Introduction of Poly(4-Vinylpyridine) as an Efficient Promotor for the Synthesis of Pyrano[2,3-d]Pyrimidinones and Pyrido[2,3-d]Pyrimidines

Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

“…Also, a green method has been developed for the synthesis of bicyclic pyranopyrimidinones through three-component one-pot reactions of malononitrile with aryl aldehydes, and barbituric acid under catalytic conditions using poly(4-vinylpyridine) in water at reflux conditions. 50 …”

“…Also, a green method has been developed for the synthesis of bicyclic pyranopyrimidinones through three-component one-pot reactions of malononitrile with aryl aldehydes, and barbituric acid under catalytic conditions using poly(4-vinylpyridine) in water at reux conditions. 50 Zaharani et al 51 have developed the synthesis of bicyclic systems with enaminonitrile moiety by the utility of TMDP as an efficient N-heterocycle organocatalyst. The approach in this type Scheme 3 Synthesis of tetrahydro-2H-pyranopyrimidines.…”

A novel magnetically recyclable semi‐dendrimer catalyst‐based ethanolpyridole supported on ferrite nanoparticles (HNPs@Py) for the synthesis of biscoumarin and dihydropyrano[3,2‐c]chromene derivatives

“…Also, a probable mechanism for the synthesis of biscoumarin is defined in Scheme 11. [16,23] Initially, the HNPs@Py catalyst activates the CH acidic group of malononitrile for the nucleophilic attack to the carbonyl group of aldehyde to give compound (A). Then, elimination of water happens to provide compound (B).…”

“…[16][17][18][19][20][21] Therefore, designing efficient protocols for synthesis of biscoumarin and 3,4-dihydropyrano[c]chromene is an important and ideal goal in the green chemistry yet. [22] Although there are many reports for the synthesis of biscoumarin and 3,4-dihydropyrano[c]chromene in the presence of different catalysts such as poly(4vinylpyridine) (P4 VPy), [23] Fe 3 O 4 @SiO 2 -imid-PMA, [24] artificial sweetener saccharine-based ionic liquid, [25] magnetic nanostructured natural hydroxyapatite (HAP/Fe 3 O 4 NPs), [20] silica-supported Preyssler nanoparticles (HPA), [26] these methodologies have some notable defects such as long reaction times, hard reaction conditionism, using toxic catalysts, and low yields. So we wish to report an efficient and green synthesis of biscoumarin and 3,4-dihydropyrano[c]chromene derivatives using the novel organic-inorganic nanohybrid magnetic nanoparticles (HNPs@Py) that has removed all above defects.…”

Chitosan‐ZnO: An Efficient and Recyclable Polymer Incorporated Hybrid Nanocatalyst to Synthesize Tetrahydrobenzo[b]pyrans and Pyrano[2,3‐d]pyrimidinones under Microwave Expedition

“…Over the last decade, biopolymers, renewable and biodegradable organic polymers, polysaccharide-supported catalysts, along with or without the modification of the support such as starch, guar-gum, lignin, cellulose and hemicelluloses, carrageenans and chitosan have acquired enriched attention. [1] Literature survey revealed that homogeneous catalytic reactions have been analyzed to establish methodologies in which the use of metal nanoparticles supported onto polymers owing to their specificity towards attracting the metal nanoparticles. [2,3] Accumulation of nanoparticles over the surface of biopolymers is a leading area of research due to their potential applications in electronic devices, sensing, catalysis and bio-medicalsciences.…”