Intraoperative assessment of reconstructed vessels in living-donor liver transplantation, using a novel fluorescence imaging technique

Abstract

Fluorescence imaging can clearly visualize the reconstructed hepatic artery and portal vein and demonstrate the production of bile by a transplanted liver graft. A combination of IDUS and the new system can guarantee the patency of the reconstructed vessels.

The potential for bio-optical imaging of biomaterial-associated infection in vivo

“…Bioluminescent and fluorescent imaging facilities have rapidly found their way into animal research on cancer [17,18], atherosclerosis [19], neurological diseases like Alzheimer [20] and infectious diseases [21][22][23][24]. Human evaluations of near-infrared vascular imaging and tumour imaging and lymph node detection have been reported by several groups [25][26][27]. Considering the rapid introduction of bio-optical imaging in various biomedical disciplines and its recent clinical successes, it is anticipated that bio-optical imaging will become an important technique in the study of BAI and the development of clinically effective antimicrobial coatings, according to the pathway outlined in Fig.…”

Optical and Opto-Acoustic Interventional Imaging

“…159 In addition to fluorescein, indocyanine green (ICG) 168 has also been considered as an alternative organic dye for optical imaging applications operating in the near-infrared. Since operation in the near-infrared allows imaging deeper than in the visible, ICG has been more recently employed in several interventional applications, for example for sentinel lymph node (SLN) identification in breast, 202 gastric, 101 cervical 34 and vulvar 33 cancer, for angiography during reconstructive surgery, 39,73,113,185,210 skin flap perfusion, 78 lymphatic drainage mapping 1,172 and for imaging of glioma 70 and liver cancer 66,89 and metastases. 203 Results obtained with ICG during a hepatectomy procedure can be seen in Fig.…”

High-sensitivity detection of breast tumorsin vivoby use of a pH-sensitive near-infrared fluorescence probe

“…In the future, the pH-responsive dye CypHer5E, conjugated to tumor-specific ligands, may be applied for the fast and sensitive detection of weak signals, deriving for instance from small metastatic lesions in vivo. Although the NIR fluorophore Indocyanine Green (ICG) is currently the only dye approved by the US Food and Drug Administration for use in patients, 49 pH-sensitive targeted probes such as CypHer5E conjugated to antibodies specifically binding to tumor-associated antigens like HER2 and other targeted probes with a sensor function are expected to have a bright future in medical imaging and implementation in clinical applications to detect tumor lesions in vivo or to monitor therapy efficiency in cancer patients over time with high sensitivity.…”