Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer

Warnakulasuriya, Saman; Kujan, Omar; Aguirre‐Urízar, José Manuel; Bagán, José; González‐Moles, Miguel Ángel; Kerr, Alexander Ross; Lodi, Giovanni; Mello, Fernanda Weber; Monteiro, Luís Silva; Ogden, Graham S.; Sloan, Philip; Johnson, Newell W.

doi:10.1111/odi.13704

Cited by 549 publications

(685 citation statements)

References 139 publications

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“…Though PVL is a well recognized oral potentially malignant disorder 30 follow‐up studies reporting on malignant transformation have been limited 21 . Retrospective studies reported so far have inherent limitations and multi‐centre prospective studies are needed to explore the natural history of this disorder.…”

Section: Discussionmentioning

confidence: 99%

Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia

McParland

Warnakulasuriya

2021

J Oral Pathology Medicine

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Background Recognition and differentiation of early forms of proliferative verrucous leukoplakia (PVL) could be a challenge to both clinicians and pathologists. Objective To report on a retrospective study that was carried out on 51 cases of PVL that were initially diagnosed as frictional keratosis, oral leukoplakia or oral lichen planus. A secondary objective is to report on the outcome of malignant transformation during follow‐up. Methods Records of patients seen at an oral medicine clinic with the final clinical diagnosis of PVL were audited for early clinical and histopathologic features in their biopsy at first presentation, and for subsequent malignant transformation. Results Fifty‐one patients (25 men and 26 women) with a mean age 51 years (men) and 53 years (women) at initial presentation were studied. 28% men and 11.5% women were current smokers. Initial clinical diagnoses were frictional keratoses (n = 4), Leukoplakia (n = 17) and lichen planus (n = 30). Epithelial dysplasia was reported in the initial biopsy in 12 cases and lichen planus/lichenoid features in 22 cases (22/51; 43%). Malignant transformation occurred in 11/51 patients (21.5%). Conclusion Lichen planus or lichenoid lesions could be the initial presentation of many PVL cases that later develop multiple leukoplakic lesions with a final diagnosis of PVL.

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Section: Discussionmentioning

confidence: 99%

Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia

McParland

Warnakulasuriya

2021

J Oral Pathology Medicine

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“…A recent review of classification and nomenclature of oral potentially malignant disorders (OPMD) was published by invited experts of the WHO Collaborating Centre for Oral Cancer 1 . OPMDs are a group of mucosal disorders that may precede the diagnosis of oral squamous cell carcinoma (OSCC) 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Although many researchers across the globe adopted this term, many discrepancies in describing these disorders are still found leading to inconsistency and confusion. The nomenclature and classification for disorders that precede the development of cancers evolved over the years to align and reflect advances in the understanding of the natural history of these disorders 1 …”

Section: Introductionmentioning

confidence: 99%

“…The consensus paper of WHO Collaborating Centre 2020 defined PVL as a progressive, persistent and irreversible disorder characterized by the presence of multiple leukoplakias that frequently become warty . Despite the imperfection of the term PVL to capture an expanded group of multifocal conditions, the term is widely reported and this expert group recommended retaining this term 1 . PVL was first described by Hansen et al 5 in 1985.…”

Section: Introductionmentioning

confidence: 99%

“…The lichenoid clinical appearance of the early stages of PVL could lead clinicians to treat erroneously OLP for many years, with the risk of missing or accelerating subsequent malignancy 1 . Clinical (white and red components) and histological features of OLP or OLL are found at the initial stages of PVL, leading to the diagnosis of Lichenoid‐PVL 7 .…”

Section: Introductionmentioning

confidence: 99%

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Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis

Gilligan

Garola

Piemonte

et al. 2020

J Oral Pathology Medicine

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Background Multiple white plaques of the oral mucosa are usually associated with potentially malignant disorders such as oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia. Previous studies in the current literature describe a potential clinical overlap in these entities. The aim of this study is to review clinicopathological and evolutive features of these Oral Potentially Malignant Disorders highlighting the dynamic changes of diagnoses. Discussion It was previously hypothesized that a subset of patients with oral lichen planus or oral lichenoid diagnosis, could develop multiple white plaques during the natural history of the disease, fulfilling diagnostic criteria for proliferative verrucous leukoplakia. Consequently, these entities could, under certain conditions, obey a continuum of the same precancerous condition in the context of the field cancerization theory, increasing the risk of malignant transformation. Nevertheless, there is limited scientific evidence concerning this issue. Conclusion Further studies are needed to understand the biological and evolutive features of the link between these oral potentially malignant disorders. Regardless of its diagnosis, these patients with multifocal white lesions must be carefully monitored to detect early malignant transformation.

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Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults

Walsh

Warnakulasuriya

Lingen

et al. 2021

Cochrane Database of Systematic Reviews

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BackgroundThe early detection of oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD), followed by appropriate treatment, may improve survival and reduce the risk for malignant transformation respectively. This is an update of a Cochrane Review first published in 2013. ObjectivesTo estimate the diagnostic test accuracy of conventional oral examination, vital rinsing, light-based detection, mouth self-examination, remote screening, and biomarkers, used singly or in combination, for the early detection of OPMD or OSCC in apparently healthy adults.

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Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer

Cited by 549 publications

References 139 publications

Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia

Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia

Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis

Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults

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