Intrascleral fibrin glue intraocular lens fixation combined with Descemet-stripping automated endothelial keratoplasty or penetrating keratoplasty

Sinha, Rajesh; Shekhar, Himanshu; Sharma, Namrata; Tandon, Radhika; Titiyal, Jeewan S; Vajpayee, Rasik B

doi:10.1016/j.jcrs.2012.02.042

Cited by 27 publications

(41 citation statements)

References 25 publications

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“…The largest number of references concentrated on using fibrin sealant to assist with intraocular lens fixation. Successful use of fibrin sealant to secure positioning of a posterior chamber intraocular lens is a known technique in ophthalmology with the new contributions suggesting: reduced complications in a series ( n = 50) of cases [127] versus suture fixation (7/25, 28% versus 14/25, 56%, P = 0.045); successful use [128] in children with the caveat that use in ectopia lentis in Marfan's Syndrome may have a high incidence of associated retinal detachment [129, 130]; intrascleral haptic lens fixation (for a previously placed posterior chamber intraocular lens) with corneal transplantation (penetrating keratoplasty or Descemet-stripping automated endothelial keratoplasty) for aphakic or pseudophakic bullous keratopathy [131]; and fixation of subluxated or decentered previously placed posterior chamber intraocular lens using the assistance of haptics [132, 133]. …”

Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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“…The various modifications that can be employed to overcome these difficulties are simultaneous DSAEK and IOLs implantation,[94] insertion of an infusion cannula through pars plana route,[95] or placement of temporary anchor sutures to prevent donor dislodgement and improve graft adherence. [96]…”

Section: Descemet Stripping Automated Endothelial Keratoplasty In Spementioning

confidence: 99%

Descemet stripping automated endothelial keratoplasty

Sharma

Maharana

Singhi

et al. 2017

Indian J Ophthalmol

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Endothelial keratoplasty is at present the gold standard for surgical treatment of corneal endothelial pathologies not associated with significant corneal scar. Tremendous progress has been made in recent years in improving the technology of endothelial keratoplasty techniques, such as descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane endothelial keratoplasty. In this review, we discuss the current techniques and outcomes of DSAEK.

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“…The applications of endothelial keratoplasty are continually expanding and it is increasingly being performed in complex cases. [1617181920] A repeat graft is one of the most frequent indications for keratoplasty, and a re-DSAEK after failed PKP or DSAEK is safe and may be associated with superior visual outcomes. [111221] However, graft survival progressively diminishes with the increase in the number of regrafts, and good decision-making regarding the type of keratoplasty procedure is essential to ensure long-term graft survival and good functional outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Successful visual and anatomical outcomes with DSAEK have been reported in CHED, bee sting–induced decompensation, and SFIOL. [161718] However, these cases may be more suitable for a primary PKP instead of DSAEK, and a more conservative approach may be advisable during the initial decision-making to ensure optimal outcomes and minimize the incidence of graft failure. Long-term endothelial cell loss and graft failures have been reported to be significantly higher after DSAEK with ACIOL, further highlighting the necessity for careful decision-making.…”

Section: Discussionmentioning

confidence: 99%

Repeat keratoplasty in failed Descemet stripping automated endothelial keratoplasty

Kaur

Titiyal

Gagrani

et al. 2019

Indian J Ophthalmol

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Purpose:To evaluate the clinical factors associated with repeat Descemet stripping automated endothelial keratoplasty (DSAEK) or penetrating keratoplasty (PKP) in cases of failed DSAEK.Methods:Retrospective observational study of cases with failed DSAEK admitted to our center for a repeat keratoplasty over 5 years (January 2013–Decemeber 2017) was undertaken. Demographic and perioperative details of all cases and type of repeat keratoplasty were recorded. Logistic regression analysis was performed to analyze the factors affecting the type of repeat keratoplasty.Results:A total of 94 eyes with failed DSAEK were evaluated. Repeat DSAEK was performed in 66% and PKP in 34% of cases. Significantly increased odds for requiring PKP were observed in association with stromal scarring [odds ratio (OR) = 2.9, P = 0.018)], trainee surgeons (OR = 4.05, P = 0.008), intraoperative complications (OR = 4.58, P = 0.003), scleral fixated intraocular lens or anterior chamber intraocular lens in situ (OR = 33.8, P < 0.001), secondary glaucoma (OR = 3.02, P = 0.015), peripheral anterior synechiae (OR = 8.6, P < 0.001), preoperative corneal thickness (OR = 1.01, P < 0001), time to primary surgery (OR = 1.03, P = 0.03), post-DSAEK host thickness (OR = 1.01, P < 0.001), and time interval from graft failure to regraft (OR = 1.18, P < 0.001). All eyes with congenital hereditary endothelial dystrophy, bee-sting-induced corneal decompensation, Axenfeld-Rieger syndrome, and multiple failed grafts underwent secondary PKP. All cases (nine eyes) that required surgical intervention for secondary glaucoma underwent secondary PKP (P < 0.001).Conclusion:Repeat DSAEK is feasible in up to two-third of cases of failed DSAEK. A PKP is required in one-third of cases, and various preoperative, intraoperative and postoperative factors are associated with unsuitability for repeat DSAEK.

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Intrascleral fibrin glue intraocular lens fixation combined with Descemet-stripping automated endothelial keratoplasty or penetrating keratoplasty

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 27 publications

References 25 publications

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Descemet stripping automated endothelial keratoplasty

Repeat keratoplasty in failed Descemet stripping automated endothelial keratoplasty

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