Significance of serum magnesium levels in reference to acute myocardial infarction and role of intravenous magnesium therapy in prevention of cardiac arrhythmias following myocardial infarction

Mhaskar, Dhanesh; Mahajan, Sanket K; Pawar, Komal Channappa

doi:10.4103/2230-8598.118969

Cited by 3 publications

(4 citation statements)

References 12 publications

(12 reference statements)

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“…Table 2 represents the total rate of arrhythmias after meta-analysis of the extracted data. As seen in this table, thirteen studies [ 12 – 14 , 16 – 20 , 23 , 27 , 29 , 31 , 32 ] included for evaluating the prevalence of the ventricular arrhythmia. The prevalence of ventricular tachycardia in the group receiving magnesium sulfate and placebo was 5.67% (95% CI, 1.38–11.97) and 15.04% (95% CI, 6.47–26.06) respectively.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis

Salaminia

Sayehmiri

Angha

et al. 2018

BMC Cardiovasc Disord

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BackgroundAtrial and ventricular cardiac arrhythmias are one of the most common early complications after cardiac surgery and these serve as a major cause of mortality and morbidity after cardiac revascularization. We want to evaluate the effect of magnesium sulfate administration on the incidence of cardiac arrhythmias after cardiac revascularization by doing this systematic review and meta-analysis.MethodsThe search performed in several databases (SID, Magiran, IranDoc, IranMedex, MedLib, PubMed, EmBase, Web of Science, Scopus, the Cochrane Library and Google Scholar) for published Randomized controlled trials before December 2017 that have reported the association between Magnesium consumption and the incidence of cardiac arrhythmias. This relationship measured using odds ratios (ORs) with a confidence interval of 95% (CIs). Funnel plots and Egger test used to examine publication bias. STATA (version 11.1) used for all analyses.ResultsTwenty-two studies selected as eligible for this research and included in the final analysis. The total rate of ventricular arrhythmia was lower in the group receiving magnesium sulfate than placebo (11.88% versus 24.24%). The same trend obtained for the total incidence of supraventricular arrhythmia (10.36% in the magnesium versus 23.91% in the placebo group). In general the present meta-analysis showed that magnesium could decrease ventricular and supraventricular arrhythmias compared with placebo (OR = 0.32, 95% CI 0.16–0.49; p < 0.001 and OR = 0.42, 95% CI 0.22–0.65; p < 0.001, respectively). Subgroup analysis showed that the effect of magnesium on the incidence of cardiac arrhythmias was not affected by clinical settings and dosage of magnesium. Meta-regression analysis also showed that there was no significant association between the reduction of ventricular arrhythmias and sample size.ConclusionThe results of this meta-analysis study suggest that magnesium sulfate can be used safely and effectively and is a cost-effective way in the prevention of many of ventricular and supraventricular arrhythmias.

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Section: Resultsmentioning

confidence: 99%

Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis

Salaminia

Sayehmiri

Angha

et al. 2018

BMC Cardiovasc Disord

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“…Evaluation of serum magnesium levels in the blood in patients with DM will reduce the risk of complications of ACS.Hypomagnesemia, as seen in the study by Mhaskar et al, (2013) and Sugunakar et al, (2014), related to ACS and the incidence of arrhythmias. 3,4 As many as 10 out of 37 (27%) study samples of Sugunakar et al, (2014) experienced death from myocardial infarction.This proves that hypomagnesaemia is a chronic effect of DM and is associated with increased risk of ACS.…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Magnesium Level with Acute Coronary Syndrome (ACS) in Diabetes Mellitus (DM) Patients

