Introduction—The Biology and Pathology of Squamous Cell Carcinomata in the Head and Neck

Johnson, Newell W.

doi:10.1007/978-94-024-1084-6_1

Cited by 4 publications

(5 citation statements)

References 79 publications

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“…The criteria used for inclusion into the study included the following: Adequate clinicopathologic data; histologically proven cases of oral epithelial dysplasia (moderate),[ 29 ] SCC (tumors were classified as well, moderately and poorly differentiated according to the WHO classification of histologic differentiation grade);[ 30 ] and no prior oncologic therapy.…”

Section: Methodsmentioning

confidence: 99%

Sonic hedgehog in oral squamous cell carcinoma: An immunohistochemical study

Srinath

Iyengar²,

Mysorekar

2016

J Oral Maxillofac Pathol

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Background:Recent studies have revealed the involvement of hedgehog (Hh) signaling component in proliferation and invasive behavior of many carcinomas.Aim:This study aims to identify the expression of sonic Hh (SHH) protein of SHH pathway in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) using SHH (H-160) (Santa Cruz, sc-9042) which could have therapeutic implication in future.Materials and Methods:A total of 250 cases comprising 50 normal oral mucosa, 50 cases of oral epithelial dysplasia, 50 well, 50 moderate and 50 poorly differentiated OSCCs were included in the study. Immunohistochemical evaluation of SHH protein expression was conducted using monoclonal antibody. Interpretation of the expression was done by immunoreactive score of Remmele and Stegner (IRS) scoring method.Statistical Analysis:Chi-Square test was used to analyze the results.Results:The study showed that SHH signaling molecules are highly expressed in OSCC, and their expression was mainly in the cytoplasm of epithelial cells.Conclusion:The SHH signaling component is associated with the pathological parameter in OSCC and oral epithelial dysplasia.

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Section: Methodsmentioning

confidence: 99%

Sonic hedgehog in oral squamous cell carcinoma: An immunohistochemical study

Srinath

Iyengar²,

Mysorekar

2016

J Oral Maxillofac Pathol

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“…The expert opinion at the 2005 workshop (published in 2007) proposed a shift from previously used terms "precancer", "epithelial precursor lesions", "premalignant", "precancerous", and "intra-epithelial lesion" to OPMD. Lesions and conditions were combined into one category of "disorders", in recognition of the fact that field change usually exists due to exposure to environmental carcinogens across much of the upper aero-digestive tract and that the whole person may have changes which influence the risk of cancer development (Johnson, 2017(Johnson, , 2020. "Potentially malignant" implies that not all patients diagnosed with any of these mucosal abnormalities will develop an oral malignancy.…”

Section: Introductionmentioning

confidence: 99%

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer

et al. 2020

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Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a workshop held by the World Health Organization (WHO) Collaborating Centre for Oral Cancer in the UK. The first workshop held in London in 2005 considered a wide spectrum of disorders under the term "potentially malignant disorders of the oral mucosa" (PMD) (now referred to as oral potentially malignant disorders: OPMD) including leukoplakia, erythroplakia, proliferative verrucous leukoplakia, oral lichen planus, oral submucous fibrosis, palatal lesions in reverse smokers, lupus erythematosus, epidermolysis bullosa, and dyskeratosis congenita. Any new evidence published in the intervening Medical Sciences,

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“…This new category was born because it was documented that the oral tissue affected by these conditions later evolved into OSCC. Additionally, the red and white tissue alterations that characterize these conditions can be present simultaneously in the border of the frank OSCC tissue [38][39][40]. The term "potentially malignant" underlines that not always the altered oral mucosa affected by these conditions will necessarily evolve in oral carcinoma.…”

Section: Oral Squamous Carcinoma and Oral Potentially Malignant Disor...mentioning

confidence: 99%

Chemopreventive and Biological Strategies in the Management of Oral Potentially Malignant and Malignant Disorders

Viglianisi,

Polizzi,

Grippaudo

et al. 2024

Bioengineering

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Oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) represent a significant global health burden due to their potential for malignant transformation and the challenges associated with their diagnosis and treatment. Chemoprevention, an innovative approach aimed at halting or reversing the neoplastic process before full malignancy, has emerged as a promising avenue for mitigating the impact of OPMD and OSCC. The pivotal role of chemopreventive strategies is underscored by the need for effective interventions that go beyond traditional therapies. In this regard, chemopreventive agents offer a unique opportunity to intercept disease progression by targeting the molecular pathways implicated in carcinogenesis. Natural compounds, such as curcumin, green tea polyphenols, and resveratrol, exhibit anti-inflammatory, antioxidant, and anti-cancer properties that could make them potential candidates for curtailing the transformation of OPMD to OSCC. Moreover, targeted therapies directed at specific molecular alterations hold promise in disrupting the signaling cascades driving OSCC growth. Immunomodulatory agents, like immune checkpoint inhibitors, are gaining attention for their potential to harness the body’s immune response against early malignancies, thus impeding OSCC advancement. Additionally, nutritional interventions and topical formulations of chemopreventive agents offer localized strategies for preventing carcinogenesis in the oral cavity. The challenge lies in optimizing these strategies for efficacy, safety, and patient compliance. This review presents an up to date on the dynamic interplay between molecular insights, clinical interventions, and the broader goal of reducing the burden of oral malignancies. As research progresses, the synergy between early diagnosis, non-invasive biomarker identification, and chemopreventive therapy is poised to reshape the landscape of OPMD and OSCC management, offering a glimpse of a future where these diseases are no longer insurmountable challenges but rather preventable and manageable conditions.

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Introduction—The Biology and Pathology of Squamous Cell Carcinomata in the Head and Neck

Cited by 4 publications

References 79 publications

Sonic hedgehog in oral squamous cell carcinoma: An immunohistochemical study

Sonic hedgehog in oral squamous cell carcinoma: An immunohistochemical study

Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer

Chemopreventive and Biological Strategies in the Management of Oral Potentially Malignant and Malignant Disorders

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