Intrinsic Dual-Emitting Carbon Quantum-Dot-Based Selective Ratiometric Fluorescent Mercaptopurine Detection

Abstract

, an immunosuppressive drug, has been widely prescribed for treating leukemia and autoimmune diseases. The level of the 6-MP drug in body fluids is of great interest due to the severe health problems related to its overdose. This study used a facile microwave preparation route to synthesize carbon quantum dots (CQDs) using glutathione and formamide as carbon sources. The obtained monodispersed quantum dots showed dual fluorescence emission with a sensitive affinity toward the 6-MP drug. The sensor's response was optimized by tuning the temperature, pH, and volume ratio of the probe. The prepared ratiometric fluorescence method showed accurate measurements for determining mercaptopurine in aqueous solutions in the concentration range of 1.4−7.6 mg L −1 with the limit of detection of 1.3 mg L −1 . The sensor's performance was assessed in complex solutions, human urine, and human plasma sample and recovery values in the range of 88− 127% were obtained. The reliable dual fluorometric sensor showed promising results for 6-MP determination and potential application for the determination of other chemical and biochemical species.

MOF-Fabric Composites Based on a Multi-Functional MOF as Luminescent Sensors for a Neurotransmitter and an Anti-Cancer Drug

“…According to earlier research, the absorption maxima of adrenaline and 6-MP are centered at 346 and 325 nm, respectively, which are within the excitation/ emission spectrum of 1′. 24,25 Consequently, there is a possibility of energy transfer between the MOF and the targeted analytes, which can enhance or quench the emission maxima of the probe. Indeed, the quenching in photo-luminescence of the MOF was observed after the addition of adrenaline and 6-MP solutions to the MOF suspension.…”