2016
DOI: 10.14202/vetworld.2016.1429-1434
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Intravenous administration of puppy deciduous teeth stem cells in degenerative valve disease

Abstract: Aim:The objective of this study is to investigate the improvement of heart function in dogs with chronic valvular heart disease after puppy deciduous teeth stem cells (pDSCs) administration.Materials and Methods:20 client-owned dogs with degenerative valvular heart disease underwent multiple intravenous injections of allogeneic pDSCs. Dogs were randomly assigned to two groups: (i) Control group (n=10) with standard treatment for heart failure and (ii) group with standard treatment and multiple administrations … Show more

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Cited by 11 publications
(8 citation statements)
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“…Mesenchymal stem cells are also capable of migrating to sites of inflammation following intravenous administration, as previous studies have demonstrated. [31][32][33] Chemokines such as SDF-1 34 and MCP-1 35 released by inflammatory stimuli provide a potent stimulus for mesenchymal stem cell recruitment, and these cytokines are known to be produced in the joints of animals with osteoarthritis. 36,37 Pulmonary trapping may interfere with this function, 38,39 which may explain why mesenchymal stem cells were detected in the joint fluid of only four dogs in our study.…”
Section: Discussionmentioning
confidence: 99%
“…Mesenchymal stem cells are also capable of migrating to sites of inflammation following intravenous administration, as previous studies have demonstrated. [31][32][33] Chemokines such as SDF-1 34 and MCP-1 35 released by inflammatory stimuli provide a potent stimulus for mesenchymal stem cell recruitment, and these cytokines are known to be produced in the joints of animals with osteoarthritis. 36,37 Pulmonary trapping may interfere with this function, 38,39 which may explain why mesenchymal stem cells were detected in the joint fluid of only four dogs in our study.…”
Section: Discussionmentioning
confidence: 99%
“…In smaller dog breeds, the most common cardiac disease is the degenerative valvular disease, which is often complicated by ventricular dilation and dysfunction (233). Petchdee and Sompeewong investigated the effect of IV administration of puppy deciduous teeth derived stem cells on the degenerative valvular disease (234). Their results showed an improvement in the left ventricular ejection fraction, but this was a small study, and more studies will be needed to establish any potential positive effects.…”
Section: Cardiac Diseasesmentioning
confidence: 99%
“…Furthermore, the use of allogeneic MSC has shown to be effective and safe in canine diseases [26]. In addition, adult MSCs exhibit attractive immunomodulatory properties in degenerative diseases in animals [27]. This is the case of ASCs, a type of MSC, which in addition to the cellular and molecular traits of BM-MSC, exhibits robust immunosuppressive activity, mediated by induction of the production of Tregs [28] and the selective release of several types of growth factors [29][30][31][32][33].…”
Section: Introductionmentioning
confidence: 99%