Intussusceptive angiogenesis as a key therapeutic target for cancer therapy

Sekaran, Saravanan; Vimalraj, Selvaraj; Koka, Pavani; Nikarika, Ramesh; Sumantran, Venil N.

doi:10.1016/j.lfs.2020.117670

Cited by 53 publications

(28 citation statements)

References 113 publications

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“…This phenomenon is induced by HIF, which promotes oncogene activation, pro-angiogenic factor expression, and anti-angiogenic factor suppression. The most important pro-angiogenic factors are vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factors (FGF) [ 183 ]. However, IL-1β is also an important regulator of angiogenesis.…”

Section: Pro-and Anti-tumor Effects Of Il-1βmentioning

confidence: 99%

Interleukin-1β and Cancer

Rébé

Ghiringhelli

2020

Cancers

197

110

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Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells, fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a second signal is required to allow IL-1β maturation by inflammasome-activated caspase-1. IL-1β is then released and leads to transcription of target genes through its ligation with IL-1R1 on target cells. IL-1β expression and maturation are guided by gene polymorphisms and by the cellular context. In cancer, IL-1β has pleiotropic effects on immune cells, angiogenesis, cancer cell proliferation, migration, and metastasis. Moreover, anti-cancer treatments are able to promote IL-1β production by cancer or immune cells, with opposite effects on cancer progression. This raises the question of whether or not to use IL-1β inhibitors in cancer treatment.

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Section: Pro-and Anti-tumor Effects Of Il-1βmentioning

confidence: 99%

Interleukin-1β and Cancer

Rébé

Ghiringhelli

2020

Cancers

197

110

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“…The angiogenic marker expressions was examined by Western blot after 24 h of MG63 cell xenografting in zebrafish embryos (Figure 6B). VEGFA, a-SMA, and Tie2 are all known to have a role in tumor angiogenesis and are employed as angiogenic markers (29,30). The expression of VEGFA, a-SMA, and Tie2 proteins was lower in embryos implanted with si-MALAT1transfected MG63 cells than in embryos implanted with sicontrol-transfected MG63 cells.…”

Section: Lncrna Malat1 Regulates Vegfa-mediated Tumor Angiogenesis In Os By Targeting Mir-150-5pmentioning

confidence: 99%

LncRNA MALAT1 Promotes Tumor Angiogenesis by Regulating MicroRNA-150-5p/VEGFA Signaling in Osteosarcoma: In-Vitro and In-Vivo Analyses

2021

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The present study aims to analyze the expression of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in human osteosarcoma (OS) cells and to investigate its role in OS-induced angiogenesis. MALAT1 expression in OS cells was significantly higher than in normal osteoblasts. The functional analysis indicated that MALAT1 appears to enhance OS-induced angiogenesis, in vitro and in vivo analyses, endothelial cell proliferation and migration, chick embryo angiogenesis assay, and zebrafish xenograft model. Mechanistically, silencing MALAT1 downregulated vascular endothelial growth factor A (VEGFA) expression and upregulated miR-150-5p expression in OS cells, and MALAT1-mediated angiogenic induction by VEGFA in OS microenvironment. Moreover, MALAT1 directly targeted miR-150-5p and miR-150-5p directly target VEGFA in OS. Overexpression of miR-150-5p downregulates VEGFA expression in OS. More notably, we showed that MALAT1 induced angiogenesis in OS microenvironment by upregulating the expression of VEGFA via targeting miR-150-5p. Overall, our findings suggest that MALAT1 promotes angiogenesis by regulating the miR-150-5p/VEGFA signaling in OS microenvironment. The findings of the molecular mechanisms of MALAT1 in tumor angiogenesis offer a new viewpoint on OS treatment.

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“…Although BAI1 is known as an anti-angiogenic factor, the detailed mechanisms of its anti-tumor and anti-angiogenic activity have yet to be elucidated. More importantly, in clinical trials, most conventional anti-angiogenic drugs target the sprouting angiogenesis, and unfortunately these drugs have become resistant and have minimal clinical benefits [ 40 ]. Therefore, it would be interesting to study the mechanism of action of BAI1 depending on the type of angiogenesis, such as sprouting angiogenesis and intussusceptive angiogenesis.…”

Section: Functions Of Bai1mentioning

confidence: 99%

Therapeutic Application of Brain-Specific Angiogenesis Inhibitor 1 for Cancer Therapy

Nair

Bolyard

Lee

et al. 2021

Cancers

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Brain-specific angiogenesis inhibitor 1 (BAI1/ADGRB1) is an adhesion G protein-coupled receptor that has been found to play key roles in phagocytosis, inflammation, synaptogenesis, the inhibition of angiogenesis, and myoblast fusion. As the name suggests, it is primarily expressed in the brain, with a high expression in the normal adult and developing brain. Additionally, its expression is reduced in brain cancers, such as glioblastoma (GBM) and peripheral cancers, suggesting that BAI1 is a tumor suppressor gene. Several investigators have demonstrated that the restoration of BAI1 expression in cancer cells results in reduced tumor growth and angiogenesis. Its expression has also been shown to be inversely correlated with tumor progression, neovascularization, and peri-tumoral brain edema. One method of restoring BAI1 expression is by using oncolytic virus (OV) therapy, a strategy which has been tested in various tumor models. Oncolytic herpes simplex viruses engineered to express the secreted fragment of BAI1, called Vasculostatin (Vstat120), have shown potent anti-tumor and anti-angiogenic effects in multiple tumor models. Combining Vstat120-expressing oHSVs with other chemotherapeutic agents has also shown to increase the overall anti-tumor efficacy in both in vitro and in vivo models. In the current review, we describe the structure and function of BAI1 and summarize its application in the context of cancer treatment.

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Intussusceptive angiogenesis as a key therapeutic target for cancer therapy

Cited by 53 publications

References 113 publications

Interleukin-1β and Cancer

Interleukin-1β and Cancer

LncRNA MALAT1 Promotes Tumor Angiogenesis by Regulating MicroRNA-150-5p/VEGFA Signaling in Osteosarcoma: In-Vitro and In-Vivo Analyses

Therapeutic Application of Brain-Specific Angiogenesis Inhibitor 1 for Cancer Therapy

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