Intraocular pressure and systemic blood pressure after administration of vasoactive substances in hypertensive and normal rats

Funk, Richard; Rohen, Johannes W.; Skolasińska, K

doi:10.1007/bf02148890

Cited by 20 publications

(15 citation statements)

References 14 publications

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“…The technique we used to measure the IOP is the one used by Funk et al [6] in the adult rat, and can thus be considered to be reliable. However, the technical difficulties associated with the use of this method in the tiny eyes of the eleven-day-old rat are considerable and we were forced to discard approximately 40% of our measurements as unreliable.…”

Section: Discussionmentioning

confidence: 99%

Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate

et al. 1991

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The effects of timolol maleate on intraocular pressure (IOP) and the severity of retinopathy induced by exposure to 80% oxygen were studied in newborn Wistar rats. One drop of timolol maleate (0.25%) instilled in each eye twice a day for the first ten days of life substantially reduced intraocular pressure without significantly modifying arterial pressure. Forty percent of the ratlings treated in this way failed to develop oxygen-induced retinopathy (OIR) after exposure to 80% oxygen for the first five days of life; in the other 60% OIR was less severe than that seen in an identically oxygenated group that did not receive timolol. The authors hypothesize that the pharmacologically induced reduction in IOP may have attenuated the effects of the high concentrations of oxygen on the immature retinal vessels by improving the ocular perfusion pressure. The possibility that timolol maleate also exerts a direct action on the caliber of these vessels cannot be excluded.

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Section: Discussionmentioning

confidence: 99%

Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate

et al. 1991

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“…8 We could find only one other study of IOP in chronic experimental hypertension. Funk et al 9 reported that IOP is decreased in strokeprone spontaneously hypertensive rats compared with that in normotensive Wistar-Kyoto controls and found a negative correlation between IOP and blood pressure in hypertensive rats. They suggested that a reduced compliance of intraocular vessels may have been responsible.…”

Section: Discussionmentioning

confidence: 99%

Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.

Bell¹,

Hollingsworth²,

Overbeck³

1987

Hypertension

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SUMMARY We examined the relationship of intraocular pressure and the development of onekidney, one wrapped (perinephritic) hypertension in the dog. Conscious femoral arterial pressure (direct arterial puncture) and intraocular pressure (Schiotz tonometer) were measured weekly before and after the surgical induction of hypertension in 11 healthy male mongrel dogs and before and after unilateral nephrectomy in 15 normotensive control dogs. Preoperative mean arterial pressure (102 ± 5 vs 99 ± 8 [SD] mm Hg, hypertensive vs control dogs) and intraocular pressure (18.1 ± 2.5 ys 17.7 ±2.1 mm Hg, hypertensive vs control dogs) were similar in both groups. In normotensive control dogs, mean arterial pressure and intraocular pressure averaged over the postoperative period (4-8 weeks) did not differ significantly from preoperative values. In contrast, during the same period arterial pressure significantly increased and intraocular pressure significantly decreased in hypertensive dogs (arterial pressure, 163 ± 8 mm Hg; intraocular pressure, 11.9 ± 4.0 mm Hg; p < 0.001 for both values compared with corresponding values in control dogs). Intraocular pressure was inversely related to arterial pressure in hypertensive dogs (r = 0.56, p<0.01). These observations indicate that intraocular pressure decreases with the development of canine one-kidney, one wrapped hypertension. The mechanism of this decrease may be related to abnormalities in Na+,K + -adenosine triphosphatase activity found in this form of hypertension. (Hypertension 10: 152-156, 1987) KEY WORDS * blood pressure • aqueous humor • Na+,K+-adenosine triphosphatase T HERE is evidence for a circulating inhibitor of the Na + ,K + pump in dogs with chronic onekidney, one wrapped (1K1W; perinephritic) hypertension.1 -2 Because inhibition of Na + ,K + -adenosine triphosphatase (Na + ,K + -ATPase) has been associated with decreases in intraocular pressure, 34 we measured intraocular pressure during the development of perinephritic hypertension in dogs. Materials and MethodsOur techniques were similar to those we have used previously.15 Briefly, we trained healthy male mongrel pound dogs weighing between 20 and 32 kg and maintained on standard dog chow and water ad libitum

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“…4,5 However, the potential effects of these drugs on IOP and ocular blood flow, especially ciliary blood flow, should be discussed. The literature reports no significant effect of angiotensin II on IOP, either by topical application 31,32 or intravitreous injection.…”

Section: Experimental Study In Pigsmentioning

confidence: 99%

Effect of Acute Increase in Blood Pressure on Intraocular Pressure in Pigs and Humans

Castejon

Chiquet

Savy

et al. 2010

Invest. Ophthalmol. Vis. Sci.

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Intraocular pressure and systemic blood pressure after administration of vasoactive substances in hypertensive and normal rats

Cited by 20 publications

References 14 publications

Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate

Reduced severity of oxygen-induced retinopathy in the newborn rat after topical administration of timolol maleate

Decreased intraocular pressure in dogs with one-kidney, one wrapped hypertension.

Effect of Acute Increase in Blood Pressure on Intraocular Pressure in Pigs and Humans

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