Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II

Curcio, Christine A.; McNelly, Nancy A.; Hinds, James W.

doi:10.1002/ar.1092100413

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…• 34000 plastic tissue. Other studies have concluded that intranuclear rods are a sign of increased cellular activity, and may reflect the overall electrical activity of neurons (Curcio et al 1984;Feldman and Peters 1972;Seite et al 1977). There are also suggestions that the rods are related to the aging of neurons (Miquel et al 1983).…”

Section: Cell Nucleusmentioning

confidence: 98%

“…Intranuclear rods have been found in neurons in different regions of the nervous system without any obvious connection to a distinct cell type (Curcio et al 1984;Siegesmund et al 1964). They have also been found in the cells of non-neural tissues and in poorly-differentiated neoplasm cells (Fukuda et al 1987;Ghadially 1982;Payne and Nagle 1983).…”

Section: Cell Nucleusmentioning

confidence: 99%

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Postnatal development of the light and electron microscopic features of basket cells in the hippocampal dentate gyrus of the rat

Seress

Ribak

1990

Anat Embryol

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Light and electron microscopic preparations were used to analyze the postnatal development of the basket cells of the rat dentate gyrus. The basket cells, located at the hilar border, were recognized in 2-day-old rats in Golgi preparations, where they displayed immature dendrites and a small axon arbor in the granule cell layer. At 5 days, the basket cells were found to have a large perikaryal cytoplasm, a round nucleus, an axon that forms symmetric synapses with granule cells, and dendrites and somata that are contacted by other axon terminals. The 10-day basket cells display more mature features, such as Nissl bodies and well-developed Golgi complexes. The basket cells from 16-day-old rats are mature in terms of their ultrastructural features, in that the nuclei are highly indented and display intranuclear rods or sheets, the perikaryal cytoplasm is packed with organelles, and the axon has developed an extensive arborization with the somata and dendrites of granule cells at the border with the molecular layer. This arborization will continue to expand as more granule cells are generated and added to the hilar border. These data correlate well with the immunocytochemical and biochemical development of GABAergic neurons in the dentate gyrus. Furthermore, the maturation of the structure of basket cells appears to precede the appearance of adult-like electrical activity in the hippocampus.

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Section: Cell Nucleusmentioning

confidence: 98%

Section: Cell Nucleusmentioning

confidence: 99%

Postnatal development of the light and electron microscopic features of basket cells in the hippocampal dentate gyrus of the rat

Seress

Ribak

1990

Anat Embryol

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Roncoroni Re‐Visited: The Neuronal Intranuclear Rodlet Comes of Age

Woulfe,

Munoz

2024

J of Comparative Neurology

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Despite myriad technological advances in neuroscience, the nervous system harbors morphological phenomena that continue to defy explanation. First described by the classical microscopists, including Santiago Ramon y Cajal, at the end of the 19th century, the neuronal intranuclear rodlet (INR) has mystified neurohistologists and microscopists for centuries. In this review article, we will provide an overview of the discovery of the INR as well as the subsequent attempts to elucidate its nature and functional significance. We outline our own studies of this structure over the past three decades, focusing on its elusive nature, its interactions with other nuclear organelles, and on disease‐related quantitative changes in Alzheimer's disease. We then describe our somewhat serendipitous discovery that these structures are filamentous aggregates of the nucleotide‐synthesizing metabolic enzyme inosine monophosphate dehydrogenase. The filamentation of metabolic enzymes to form mesoscale cellular structures called “rods and rings” or “cytoophidia” (Greek for “cellular snakes”) is a recently described phenomenon that remains to be systematically investigated in the nervous system. Thus, this review provides an intriguing historical juxtaposition in neuroscience, inculcating the neuronal INR, once a mere morphological curiosity, into one of the most rapidly evolving fields in contemporary cell biology.

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Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epithelium

Curcio

McNelly

Hinds

1985

J of Comparative Neurology

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Previous studies have quantified growth and atrophy of the olfactory bulb and olfactory epithelium of the Sprague-Dawley rat from maturity to senescence. Major events occurring in these structures include changes in the volume of mitral cells and changes in the number of septal olfactory receptors. These effects are large, consist of a growth phase followed by atrophy, and are temporally related in that events in the olfactory epithelium precede those in the mitral cells. A hypothesis of aging based on transneuronal effects would predict that these changes would be similarly transmitted to the next synaptic station in the olfactory pathway. Therefore, cells and synapses of the piriform cortex were studied in rats 3, 12, 18, 24, 27, 30, and 33 months of age. Alternate Vibratome sections through brains perfused with mixed aldehydes were processed for light and electron microscopy. No significant age effects were found for the volumes of cortical laminae Ia and Ib. Both numerical and surface density of synaptic apposition zones in layer Ia, formed primarily by mitral cell axons, were stable with age. A modest (18%) but significant decline in the proportion of layer Ia occupied by dendrites and spines was mirrored by an increase in the proportion of glial processes; no change in the proportion of axons and terminals was observed. Neither nuclear volume, nor soma volume, nor numerical density of layer II neurons changed with age. Thus, contacts made in the piriform cortex by mitral cell axons remain relatively stable in senescence, despite the marked volumetric changes in the mitral cell somata, changes which were confirmed again in this study. Age-related dendritic regression in layer II neurons may be attributable to functional deafferentation subsequent to reduced receptor input to mitral cells.

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Intranuclear inclusions in rat piriform cortex: Increase with age and preferential location within superficial layer II

Cited by 6 publications

References 28 publications

Postnatal development of the light and electron microscopic features of basket cells in the hippocampal dentate gyrus of the rat

Postnatal development of the light and electron microscopic features of basket cells in the hippocampal dentate gyrus of the rat

Roncoroni Re‐Visited: The Neuronal Intranuclear Rodlet Comes of Age

Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epithelium

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