Indian dental patients were in favour of chairside medical screening.

Background:Recent studies have revealed the involvement of hedgehog (Hh) signaling component in proliferation and invasive behavior of many carcinomas.Aim:This study aims to identify the expression of sonic Hh (SHH) protein of SHH pathway in oral epithelial dysplasia and oral squamous cell carcinoma (OSCC) using SHH (H-160) (Santa Cruz, sc-9042) which could have therapeutic implication in future.Materials and Methods:A total of 250 cases comprising 50 normal oral mucosa, 50 cases of oral epithelial dysplasia, 50 well, 50 moderate and 50 poorly differentiated OSCCs were included in the study. Immunohistochemical evaluation of SHH protein expression was conducted using monoclonal antibody. Interpretation of the expression was done by immunoreactive score of Remmele and Stegner (IRS) scoring method.Statistical Analysis:Chi-Square test was used to analyze the results.Results:The study showed that SHH signaling molecules are highly expressed in OSCC, and their expression was mainly in the cytoplasm of epithelial cells.Conclusion:The SHH signaling component is associated with the pathological parameter in OSCC and oral epithelial dysplasia.

Objectives: Assessment of the cell proliferation rate in tissues can be one of the markers for impending malignancy in precancers. The state of activation and the proliferation activity of the cells can be assessed by the frequency of silver stained Nucleolar Organiser regions (AgNOR) within the nuclei which is significantly higher in malignant cells. The present study was carried out to analyze the distribution of the AgNOR in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC), and in their various histological grades, and to assess if the AgNOR distribution could give information on the malignant potentiality in premalignant lesions and aggressiveness of the malignant lesions. Study design: The study specimens comprised of 35 archival cases, of which 15 cases were of OL and 20 cases of OSCC. The specimens were stained by hematoxylin and eosin and modified silver staining method of Ploton et al. for the Nucleolar Organiser Regions. The specimens were analyzed independently by the two observers and was further statistically analysed. Results: The mean AgNOR count in OL was 2.80 ±0.50 and in cases of OSCC was 5.71± 1.08. The mean AgNOR count in OL cases of mild dysplasia was 2.59 ±0.66, in moderate dysplasia was 2.92± 0.43 and in severe dysplasia was 2.79. The mean AgNOR count in cases of well differentiated OSCC was 5.73± 1.62 and in cases of moderately differentiated OSCC was 5.67±1.19. Conclusion: The mean AgNOR count was higher in cases of OSCC as compared to cases of OL, and the AgNOR counts increased with the increase in the grades of dysplasia indicating a higher proliferative rate with increase in dysplasia.

Background: Temporomandibular joint disorders (TMDs) are one of the major causes of chronic orofacial pain affecting 28-86% of the population. The diagnosis of TMDs is challenging to a considerable number of practitioners and is influenced by their knowledge, attitude and experience. Aim: This study aimed at assessing the knowledge, attitude and practices regarding TMDs among TMD experts and general dental practitioners (GDPs) in India. Materials and Methods: A total of 200 dental practitioners (32 TMD experts and 168 GDPs) across India, registered under the Dental Council of India, were included in the survey. A questionnaire consisting of 21 issues with regard to TMDs was designed from relevant standard textbooks. The questionnaire was pretested for validation and distributed personally or through the web designed program. The knowledge and attitude scores of both the groups were assessed and compared. The therapeutic modalities practiced by the groups were also noted. Results: A significant difference was found in the knowledge scores and attitude between TMD experts and GDPs. A significant correlation was found between attitude score and years of experience in both the groups. Both TMD experts and GDPs expressed little confidence in the management of TMDs. About 75% of GDPs expressed concern over an inadequate number of TMD experts. Conclusion: Need for continued updating of knowledge, panel discussions, and revisions of the curriculum in graduate schools was realized.

