Intravascular photoacoustic imaging using an IVUS imaging catheter

Sethuraman, Shriram; Aglyamov, Salavat R.; Amirian, James; Smalling, Richard W.; Emelianov, Stanislav

doi:10.1109/tuffc.2007.343

Cited by 168 publications

(139 citation statements)

References 24 publications

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“…To further assess the vulnerability of the plaques, we previously introduced intravascular photoacoustic ͑IVPA͒ imaging. [15][16][17][18][19][20][21] Photoacoustic imaging utilizes light absorption properties of tissues. After excitation of the tissues by short laser pulses, consequent acoustic transients generated as a result of thermal expansion are detected.…”

Section: Introductionmentioning

confidence: 99%

“…[25][26][27][28][29][30] Previously, we investigated the feasibility of IVPA imaging using commercially available IVUS imaging catheters. 15 The excised tissue samples were imaged with the IVUS catheter located inside of a lumen, while the vessel was externally irradiated, and the capability of the combined IVUS/IVPA imaging to detect and differentiate atherosclerotic plaques was demonstrated. 17,18 However, for clinical use, an artery with atherosclerotic plaques must be irradiated internally.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a catheter for combined intravascular ultrasound and photoacoustic imaging

Karpiouk¹,

Wang²,

Emelianov³

2010

Review of Scientific Instruments

113

119

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Atherosclerosis is characterized by formation and development of the plaques in the inner layer of the vessel wall. To detect and characterize atherosclerotic plaques, we previously introduced the combined intravascular ultrasound ͑IVUS͒ and intravascular photoacoustic ͑IVPA͒ imaging capable of assessing plaque morphology and composition. The utility of IVUS/IVPA imaging has been demonstrated by imaging tissue-mimicking phantoms and ex vivo arterial samples using laboratory prototype of the imaging system. However, the clinical realization of a IVUS/IVPA imaging requires an integrated intravascular imaging catheter. In this paper, two designs of IVUS/IVPA imaging catheters-side fire fiber-based and mirror-based catheters-are reported. A commercially available IVUS imaging catheter was utilized for both pulse-echo ultrasound imaging and detection of photoacoustic transients. Laser pulses were delivered by custom-designed fiber-based optical systems. The optical fiber and IVUS imaging catheter were combined into a single device. Both designs were tested and compared using point targets and tissue-mimicking phantoms. The results indicate applicability of the proposed catheters for clinical use.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a catheter for combined intravascular ultrasound and photoacoustic imaging

Karpiouk¹,

Wang²,

Emelianov³

2010

Review of Scientific Instruments

113

119

View full text Add to dashboard Cite

show abstract

“…7,8 The thermal expansion of heated tissues generates photoacoustic transients that can be detected by the same ultrasound transducer used for ultrasound imaging. Given the synergy of ultrasound and photoacoustic imaging, ultrasound-guided intravascular photoacoustic (IVPA) imaging 9,10 capable of identifying tissue composition based on tissue's optical properties has been demonstrated. [11][12][13] Furthermore, imaging contrast agents were explored to identify molecular and cellular signatures associated with atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17][18] Compared to IVUS imaging, IVPA has a similar imaging depth of several millimeters and imaging resolution within one hundred micrometers. 10 IVPA imaging was combined with IVUS imaging thus visualizing both morphology and composition of soft tissues. Recently, combined IVUS/IVPA imaging was used ex vivo to characterize plaque composition including lipid and macrophages.…”

Section: Introductionmentioning

confidence: 99%

Feasibility ofin vivointravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

et al. 2012

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Abstract. Pilot studies of in vivo combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging are reported. A recently introduced prototype of an integrated IVUS/IVPA imaging catheter consisting of a single-element ultrasound transducer and a light delivery system based on a single optical fiber was adapted and used for in vivo imaging of a coronary stent deployed in a rabbit's thoracic aorta in the presence of luminal blood. The results suggest that in vivo IVUS/IVPA imaging is feasible using the integrated IVUS/IVPA imaging catheter. The challenges of in vivo combined IVUS/IVPA imaging are discussed, and further improvements on the design of the catheter and the clinical imaging system are proposed.

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“…The imaging technique was shown to be applicable for intraluminal imaging (Sethuraman et al 2006). Further, the synergistic combination of intravascular photoacoustic (IVPA) imaging with IVUS is expected to play an important role in detecting and differentiating vulnerable atherosclerotic plaques (Sethuraman et al 2006;Sethuraman et al 2007). Indeed, the difference in the optical absorption coefficient between various components of the heterogeneous plaque (lipids, calcium, macrophages, blood, and collagen) could provide the contrast in IVPA imaging.…”

Section: Introductionmentioning

confidence: 99%

Remote Temperature Estimation in Intravascular Photoacoustic Imaging

Sethuraman

Aglyamov

Smalling

et al. 2008

Ultrasound in Medicine & Biology

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Intravascular photoacoustic (IVPA) imaging is based on the detection of laser-induced acoustic waves generated within the arterial tissue under pulsed laser irradiation. Generally, laser radiant energy levels are kept low (20 mJ/cm 2 ) during photoacoustic imaging to conform to general standards for safe use of lasers on biological tissues. However, safety standards in intravascular photoacoustic imaging are not yet fully established. Consequently, monitoring spatio-temporal temperature changes associated with laser-tissue interaction is important to address thermal safety of IVPA imaging. In this study we utilize the IVUS based strain measurements to estimate the laser induced temperature increase. Temporal changes in temperature were estimated in a phantom modeling a vessel with an inclusion. A cross-correlation based time delay estimator was used to assess temperature induced strains produced by different laser radiant energies. The IVUS based remote measurements revealed temperature increases of 0.7±0.3°C, 2.9±0.2 °C and 5.0±0.2 °C, for the laser radiant energies of 30 mJ/cm 2 , 60 mJ/cm 2 and 85 mJ/cm 2 respectively. The technique was then used in imaging of ex vivo samples of a normal rabbit aorta. For arterial tissues, a temperature elevation of 1.1°C was observed for a laser fluence of 60 mJ/cm 2 and lesser than 1°C for lower energy levels normally associated with IVPA imaging. Therefore, the developed ultrasound technique can be used to monitor temperature during IVPA imaging. Furthermore, the analysis based on the Arrhenius thermal damage model indicates no thermal injury in the arterial tissue; suggesting the safety of IVPA imaging

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Intravascular photoacoustic imaging using an IVUS imaging catheter

Cited by 168 publications

References 24 publications

Development of a catheter for combined intravascular ultrasound and photoacoustic imaging

Development of a catheter for combined intravascular ultrasound and photoacoustic imaging

Feasibility ofin vivointravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

Remote Temperature Estimation in Intravascular Photoacoustic Imaging

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