Intranuclear inclusions in neurons of the cat primary olfactory system

Willey, T. Joe; Schultz, Robert L.

doi:10.1016/0006-8993(71)90415-x

Cited by 39 publications

(3 citation statements)

References 25 publications

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“…Although others have noted the predilection of neurons of the olfactory system for intranuclear inclusions (Siegesmund et al, 1964;Willey and Schultz, 19711, our results show quantitatively that in the piriform cortex lattice-containing nuclei are concentrated in the superficial third of layer 11. Our data may be compared with the qualitative observations on this cortical region in the cat by Willey and Schultz (1971), who stated that nuclei with rodlike or latticelike inclusions were frequently seen near the olfactory peduncle in cells deep to the axons of the LOT. In the rat, cells in this location merge at more caudal levels with layer I1 of PCx.…”

Section: Discussionmentioning

confidence: 53%

“…These structures are similar to those described by others (Feldman and Peters, 1972;Seite et al, 1971aSeite et al, ,b, 1979. No microtubules or other structures (Seite et al, 1979) were observed in close association with the lattices, but there was often a chromatin-sparse zone surrounding individual lattices (Willey and Schultz, 1971). Multiple lattice profiles in a single nucleus were seen in only one cell, and in that one case, these profiles apparently represented multiple transsections through a single con-cave lattice.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of inclusions within neuronal nuclei has been recognized in light microscopic preparations for almost a century (Mann, 1894), but the details of the organization of these structures have not been appreciated until more recent electron microscopic studies. Such nuclear inclusions have been noted in both normal (Siegesmund et al, 1964;Chandler and Willis, 1966;Seite et al, 1971a;Willey and Schultz, 1971;Feldman and Peters, 1972) and pathological (Field et al, 1969;Toper et al, 1980) material. In general, these inclusions consist of microfilaments which are organized into either bundles or lattices (Seite et al, 1971a(Seite et al, , 1979Feldman and Peters, 19721, and both kinds are reported to increase in old animals (Field and Peat, 1971;Feldman and Peters, 1972;Johnson and Miquel, 1974;Johnson et al, 1975;Vaughan andVincent, 1979, Brion et al, 1982).…”

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confidence: 91%

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Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II

1984

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Intranuclear inclusions have been observed in layer II neurons of rat piriform cortex. These inclusions have the form of a filamentous lattice and resemble those described by others previously. The frequency of lattice-containing nuclei shows a significant fourfold increase over a period of 3-33 months of age, with the largest increase occurring after 18 months. The incidence of these inclusions is highest in the superficial third of layer II and is significantly greater than what would be expected from the distribution of all neuronal nuclei in layer II. The presence of intranuclear lattices may be related to the high level of electrical activity in piriform cortex, and their increase with age may reflect a long-term cumulative effect of this activity.

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Section: Discussionmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 91%

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Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II

1984

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Polymyositis With Intranuclear Inclusions

Schochet¹,

McCormick²

1973

Arch Neurol

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Choroid plexus carcinoma: Report of a case with lmmunohistochemical and ultrastructural observations

McComb

Burger

1983

Cancer

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A choroid plexus carcinoma from the lateral ventricle of a ten‐month‐old boy was examined by light and electron microscopy. The neoplasm exhibited papillary and solid areas, invasion of adjacent brain, cytologic anaplasia, and necrosis. Intra‐ and extracellular PAS positive droplets were present, but no pigment was observed. No glial fibrillary acidic protein was detected within neoplastic cells. Ultrastructural examination revealed irregular nuclei with large nucleoli and occasional intranuclear filamentous rods. Cytoplasmic organelles included a moderate number of free ribosomes, rough endoplasmic reticulum, Golgi complexes, and microtubules. In some areas, numerous mitochondria filled the cytoplasm. Surface specializations included zonulae adherentes, microvilli, and clusters of cilia with a 9 + 0 microtubular pattern. Clusters of basal bodies with prominent basal feet and striated rootlets were present within the cytoplasm. Normal choroid plexus from this patient also had 9 + 0 cilia. In contrast, choroid plexus papillomas from two other infants had cilia with a 9 + 2 pattern. These observations demonstrate that both differentiated and anaplastic choroid plexus neoplasms have the potential to form cilia, and that the microtubular structure of such cilia may deviate from the usual 9 + 2 pattern.

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Intranuclear inclusions in neurons of the cat primary olfactory system

Cited by 39 publications

References 25 publications

Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II

Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II

Polymyositis With Intranuclear Inclusions

Choroid plexus carcinoma: Report of a case with lmmunohistochemical and ultrastructural observations

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