“…In turn, the decreased viscosity was thought to help mobilize secretions and clear the airway (Özden et al, 2009;Morrow et al, 2004;Owen et al, 2016). However, current evidence shows that NS instillation can have potentially harmful effects, such as cardiac dysrhythmias (Gardner et al, 2009;Celik & Kanan, 2006;AARC Clinical Practice Guidelines, 2010), hypoxemia and desaturation (Gardner et al, 2009;Celik & Kanan, 2006;AARC Clinical Practice Guidelines, 2010;Leddy et al, 2015;Reeve et al, 2007;Akgül et al, 2002), atelectasis (AARC Clinical Practice Guidelines, 2010; Leddy et al, 2015;Ayhan, 2015), bronchospasm (Gardner et al, 2009), worsening dyspnea (Reeve et al, 2007;O'Neal et al, 2001), tachycardia infection (Gardner et al, 2009;Celik & Kanan, 2006;AARC Clinical Practice Guidelines, 2010), trauma to mucosal linings and airway cilia (Gardner et al, 2009), hypertension (Celik & Kanan, 2006;Akgül et al, 2002), increased intracranial pressure (Gardner et al, 2009;Celik & Kanan, 2006;Akgül et al, 2002) and anxiety and discomfort (Reeve et al, 2007;Ayhan et al, 2015;Blackwood, 1999;Halm et al, 2008;Ireton, 2008).…”