Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Abstract

Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

Era of Bloodless Surgery: Spotlights on Hemostasic Materials and Techniques

“…of fibrin sealant [33]. Since then, fibrin sealants, consist of 2 components that combine thrombin and fibrinogen, have been approved and used currently [34]. Fibrin sealants are useful in the patient who has been heparinized or who has coagulation impairment such as hemophilia or von Willebrand' s disease, and they don't promote inflammation of tissue [35][36][37].…”

Biopolímeros: aplicações farmacêutica e biomédica

“…Outra propriedade importante da fibrina é a biodegradabilidade determinada pela ação da plasmina, originária do plasminogênio, por ação do As propriedades bioquímicas e mecânicas apresentadas pela fibrina permitem sua aplicação em medicina e bioengenharia como selante 11,12 aprovado pelo Food and Drug Administration (FDA).…”

“…O selante de fibrina é um material constituído basicamente por dois componentes, fibrinogênio e trombina, que na presença de cálcio e do fator XIIIa, a trombina é capaz de converter fibrinogênio em fibrina insolúvel, que constitui a forma estável final do agente 12 …”

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“…200 scientific and clinical reports each year. 2 Consequently, it is obvious that the use of sealants in modern-day surgery is of interest for surgeons of various surgical specialties, with the main goal being an improvement in patient care.…”