Cancer Chemoprevention Using Nanotechnology-Based Approaches

Abstract

Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances in recent years. However, the incidence rate of cancer is still very high. Almost 40% of women and men are diagnosed with cancer during their lifetime. Such high incidence has not only resulted in high mortality but also severely compromised patient lifestyles, and added a great socioeconomic burden. In view of this, chemoprevention has gained wide attention as a method to reduce cancer incidence and its relapse after treatment. Among various stems of chemoprevention research, nanotechnology-based chemoprevention approaches have established their potential to offer better efficacy and safety. This review summarizes recent advances in nanotechnology-based chemoprevention strategies for various cancers with emphasis on lung and bronchial cancer, colorectal, pancreatic, and breast cancer and highlights the unmet needs in this developing field towards successful clinical translation.

Chemopreventive efficacy of salvianolic acid B phospholipid complex loaded nanoparticles against experimental oral carcinogenesis: implication of sustained drug release

“…Hence, we used the 4NQO-induced mouse oral carcinogenesis in this study. (23). Nanoparticle-mediated delivery is a promising approach to enhance bioavailability and increase the efficacy of several chemopreventive agents for OSCC (24)(25)(26)(27)(28).…”

Regularities of Cementite Decomposition in Hypereutectoid Steels

“…The results obtained can be used to create resource-saving processes and technologies for processing structural and tool materials using new nanocomposite lubricants and coatings in various conditions and states of metal systems, taking into account the recommendations of [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

The Benefits of Smart Nanoparticles in Dental Applications

“…As drug delivery systems, smart nanoparticles present superior properties, including a small size; a wider therapeutic window; the ability to overcome multiple drug resistance; multifunctionality; long circulation drugs; the ability to minimize off-target effects; a pH-triggered on/off switchable system; a superior efficacy; a decreased toxicity; improved pharmacokinetics; the feasibility of incorporation of both hydrophilic and hydrophobic active principles; controlled/sustained release; an enhanced permeability and retention; and the feasibility of variable routes of administration, including oral and parenteral administration and inhalation [ 31 , 32 , 33 , 34 ].…”