Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network

Deyssenroth, Maya A.; Gennings, Chris; Liu, Shelley H.; Peng, Shouneng; Hao, Ke; Lambertini, Luca; Jackson, Brian P.; Karagas, Margaret R.; Marsit, Carmen J.; Chen, Jia

doi:10.1016/j.envint.2018.08.010

Cited by 53 publications

(39 citation statements)

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“…The official guidelines by governmental agencies are skewed, biased and often laced with deception and cover ups on disease causes (eg, SIDS, vaccine injuries, drug toxicities, clinical trials on exclusion/inclusion criteria). Often official information is not worthy of serious considerations once the scientific pros and cons are weighed, particularly regarding information on root causes of cancer epidemics, over‐, under‐diagnosis of diseases, toxicities of drugs, biologics or vaccines safety 1–10,17,20–23,50–52,64,69,71,93,136,137,140,141,157,164,177,192 , , , , . Often, credible scientific information that is prepared by scientists who work in the government or academia are ignored, dismissed or abused when members of the establishment decide to publicize drugs or vaccines of their choice 1‐8,10‐13,17,18,34,36‐39,64,69,71,77,94,143,149,169,172,176,178,180‐184,186‐197 …”

Section: Vaccine Toxicities: Retardation Of Mitochondria and Immune Rmentioning

confidence: 99%

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Khatami

2020

Clinical & Translational Med

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Schematic representation of cause, exacerbation and consequence of vaccinesinduced diverse immune disorders in immune-responsive or immune-privileged tissues. It depicts that vaccination of the unborn, alter biology of trophoblastembryo-fetus-placenta and orderly growth and development affecting epithelialmesenchymal transition, proper expression of constituent-inducible receptor molecules; consequently influence immunity of newborn, infant, children and adults. Vaccine-induced impaired organ development and immunity include impaired mitochondrial function (mitophagy), tissue bioenergetics, loss of balance in Yin (tumoricidal) and Yang (tumorigenic) pathways and altered metabolic-neuronal-hormonal activities as bases for increased induced diseases in young and old.

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Section: Vaccine Toxicities: Retardation Of Mitochondria and Immune Rmentioning

confidence: 99%

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Khatami

2020

Clinical & Translational Med

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“…For this analysis, the link function g(μ) was assumed to be a logit link because of the binary nature of the outcome variable (pathology status), the chemicals included in the WQS index were scored according to quartiles and q i = 0, 1, 2, or 3 if the concentration value was in 1st, 2nd, 3rd and 4th quartile, respectively and 500 bootstrap samples were generated from our full data set to estimate the weights w i . WQS models were constructed with β 1 constrained to be non-negative and additional models were computed with β 1 constrained to be non-positive to determine whether some pollutants were associated with reduced risk for thyroid pathologies (Deyssenroth et al, 2018). Finally, the parameters estimates computed with each imputed dataset were combined according the formula of Rubin (Rubin, 2004;Lubin et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Association between mixture of persistent organic pollutants and thyroid pathologies in a Belgian population

Dufour

Pirard

Pétrossians

et al. 2020

Environmental Research

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Previous years, the incidence of autoimmune thyroid diseases has increased worldwide. The presence of many pollutants in the environment suspected to be thyroid disruptors may have contributed to the observed increase. Unfortunately, the results from epidemiological studies assessing the association between pollution and thyroid disorders remain inconsistent, maybe due to a nearly complete neglect of the mixture effect. The blood levels of 12 brominated flame retardants, 3 polychlorinated biphenyls, 16 organochlorine pesticides, 7 perfluoroalkyl substances and 16 phenolic organohalogens were measured in 35 hypothyroid and 44 hyperthyroid volunteers and in 160 individuals from the general population designed as controls. Weighted quantile sum (WQS) regressions were performed to compute indexes representing the mixture of POPs, and we assessed the relations with thyroid disorders. Nineteen pollutants were detected in more than 40% of the individuals and were thus included in the WQS indexes. The WQS index was statistically significantly associated with an increased odds of hypothyroidism (odds ratio (OR) = 98.1; 95% CI: 5.51-1747) with the highest weights attributed to PCB 138 (w = 0.210), 3-OH-CB 180 (w = 0.197), 4-OH-CB 146 (w = 0.188), 4',4-DDE (w = 0.156) while there were no evidence of a relation with increased odds of hyperthyroidism. Given the relative low number of individuals included in the present investigation, standard WQS methodology could not be used, this study should thus be considered as a preliminary, hypothesis-generating study. Nevertheless, these results highlighted the importance of considering the potential effect of chemical mixture when studying endocrine disruptors.

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“…One of the analytic approaches developed specifically for estimating effects of exposure mixtures, weighted quantile sum (WQS) regression, has become increasingly used as an analytic approach for exposure mixtures in relation to health outcomes (Yorita Christensen et al 2013;Deyssenroth et al 2018;Nieves et al 2016). This approach is based on developing an exposure index that is a weighted average of all exposures of interest after each exposure is transformed into a categorical variable defined by quantiles of the exposures.…”

Section: Introductionmentioning

confidence: 99%

A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures

Keil

Buckley

O’Brien

et al. 2020

Environ Health Perspect

752

393

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BACKGROUND: Exposure mixtures frequently occur in data across many domains, particularly in the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer questions about exposure mixtures, including methods such as weighted quantile sum (WQS) regression that estimate a joint effect of the mixture components. OBJECTIVES: We demonstrate a new approach to estimating the joint effects of a mixture: quantile g-computation. This approach combines the inferential simplicity of WQS regression with the flexibility of g-computation, a method of causal effect estimation. We use simulations to examine whether quantile g-computation and WQS regression can accurately and precisely estimate the effects of mixtures in a variety of common scenarios. METHODS: We examine the bias, confidence interval (CI) coverage, and bias-variance tradeoff of quantile g-computation and WQS regression and how these quantities are impacted by the presence of noncausal exposures, exposure correlation, unmeasured confounding, and nonlinearity of exposure effects. RESULTS: Quantile g-computation, unlike WQS regression, allows inference on mixture effects that is unbiased with appropriate CI coverage at sample sizes typically encountered in epidemiologic studies and when the assumptions of WQS regression are not met. Further, WQS regression can magnify bias from unmeasured confounding that might occur if important components of the mixture are omitted from the analysis. DISCUSSION: Unlike inferential approaches that examine the effects of individual exposures while holding other exposures constant, methods like quantile g-computation that can estimate the effect of a mixture are essential for understanding the effects of potential public health actions that act on exposure sources. Our approach may serve to help bridge gaps between epidemiologic analysis and interventions such as regulations on industrial emissions or mining processes, dietary changes, or consumer behavioral changes that act on multiple exposures simultaneously. https://doi.

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Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network

Abstract: We present a novel approach that integrates the application of advanced bioinformatics and biostatistics methods to delineate potential placental pathways through which trace metal exposures impact fetal growth.

Cited by 53 publications

References 50 publications

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Association between mixture of persistent organic pollutants and thyroid pathologies in a Belgian population

A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures

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