes. In the pre-Columbian era agaves were also key to human adaptation to desert terrain. In contrast to other species such as cacti or resurrection plants, Agaves store carbohydrates in the form of fructan polymers rather than starch or sucrose, however, properties specific to fructans such as a strong hydration shell, the ability to be transported through phloem, variable composition throughout the Agave life-cycle and accumulation in succulent tissues and flowers suggest a potential for multiple functional roles. This mini-review summarizes current knowledge of molecular and biochemical aspects of fructan metabolism in Agave species.

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“…3 , Fig. 4 ) ( Gupta, Jangid, Pooja, & Kulhari, 2019 ; Sardo et al, 2015 ). Schiff base reactions represent a systematic mechanism to develop modified inulin derivatives, with several applications in photochromic materials, food preservatives, analytical chemistry, synthetic medicine, protein delivery, and tissue engineering as well as wound healing and self-healing ( Ansari & Bhat, 2019 ; Anush, Vishalakshi, Kalluraya, & Manju, 2018 ; Berhanu et al, 2019 ; Wang, Yuan, Li, Li, & Jiang, 2016 ).…”

Section: Chemistry and Synthesis Of Hmimentioning

confidence: 98%