Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-<i>d</i>]pyrimidine core

El-Khateeb, A. Y.; Hamed, Sherifa S.; Elattar, Khaled M.

doi:10.1039/d2ra00927g

Cited by 23 publications

(21 citation statements)

References 145 publications

(219 reference statements)

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“…This review aims to highlight an example of polycyclic compounds containing the pyrimidine and pyridine cores of distinct biological significance. Through our previous research on the study of the importance of reactive synthons in the preparation of many heterocycles [ 24 , 25 ] and many reviews that discussed the chemistry of related fused pyrimidine [ 26 – 33 ] and pyridopyrimidine compounds [ 34 – 36 ], we discuss here the recent advancements on the chemistry of pyridodipyrimidine compounds. The subject of the research is concerned with studying the biological impacts and the distinct preparation approaches for this class of compounds in recent years.…”

Section: Introductionmentioning

confidence: 99%

Developments of pyridodipyrimidine heterocycles and their biological activities

et al. 2023

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The entitled review aimed to assemble and highlight the synthetic approaches and biological aspects of heterocycles with pyridodipyrimidine motifs. The recent synthetic approaches were categorized according to the accomplishments of the approaches under catalyst or catalyst-free conditions. The topic involved the synthesis of substituted tricyclic systems and spirocyclic systems. The present study offered an overview of the recent literature in addition to a scope of the preceding literature. The proposed mechanisms of the varied target products were discussed. Pyridodipyrimidine displayed potential and privileged cytotoxic, antioxidant, and antimicrobial performances. The competitions, challenges, and prospects are also deliberated.

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Section: Introductionmentioning

confidence: 99%

Developments of pyridodipyrimidine heterocycles and their biological activities

et al. 2023

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“…“ Green chemistry is an area of chemistry focused on the designing of products and processes that minimizes or eliminates the use and generation of hazardous substances (USEPA, 2006) ”. 7 The possible isomers 8 of pyranopyrimidines are shown in Figure 1 .…”

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confidence: 99%

“…Gore and Rajput 21 reported on the pyrimidine core synthesis, and Bhat et al 22 also reported on bioactive annulated pyrimidine derivatives. Recently, Elattar et al 23 reported on the pyrano[2,3- d ]pyrimidine core. These reported review articles lack many synthetic approaches for pyrano[2,3- d ]pyrimidine.…”

Section: Introductionmentioning

confidence: 99%

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

2023

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The pyranopyrimidine core is a key precursor for medicinal and pharmaceutical industries due to its broader synthetic applications as well as its bioavailability. Among its four possible isomers, we found that 5H-pyrano[2,3-d]pyrimidine scaffolds have a wide range of applicability, and in recent years, they have been intensively investigated, but the development of the main core is found to be more challenging due to its structural existence. In this review article, we cover all of the synthetic pathways that are employed for the development of substituted 4-aryl-octahydropyrano/hexahydrofuro[2,3-d]pyrimidin-2-one (thiones) and 5-aryl-substituted pyrano[2,3-d]pyrimidindione (2-thiones) derivatives through a one-pot multicomponent reaction using diversified hybrid catalysts such as organocatalysts, metal catalysts, ionic liquid catalysts, nanocatalysts, green solvents, catalyst-/solvent-free conditions, and miscellaneous catalysts as well as the mechanism and recyclability of the catalysts. This review mainly focuses on the application of hybrid catalysts (from 1992 to 2022) for the synthesis of 5H-pyrano[2,3-d]pyrimidine scaffolds. This review will definitely attract the world’s leading researchers to utilize broader catalytic applications for the development of lead molecules.

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“…The topic of this research is an extension of our previous study that is interesting to highlight the recent methods and progress in the multicomponent synthesis of heterocycle-incorporated pyrano[2,3- d ]pyrimidine motif under different conditions. 60…”

Section: Introductionmentioning

confidence: 99%

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs

2022

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Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

Abstract: The present review highlighted the recent developments of the multicomponent synthesis of heterocyclic compounds with pyrano[2,3-d]pyrimidine skeleton applying the diverse strategies.

Cited by 23 publications

References 145 publications

Developments of pyridodipyrimidine heterocycles and their biological activities

Developments of pyridodipyrimidine heterocycles and their biological activities

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs

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