Optical and Opto-Acoustic Interventional Imaging

Sarantopoulos, Athanasios; Bézière, Nicolas; Ntziachristos, Vasilis

doi:10.1007/s10439-011-0501-4

Cited by 12 publications

(20 citation statements)

References 222 publications

(208 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27,28 Likewise, the emergence of diverse fluorescence imaging strategies to enhance endoscopic detection, such as esophageal imaging or in colonoscopy, 29,30 can similarly benefit for strategies that enhance the sensitivity of fluorescence imaging. We demonstrated that the application of this algorithm can lead to real-time operation, which is an important feature for practical integration of this approach into the operating room.…”

Section: Discussionmentioning

confidence: 99%

Video-rate optical flow corrected intraoperative functional fluorescence imaging

et al. 2014

Self Cite

View full text Add to dashboard Cite

Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts. However, fast imaging implementations also limit the sensitivity of fluorescence detection. To improve on detection sensitivity in video rate fluorescence imaging, we considered herein an optical flow technique applied to texture-rich color images. This allows the effective accumulation of fluorescence signals over longer, virtual exposure times. The proposed correction scheme is shown to improve signal-to-noise ratios both in phantom experiments and in vivo tissue imaging.

show abstract

Section: Discussionmentioning

confidence: 99%

Video-rate optical flow corrected intraoperative functional fluorescence imaging

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…If the particles are travelling faster than the speed of light in that medium, the transferred energy is released, through relaxation, as light 33 Radionuclides introduced to the patient emit γ radiation. γ photons have sufficient energy to pass relatively unimpeded through tissue to be detected by an external camera 34 Type of information Presence of a fluorophore or specific tissue properties in a certain area 6,9 Differences in optical absorption inside tissue are visualized 11 Functional images based on the distribution of an externally administered particle-emitting radiotracer 35 Quantitative functional images based on the distribution of an externally administered γ-emitting radiotracer 36 Anatomical information No; however, autofluorescence provides information about tissue properties 9…”

Section: Multispectral Optoacoustic Tomographymentioning

confidence: 99%

“…Yes, by strong endogenous absorbers like blood and melanin 11 Real time, in the millisecond range, and related to the surgical field 3,4 Image generation in real time. Possible to perform advanced analysis after the process Several minutes 33,34 Depends on amount of activity versus signal to noise ratio.…”

Section: Multispectral Optoacoustic Tomographymentioning

confidence: 99%

“…Yes, depending on technique 41 Yes 21,43 , tomographic images of biological tissue are generated (morphology) 11,41,46 No, it is based on tissue-specific molecular signatures 47 2D/3D 2D, 3D is possible by using stacked images or measuring at a different depth 2D and 3D depending on detector used 44 A spectrum is generated, not an image 15,48,49 Need for contrast agent No, it is a label-free method as it uses intrinsic properties of molecules 42 No, depends on optical scattering and reflectance of tissue to generate contrast 41,44,46 No, it is a label-free technique 15,48,49 Cost (machine and facility) € € €€ 47 Acquisition cost € € € Time (acquisition and reconstruction) Short (1-10 min) 41 . Spontaneous Raman scattering: acquisition time 0⋅05 s for a single high-quality spectrum.…”

Section: Anatomical Informationmentioning

confidence: 99%

“…Real time 11,44 ; an image can be taken every 5 s 21,43 . Total acquisition time up to 5 min 41,46 A couple of seconds (< 3 s) 15,47 .…”

Section: Anatomical Informationmentioning

confidence: 99%

See 2 more Smart Citations

Modalities for image- and molecular-guided cancer surgery

Stammes

Bugby

Porta

et al. 2018

British Journal of Surgery

View full text Add to dashboard Cite

Background: Surgery is the cornerstone of treatment for many solid tumours. A wide variety of imaging modalities are available before surgery for staging, although surgeons still rely primarily on visual and haptic cues in the operating environment. Image and molecular guidance might improve the adequacy of resection through enhanced tumour definition and detection of aberrant deposits. Intraoperative modalities available for image-and molecular-guided cancer surgery are reviewed here.Methods: Intraoperative cancer detection techniques were identified through a systematic literature search, with selection of peer-reviewed publications from January 2012 to January 2017. Modalities were reviewed, described and compared according to 25 predefined characteristics. To summarize the data in a comparable way, a three-point rating scale was applied to quantitative characteristics. Results:The search identified ten image-and molecular-guided surgery techniques, which can be divided into four groups: conventional, optical, nuclear and endogenous reflectance modalities. Conventional techniques are the most well known imaging modalities, but unfortunately have the drawback of a defined resolution and long acquisition time. Optical imaging is a real-time modality; however, the penetration depth is limited. Nuclear modalities have excellent penetration depth, but their intraoperative use is limited by the use of radioactivity. Endogenous reflectance modalities provide high resolution, although with a narrow field of view. Conclusion:Each modality has its strengths and weaknesses; no single technique will be suitable for all surgical procedures. Strict selection of modalities per cancer type and surgical requirements is required as well as combining techniques to find the optimal balance.

show abstract