Intrapulmonary Solitary Fibrous Tumor Diagnosed by Immunohistochemical and Genetic Approaches: Report of a Case

Abstract

Although solitary fibrous tumors (SFTs) of the pleura are not uncommon, intrapulmonary SFTs are extremely rare. A 72-year-old woman was admitted to our hospital for an investigation of an enlarging intrapulmonary tumor. Because a definitive diagnosis could not be readily established, a pulmonary wedge resection under video-assisted thoracic surgery was performed. Grossly, the tumor was white, well circumscribed, and separate from the pleural surface. Histologically, it consisted of spindle cells proliferating in a vague fascicular pattern, with many dilated capillaries, and intermingled glandular components. These findings suggested a differential diagnosis that included SFT and nonchondromatous pulmonary hamartoma. On immunohistochemical analysis, the spindle cells showed a strong positive reaction to the CD34 antigen. Interphase fluorescent in situ hybridization revealed an absence of HMGA-1 and -2 translocations. These results supported a diagnosis of SFT. A genetic approach may therefore be useful in the differentiation of SFT from nonchondromatous hamartoma.

Intrapulmonary solitary fibrous tumor with bronchial involvement: a rare case report in a child

“…The majority of the reported intrapulmonary cases have been treated with tumor resection. Complete surgical excision and obtaining a clear margin can prevent tumor recurrence [2,3,5,6].…”

Intrapulmonary Solitary Fibrous Tumor Masquerade Sigmoid Adenocarcinoma Metastasis

“…Several studies have reported positivity of tumor cells with CD34 antibody in almost 100% of cases, and with CD99 antibody in 70% of cases, whereas Bcl-2, SMA, and epithelial membrane antigen are positive in 20% to 35% of the cases. Vimentin is positive in 90% of the cases, but is considered nonspecific [7,8]. …”

Mesenchymal Tumors of the Lung

“…Subsequently, only a few additional case reports have been presented in the literature. [90][91][92][93][94] …”

“…7-48), whereas staining for keratin, actin, desmin, and S-100 protein is negative in the spindle cell component. In one of the reported cases, 93 the investigators performed genetic studies disclosing that the tumor was negative for HMGA1 and HMGA2 (high mobility group AT-hook 1 and 2) translocations. …”