Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice

Abstract

Lung cancer is the most lethal cancer in the world. About 80% of lung cancer deaths are linked to tobacco use. As a complement to tobacco control, efficient chemoprevention strategies are needed to tackle lung cancer epidemic. Resveratrol is one of the most studied natural products, notably for its cancer chemoprevention properties. However, its low oral bioavailability has often limited the translation of in vitro activities to in vivo effects. While oral administration of resveratrol effectively inhibited colorectal carcinogenesis, it failed to protect mice from chemically-induced lung carcinogenesis. Therefore, non-invasive parenteral routes must be considered to bring resveratrol to the lungs. In the present study, intranasal administration of a concentrated formulation proved to be a valid method to expose the lungs to a sufficient amount of resveratrol. This formulation was administered three times a week for 25 weeks to A/J mice having 4-[methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanone-induced lung carcinogenesis. Resveratrol-treated mice showed a 27% decrease in tumour multiplicity, with smaller tumours, resulting in 45% decrease in tumour volume/mouse. In vitro investigations highlighted apoptosis as a potential mechanism of action. This study presents an effective way to overcome resveratrol low oral bioavailability, encouraging a reevaluation of its use in future clinical trials.

A Chitosan-PLGA based catechin hydrate nanoparticles used in targeting of lungs and cancer treatment

“…delivery of CAT. This is a very apparent observation via nose to lungs targeted potential ( Monteillier et al, 2018 , Dao et al, 2018 , Worth et al, 2000 , Jin et al, 2019 ).

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“…Now a drays, various research scientists are targeting the drugs via nose–to–lungs that showed different types of useful applications like avoid hepatic first pass metabolism and non-invasive route with easy to application of drugs ( Monteillier et al, 2018 , Dao et al, 2018 , Worth et al, 2000 , Jin et al, 2019 ). Therefore, these PLGA-NPs.…”

Health benefits of resveratrol administration

“…Monteillier and others (Monteillier et al, 2018) showed that intranasal administration of 60 mg/kg resveratrol to mice with induced lung cancer caused a notable decrease in the tumor multiplicity and volume via enhanced apoptosis. Moreover, treating gastric cancer cells with resveratrol elevated the levels of pro-apoptotic proteins such as Bax, while the levels of anti-apoptotic proteins such as Bcl-2 were decreased compared to untreated controls .…”

Cancer Chemoprevention Using Nanotechnology-Based Approaches

“…A 25-day in vivo study in A/J mice lung carcinogenesis model demonstrated 27% reduction in tumor multiplicity with 45% lower tumor volume confirming the efficacy of the developed formulation. Such a formulation approach is anticipated to enhance the drug bioavailability and hence has great potential in future clinical studies (Monteillier et al, 2018). In another study, lipid nanoparticles (NPs) of three chemopreventive drugs N-acetyl-L-cysteine, phenethyl isothiocyanate, and resveratrol were developed and their chemopreventive potential was assessed in bronchial epithelial cells.…”