Polymyositis With Intranuclear Inclusions

Schochet, Sydney S.; McCormick, William F.

doi:10.1001/archneur.1973.00490220088017

Cited by 15 publications

(2 citation statements)

References 20 publications

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“…1971 faßten Yunis und Samaha (27) erstmals eine eigene sowie 3 aus der Literatur bereits bekannte (1,4,6) Beobachtungen einer ungewöhnlichen neuromuskulären Erkrankung als klinisch-pathologische Einheit zusammen und prägten daftir die Bezeichnung ,,Einschlußkörpermyositis" . In der Folgezeit wurden weitere Fälle (3,5,9,11,14,20,22,23,25) dieses nach heutiger Kenntnis seltenen, vorwiegend elektronenmikroskopisch definierten, jedoch auch klinisch relativ einheitlichen Krankheitsbildes mitgeteilt.…”

Section: Introductionunclassified

“…,,Einschlußkörpermyositis" , die vorwiegend Männer im mittleren Lebensalter befällt und bei der keine Heredität besteht, eine meist langsam progrediente, selten auch rezidivierende (23), distal und beinbetonte Muskelschwäche und Atrophie. Ein generalisierter Muskelbefall (9,11,20), eine hauptsächliche Manifestation in der proximalen Skelettmuskulatur (11,20,23,25) oder eine Mitbeteiligung der von den Hirnnerven innervierten Muskelgruppen (l1, 20, 23) kommen seltener vor. Diskrete Sensibilitätsstörungen wurden beschrieben (3).…”

Section: Introductionunclassified

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Klinik und Morphologie der sog. ,,Einschlußkörpermyositis"

Lisson¹,

Pongratz²,

Hübner³

et al. 1980

Fortschr Neurol Psychiatr

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A non-hereditary slowly progressive neuromuscular disease occuring in a 39-year-old male, consisting of an asymmetrical wasting of the muscles of the shanks, is reported. Neither clinical nor electromyographic criteria can safely distinguish whether a primary neurogenic or a primary myogenic process is causally involved. The initial rise in serum CPK-activity indicates a myopathic origin. The lightmicroscopic aspect of the muscle-biopsy shows a muscular atrophy which resembles a primary neurogenic pattern with grouped clusters of atrophic fibers as well as a myopathic or rather myositic tissue-pattern with randomly scattered atrophic fibers. In addition there are numerous vacuoles which are equivalent to concentric lamellae of dense material in electronmicroscopy. Numerous fibrillary inclusions as well in the cytoplasm as in the cell-nucleus correspond to typical alterations in the so-called "inclusion body myositis". The disease is critically discussed as a nosological entity among neuromuscular disorders.

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Section: Introductionunclassified

Klinik und Morphologie der sog. ,,Einschlußkörpermyositis"

Lisson¹,

Pongratz²,

Hübner³

et al. 1980

Fortschr Neurol Psychiatr

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Intranuclear rod-shaped actin filament bundles in poorly differentiated axillary adenosquamous cell carcinoma

Fukuda

Uchiyama

Masuda

et al. 1987

Cancer

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An axillary cystic poorly differentiated adenosquamous cell carcinoma was studied by electron microscopy and immunohistochemistry for keratin, vimentin, desmin, and actin. Many tumor cells had rod-shaped intranuclear fibrillary inclusions which consisted of 60 A microfilaments. These intranuclear inclusions reacted with antiactin antibody and were considered to be F-actin bundles. The cells having intranuclear inclusions were frequently found in areas close to the cystic space, and inclusions of tumor cells close to the cyst were thicker. However, mitotic figures were predominantly found in the periphery of the tumor. Intranuclear actin is known to be mainly soluble G-actin, and one of its important functions is reported to be the chromosome condensation in mitosis. It is speculated that the cells having intranuclear fibrillary inclusions of actin have impairment of mitosis.

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Subacute skeletal myopathy induced by 2,4‐dichlorophenoxyacetate in rats and guinea pigs

1978

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Rats and guinea pigs were injected with 2,4-dichlorophenoxyacetate (2,4-D) in amounts sufficient to keep them myotonic for over 12 hr daily. The biceps brachii muscles were studied by histochemistry, epoxy resin histology, and electron microscopy after one to five days. Changes observed include proliferation of the longitudinal component of the sarcoplasmic reticulum, production of new myofilaments on the periphery of cells and in nuclei, activation of satellite cells, accumulation of lipid droplets, myofibrillar damage with Z-disc streaming, necrosis, and regeneration. The action mehanisms of 2,4-D are not well understood. Some of the phenomena observed could be classified as proliferative and may be analogous to the auxin action of 2,4-D in plants. The production of intranuclear filaments is probably related to the diffusion of newly formed cytoplasmic proteins into nuclei.

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Polymyositis With Intranuclear Inclusions

Cited by 15 publications

References 20 publications

Klinik und Morphologie der sog. ,,Einschlußkörpermyositis"

Klinik und Morphologie der sog. ,,Einschlußkörpermyositis"

Intranuclear rod-shaped actin filament bundles in poorly differentiated axillary adenosquamous cell carcinoma

Subacute skeletal myopathy induced by 2,4‐dichlorophenoxyacetate in rats and guinea pigs

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