Intravenous Administration of Butaphosphan and Cyanocobalamin Combination to Late-Pregnant Dairy Cows Reduces Their Insulin Resistance After Calving

Chalmeh, Aliasghar; Pourjafar, Mehrdad; Badiei, Khalil; Jalali, Mehrdad; Sebdani, Mohammad Mazrouei

doi:10.1007/s12011-020-02330-5

Cited by 4 publications

(9 citation statements)

References 45 publications

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“…However, no significant effect of iBC on blood BHBA was observed by others (Gordon et al 2017a;Gordon et al 2017b) in SCK treatment with a much lower dosage, whereas Rollin et al (2010) reported a significant reduction of blood BHBA concentration with similar dosage in multiparous dairy cows. Increased blood glucose concentration was reported by Chalmeh et al (2020), Furll et al (2010), Deniz et al (2009b) and Krdzalic and Curcic (1976) after iBC treatment at pre-, peri-and the postpartum period in dairy cow, but there are also studies in those no effect of iBC was observed on blood glucose (Tables 1, 2, 3). Thus, the effect of iBC on blood glucose concentration in transition cows can be multifactorial and needs to be studied in detail.…”

Section: Evidences About the Mode Of Action Of Ibcmentioning

confidence: 83%

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

Denız¹,

Aksoy²

2022

Vet. Med. - Czech

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Phosphorus is critical for life and an indispensable element for biologically occurring organic molecules such as DNA, ATP, and phosphoproteomes. Butafosfan is a synthetically produced organic phosphorous (phosphonic acid) compound that contains 17.3% phosphorus. It does not belong to the group of biologically occurring organic phosphorous compounds. Butafosfan has been used in many animal species as a metabolic stimulant interfering with energy metabolism. Vitamin B12 (VB12) is a unique cobalt-containing vitamin. It functions as a cofactor for the enzymes methionine synthase and methyl-malonyl-CoA mutase. It is necessary for the conversion of propionate into succinyl-CoA in ruminants. A combination of butafosfan and VB12 (iBC) has been available for veterinary use since 1958 and the first publication appeared in the 1970s in cows. However, the first molecular biological studies about its mode of action appeared in early 2000s. Recent studies revealed that iBC has significant effects on carbohydrate and lipid metabolism. Investigations between 1970 and 1994 focused mainly on cows at risk of metabolic and reproductive disease in the dry period. Studies as of 2000 investigated its efficacy for the prevention and treatment of subclinical and secondary ketosis, adjunctive/supportive therapy for displaced abomasum operation, milk fever, improvement of postoperative rumen activity, uterus involution, and mastitis in transition dairy cows.

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Section: Evidences About the Mode Of Action Of Ibcmentioning

confidence: 83%

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

Denız¹,

Aksoy²

2022

Vet. Med. - Czech

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“…На сьогодні більшість вітчизняних виробників ветеринарних препаратів вдаються до виробництва генеричних препаратів (препаратів-аналогів) різних фармацевтичних груп. Для підвищення стійкості до стресових ситуацій, профілактики захворювань, підвищення резистентності, збереженості та продуктивності сільськогосподарських тварин спеціалістами ветеринарної медицини широко використовуються ветеринарні препарати та біологічно активні кормові добавки (Zhyla et al, 2015;Chalmeh et al, 2020).…”

Section: вступunclassified

“…Ефективність комбінації бутафосфану та ціанокобаламіну досліджена й описана в науковій літературі (Kreipe et al, 2011;Nuber et al, 2015;Chalmeh et al, 2020). На ринку присутні ветеринарні препарати з комбінацією бутафосфану та ціанокобаламіну, такі як Катозал ("Bayer HealthCare LLC", США), Ціанофор (ТОВ "Ветсинтез", м. Харків), Ветозал (O.L.KAR, м. Шаргород).…”

Section: вступunclassified

The efficiency of the drug based on butaphosphane, B vitamins and L-carnitine in the treatment of horses

et al. 2021

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An important feature of living organisms, acquired in the process of evolution, is the ability to adapt to various external influences and changes in the environment, to maintain homeostasis and regulatory processes in organs, systems and the body as a whole. However, with modern breeding technologies, the physiological capabilities of the animal's body are often unable to change as quickly as required by the conditions of industrial maintenance, which leads to stress. Vitamin preparations and biologically active feed additives are widely used by veterinary medicine specialists to increase resistance to stressful situations, disease prevention, increase resistance, safety and productivity of farm animals. Preparation L-tsyn, solution for injection (manufactured by BIOTESTLAB LLC), is a drug, the action of which is due to the prescription combination of active substances, namely: butaphosphane, B vitamins (vitamin B12, vitamin B3) and L-carnitine. The aim of the study was to investigate the effectiveness of the drug L-tsyn on horses under the influence of stressors of various natures. Two experiments on working horses with constant, excessive physical activity with chronic exercises and with complex therapy of intoxication with signs of acute renal failure in horse were conducted. Clinical trials of the drug were performed on working horses aged 5–15 years, of different sexes. The drug was administered in a dose of 20–25 ml per animal, 1 time per day for 5 consecutive days. The clinical condition of the experimental animals was observed for 21 days from the start of the drug. The morpho-functional state of the animal's body before and after the drug was established according to the indicators of the clinical condition, morphological and biochemical parameters of the blood, which were determined according to generally accepted methods. In working horses under excessive load the drug L-tsyn activated the processes of hematopoiesis, improved the physiological state of the body and contributed to the increase the general tone of the body. The drug as part of complex therapy in the treatment of intoxication, showed hepato- and nephroprotective properties, reduced the manifestations of intoxication, helped to restoration of the animal’s normal physiological state. According to the results of clinical, hematological and biochemical studies, it can be concluded that the drug L-tsyn has a stimulating effect on metabolic processes in the animals’ body, shows tonic properties, increases the body's resistance to toxins and adverse environmental factors and can be used as monotherapy and for the complex treatment of diseases of various etiologies in horses.

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“…Herein, insulin was not measured, but the assessment of insulin resistance via conventional methods can help better understand the function of this drug and its effects on metabolism. In a study by Chalmeh et al (2021), insulin resistance was lower in cows receiving higher doses of butaphosphan and cyanocobalamin than in other treatments and Ctrl groups and a similar study could be conducted to better evaluate the metabolic effects of butaphosphan and cyanocobalamin in sheep. In general, sheep at the end of pregnancy, especially those with more than one embryo, experience a negative energy balance, and their bodies utilise stored fat to compensate.…”

Section: Treatmentmentioning

confidence: 99%

“…Improvements in the energy status of animals treated with these substances have been reported (Rollin et al, 2010). In addition, previous studies have revealed that this combination can be effective in reducing the occurrence of negative energy balance and insulin resistance in dairy cows (Chalmeh et al, 2021). However, it is not yet clear whether this form of phosphorus is biologically available to animals (Rollin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

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Background: Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.Objectives: It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.Methods: Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition.A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low-and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.Results: This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others. Conclusions:It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.

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Intravenous Administration of Butaphosphan and Cyanocobalamin Combination to Late-Pregnant Dairy Cows Reduces Their Insulin Resistance After Calving

Cited by 4 publications

References 45 publications

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

Use of organic phosphorous butafosfan and vitamin B12 combination in transition dairy cows

The efficiency of the drug based on butaphosphane, B vitamins and L-carnitine in the treatment of horses

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

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