Context:Tobacco abuse is a well-known risk factor for potentially malignant disorders as well as oral squamous cell carcinoma (SCC). Factors that influence tobacco-exposed individuals developing a malignancy may include a combination of total tobacco exposure and genetic susceptibility.Aim:This study was undertaken to determine the prevalence of the glutathione S-transferase M1 (GSTM1) null polymorphism in oral leukoplakia and oral SCC patients in South Indian population.Settings and Design:This case-control study was conducted in hospital setting on South Indian population.Materials and Methods:Totally, 280 subjects with a history of tobacco use, oral leukoplakia, oral SCC were included in this study. Three milliliter of blood was collected and transported under cold cycle and taken for evaluation of GSTM1 null polymorphism using Multiplex Polymerase Chain Reaction.Results and Discussion:On comparing the prevalence of GSTM1 null polymorphism among the group with subjects with habits and no oral lesions, oral leukoplakia and oral SCC, it was observed that there was a statistically significant association between GSTM1 null polymorphism and the different groups (P < 0.01).Conclusion:The lack of GSTM1 activity would make the oral tissues more susceptible to action of tobacco carcinogens and to the development of a high-grade level of dysplasia in oral leukoplakia and thereby increases the susceptibility of lesion to undergo malignant changes.

Louis Edouard Octave Crouzon, a French neurologist, in 1912, described the hereditary syndrome of craniofacial synostosis in a mother and son. He described the triad as skull deformities, facial anamolies and exopthalmos now known as Crouzon syndrome (CS). CS accounts for about 4.8% of all cases of craniosynostosis. We report a case of CS in 4 year old girl with characteristic features of cranial deformity, maxillary hypoplasia, cleft palate and exopthalmos.

Background. Temporomandibular disorders (TMDs) are among the common musculoskeletal conditions affecting the individual. Anxiety plays an important role in the pathogenesis of TMD. Modern lifestyle and work environment bring to focus the role of anxiety in everyday life which is changing the demographics of diseases like TMD. This study compared the anxiety scores between TMD patients and normal subjects. Material and Methods. 505 individuals were included in the study who were divided into group 1 with 255 individuals presenting with signs and symptoms of TMD and group 2 with 250 normal individuals as controls. Hospital anxiety depression scale was used to calculate the anxiety scores. Fischer's t test was used to compare the anxiety scores between the two groups. Results. 80% of individuals in group 2 and 44% in group 1 individuals had normal anxiety scores. 45% of the individuals in group 1 and 19% in group 2 had borderline anxiety scores. 11% of group 1 individuals and <1% of group 2 individuals demonstrated high anxiety scores. These results were statistically significant. Conclusion. Individuals with TMD exhibited higher levels of anxiety scores whereas significant number of control subjects exhibited normal anxiety scores.

Objective. The prevalence of bronchial asthma is increasing globally by 50% every decade. With more individuals presenting with a medical history of asthma and concurrent medication usage, its impact on oral cavity needs to be recognized. The present study was conducted with an aim to assess the oral health status of individuals with asthma aged 12 years and older and to evaluate the effect of various antiasthma medications on oral health. Materials and Methods. Forty individuals with asthma (22 females and 18 males) between 12 and 66 years of age were included in the study after following extensive exclusion criteria. For all subjects a detailed case history was taken. A thorough oral examination was conducted to determine caries experience, periodontal status, and candidiasis. Furthermore, whole unstimulated saliva was collected for pH estimation and cytological smears obtained for the screening of candidiasis. Results. Of the 40 subjects examined, a history of xerostomia was found in 55%, stomatopyrosis in 22%, and halitosis in 5%. The mean DMFT (decayed, missing, filled teeth) was 4.97. Periodontal treatment need evaluation revealed the requirement for oral hygiene education and professional prophylaxis in most of the subjects. However, no significant correlation was found between use of antiasthma medications and periodontal needs. An acidic pH was found in 52.5% of the subjects and candidiasis was detected in 65%. Conclusion. A high incidence of xerostomia, acidic pH, and candidiasis was found in those having asthma. Studies with a larger sample size may help confirm these findings. However, it is suggested that asthma patients on regular antiasthma treatment need special attention in the area of oral health care.