Wulansari

Soelistijo

Lefi

2019

BHSJ

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Introduction: Until now, cardiovascular complications are still the highest cause of death and disability in DM patients. Hypomagnesemia in DM accelerate atherosclerosis and can cause instability and plaque rupture which can lead to acute coronary syndrome.Methods: Design of this study was observational analytic using a "case control" study involved 76 samples of DM patients, consisting of 38 samples with SKA (+) and 38 samples with SKA (-). Subjects of this study were all DM patients in the period July-December 2018 in the Emergency Room (ER) and Outpatient Installation of Endocrine at the RSUD Dr. Soetomo Surabaya, which fulfills the criteria for inclusion and exclusion. Demographic data and clinical characteristics are presented descriptively. If data is normally distributed then an unpaired t test is carried out and if the data is not normally, distributed with Mann Whitney test is performed. The statistical test was stated to be significant if p <0.05. The association between hypomagnesemia and the incidence of ACS a multivariate logistic regression test was performed, the risk number was in the form of odds ratios (OR). Results: This study involved 76 subjects with diabetes mellitus with SKA and non SKA 38 subjects. The mean serum magnesium level in the ACS group was lower than non ACS (1.9 mg / dL vs. 2.1 mg / dL), hypomagnesemia cut-off of <2.08 mg / dL. In this study hypomagnesemia as a risk factor for the incidence of ACS in DM patients with OR 2.8 (CI 1.1-7.6; p = 0.039).Conclusion: Magnesium levels in the ACS group were lower than the non ACS group. Hypomagnesemia Increase The Incidence of Acute Coronary Syndrome in Diabetes Mellitus Patients.

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“…ST-segment elevation needs to be correlated clinically. ST-Elevation greater than one mm in at least 2 adjacent limb leads, ST-elevation greater than two mm in at least two adjoining precordial leads may need emergency reperfusion therapy (Mhaskar et al, 2013;Chandran et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…A Coronary Prognostic Index (CPI) was developed to assess the outcome in the cases of ACS (Peel et al, 1962). There are always chances of a sudden unexpected death, even in patients who are having a positive recovery and thus the prognostication needs a close watch over such patients (Mhaskar et al, 2013;Chandran et al, 2020). CPI is an easily usable index where bedside clinical findings are used.…”

Section: Introductionmentioning

confidence: 99%

Serum Magnesium as a prognostic marker in acute coronary syndromes and its correlation with coronary prognostic index

Annadatha¹,

Varma²,

Acharya³

et al. 2023

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Aim: The aim is to evaluate Serum Magnesium as a prognostic marker in Acute Coronary Syndromes (ACS) and to compare with Coronary Prognostic Index (CPI). Methods: This case control study conducted in the intensive care unit (ICU) of AVBRH, Sawangi, Wardha taking 150 cases of ACS and 150 healthy age and sex matched controls. CPI was calculated in the cases of ACS and Serum Magnesium was calculated on admission for cases and controls and was compared between them. P value of <0.05 was taken as significant.Results: 6% of the cases gave history of myocardial infarction and 22% gave history of Angina and 34.6% gave history of smoking. Mean levels of serum Magnesium on admission (mg/dL) in cases was 1.82 ± 0.29 and among controls was 1.86 ± 0.23 with no significant difference between them. The prevalence of Hypomagnesemia was seen in 30% of cases and 19.33% of controls. Significant negative correlation was seen between serum Magnesium levels on admission with CPI with correlation coefficient of (r=-0.293, p<0.01).Mean ± SD of CPI in patients with hypomagnesemia was 10.42 ± 5.36 which was significantly higher as compared to patients without hypomagnesemia (7.3± 3.34). Conclusion: This study concluded that MI was more prevalent among the male population than the female population. Hypertension, smoking, alcohol and diabetes are the common independent risk factors for ACS. Serum Magnesium levels can be predictive of severity of outcome in cases of ACS and is correlated negatively with CPI.

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Significance of serum magnesium levels in reference to acute myocardial infarction and role of intravenous magnesium therapy in prevention of cardiac arrhythmias following myocardial infarction

Cited by 3 publications

References 12 publications

Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis

Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis

Association between Serum Magnesium Level with Acute Coronary Syndrome (ACS) in Diabetes Mellitus (DM) Patients

Serum Magnesium as a prognostic marker in acute coronary syndromes and its correlation with coronary prognostic index

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