Intravenous magnesium for acute myocardial infarction

Comment to “Recommendation on an updated standardization of serum magnesium reference ranges”

“…Although cohort studies can be indicative of a positive effect of magnesium on human health, randomized controlled clinical (interventional) trials are required to prove first and foremost causality, and whether correcting serum magnesium towards a specific target value is therapeutic or preventive. A systematic review and meta-analysis of the effect of intravenous magnesium supplementation on myocardial infarction demonstrates that magnesium is not beneficial [14]. Similar outcomes were shown for stroke, as intravenous Mg 2+ supplementation did not improve mortality in patients with stroke [15].…”

Comment to “Recommendation on an updated standardization of serum magnesium reference ranges”

“…Although cohort studies can be indicative of a positive effect of magnesium on human health, randomized controlled clinical (interventional) trials are required to prove first and foremost causality, and whether correcting serum magnesium towards a specific target value is therapeutic or preventive. A systematic review and meta-analysis of the effect of intravenous magnesium supplementation on myocardial infarction demonstrates that magnesium is not beneficial [14]. Similar outcomes were shown for stroke, as intravenous Mg 2+ supplementation did not improve mortality in patients with stroke [15].…”

Magnesium in Man: Implications for Health and Disease

“…However, also a second large-scale randomized double-blind study with 6,213 patients and an earlier time point of Mg 2ϩ infusion (3.8 h compared with 8 h in ISIS-4) also failed to show a decrease on 30-day mortality rates (2). Indeed, a recent meta-analysis within the Cochrane collaboration concludes that there is no beneficial effect of Mg 2ϩ on mortality in AMI patients (OR 0.99, 95% CI 0.94 to 1.04) (312). However, it should be noted that the ISIS-4 study provides 72% of the power in this analysis and that the Mg 2ϩ doses used within the analyzed studies differ significantly.…”

Estimating required information size by quantifying diversity in random-effects model meta-analyses

“…These meta-analyses cover a range of inconsistency, I 2 , from 0% to 74.2% and come from different medical research fields: intensive care [16], assisted reproductive technology [17], perioperative medicine [19,22], neonatology [18,20], and cardiology [21]. The results of the calculations of I 2 , D 2 , inconsistency-adjusted information size HIS (), and diversity-adjusted information size DIS () from these meta-analyses are shown in Table 2.…”

Comment to “Recommendation on an updated standardization of serum magnesium reference ranges”

“…Although cohort studies can be indicative of a positive effect of magnesium on human health, randomized controlled clinical (interventional) trials are required to prove first and foremost causality, and whether correcting serum magnesium towards a specific target value is therapeutic or preventive. A systematic review and meta-analysis of the effect of intravenous magnesium supplementation on myocardial infarction demonstrates that magnesium is not beneficial [14]. Similar outcomes were shown for stroke, as intravenous Mg 2+ supplementation did not improve mortality in patients with stroke [15].…”

Magnesium in Man: Implications for Health and Disease

“…However, also a second large-scale randomized double-blind study with 6,213 patients and an earlier time point of Mg 2ϩ infusion (3.8 h compared with 8 h in ISIS-4) also failed to show a decrease on 30-day mortality rates (2). Indeed, a recent meta-analysis within the Cochrane collaboration concludes that there is no beneficial effect of Mg 2ϩ on mortality in AMI patients (OR 0.99, 95% CI 0.94 to 1.04) (312). However, it should be noted that the ISIS-4 study provides 72% of the power in this analysis and that the Mg 2ϩ doses used within the analyzed studies differ significantly.…”

Estimating required information size by quantifying diversity in random-effects model meta-analyses

“…These meta-analyses cover a range of inconsistency, I 2 , from 0% to 74.2% and come from different medical research fields: intensive care [16], assisted reproductive technology [17], perioperative medicine [19,22], neonatology [18,20], and cardiology [21]. The results of the calculations of I 2 , D 2 , inconsistency-adjusted information size HIS (), and diversity-adjusted information size DIS () from these meta-analyses are shown in Table 2.…”

Comment to “Recommendation on an updated standardization of serum magnesium reference ranges”

“…Although cohort studies can be indicative of a positive effect of magnesium on human health, randomized controlled clinical (interventional) trials are required to prove first and foremost causality, and whether correcting serum magnesium towards a specific target value is therapeutic or preventive. A systematic review and meta-analysis of the effect of intravenous magnesium supplementation on myocardial infarction demonstrates that magnesium is not beneficial [14]. Similar outcomes were shown for stroke, as intravenous Mg 2+ supplementation did not improve mortality in patients with stroke [15].…”

Magnesium in Man: Implications for Health and Disease

“…However, also a second large-scale randomized double-blind study with 6,213 patients and an earlier time point of Mg 2ϩ infusion (3.8 h compared with 8 h in ISIS-4) also failed to show a decrease on 30-day mortality rates (2). Indeed, a recent meta-analysis within the Cochrane collaboration concludes that there is no beneficial effect of Mg 2ϩ on mortality in AMI patients (OR 0.99, 95% CI 0.94 to 1.04) (312). However, it should be noted that the ISIS-4 study provides 72% of the power in this analysis and that the Mg 2ϩ doses used within the analyzed studies differ significantly.…”

Estimating required information size by quantifying diversity in random-effects model meta-analyses

“…These meta-analyses cover a range of inconsistency, I 2 , from 0% to 74.2% and come from different medical research fields: intensive care [16], assisted reproductive technology [17], perioperative medicine [19,22], neonatology [18,20], and cardiology [21]. The results of the calculations of I 2 , D 2 , inconsistency-adjusted information size HIS (), and diversity-adjusted information size DIS () from these meta-analyses are shown in Table 2.…”