Intranasal administration of midazolam in blue-and-yellow macaws ( Ara araruana ): evaluation of sedative effects

Schäffer, Débora Ph; Raposo, Ana; Libório, Fernanda A.; Silva, Renata Mm; Araújo, Nayone Lima Lantyer Cordeiro de; Oriá, Arianne Pontes

doi:10.1111/vaa.12355

Cited by 11 publications

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“…Midazolam, a benzodiazepine sedative, has been used at the point of capture of wild birds to minimize stress and physical exertion and enhance animal welfare (Heatley et al 2015, Schäffer et al 2016, Le Net et al 2019). Midazolam has sedative, anxiolytic, and anticonvulsant effects in birds and has been used as an anesthetic premedication and to facilitate handling of birds in a zoological setting (Mans et al 2012, Araghi et al 2016).…”

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Effects of Midazolam on Corticosterone and Blood Gases in Spectacled Eiders Prior to Transmitter Implantation

et al. 2021

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Stress and physical exertion may affect the physiology and behavior of wildlife during and after capture, and consequently, survival following release. Such effects may reduce the quality and quantity of the data obtained from captured wildlife. We captured spectacled eiders (Somateria fischeri), a species listed as threatened under the United States Endangered Species Act, in western Alaska, USA, during spring 2018 for surgical implantation of satellite transmitters. We evaluated the efficacy of midazolam, a benzodiazepine sedative given at capture, to reduce stress and physical exertion. We dosed spectacled eiders with either midazolam (5 mg/ml, true x ¯ = 2.2 mg/kg intramuscular; n = 20) or saline (0.7 ml intramuscular; n = 20) at the point of capture. We assessed sedation level and collected blood samples upon arrival to the field surgery site and at anesthetic induction. We found that midazolam reduced mean corticosterone concentration by 29% and median lactate concentration by 30.3% at the mean arrival time (42 min post‐dosing) relative to the control group. These effects had abated by the mean induction time (99 min post‐dosing). Unexpectedly, blood pH was reduced in the midazolam treatment relative to controls at both arrival and induction, which likely resulted from sedative‐induced respiratory depression that was easily treated with intubation and mechanical ventilation, and administration of the reversal drug, flumazenil. Low blood pH was not associated with negative post‐surgical outcomes, as had been found in spectacled eiders with acidosis caused by anaerobic metabolism typical of physical exertion. Intramuscular injection of midazolam in the field effectively reduced stress and physical exertion in spectacled eiders prior to surgical implantation of transmitters. © 2021 The Wildlife Society.

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Effects of Midazolam on Corticosterone and Blood Gases in Spectacled Eiders Prior to Transmitter Implantation

et al. 2021

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“…O escore de sedação adotado neste estudo foi baseado no utilizado para avaliar o comportamento de araras canindé (Ara ararauna) sedadas com midazolam (SCHÄFFERA et al, 2016). A adaptação para este trabalho incluiu o movimento de bicos e garras na avaliação.…”

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>b<Avaliação do débito cardíaco de rapinantes, por meio de ecocardiografia, durante a sedação com dexmedetomidina e após a administração do antagonista atipamezole>/b<

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AGRADECIMENTOSÀ Deus pelo amor, proteção, por guiar e me dar tantas oportunidades.Ao São Benedito por nunca deixar de ouvir minhas orações.À minha família por torcer sempre por mim.À minha orientadora Prof.ª Denise Tabacchi Fantoni por acreditar tanto no meu trabalho e me guiar nessa jornada.Aos colegas de pós-graduação por dividirem comigo os piores e melhores momentos, por toda ajuda, colaboração e amizade.A todos os veterinários que colaboraram com a produção deste trabalho, por me fazerem lembrar que cruzei meu caminho com pessoas incríveis desde que vim para São Paulo."As aves de rapina despertam a admiração do homem desde tempos remotos. São aves emblemáticas, frequentemente representadas em brasões de famílias nobres, reinos antigos, cidades e bandeiras de países modernos. Muitas espécies de águias, falcões e corujas possuem vários papéis simbólicos na cultura de diferentes povos, representando atributos como a força, coragem, independência, sabedoria e filosofia (MENQ, 2017). RESUMO ENUMO, S. N. Avaliação do débito cardíaco de rapinantes, por meio de ecocardiografia, durante a sedação com dexmedetomidina e após a administração do antagonista atipamezole. 2022. 63 f. Dissertação (Mestrado em Ciências) -

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Mans

2021

Exotic Animal Emergency and Critical Care Medicine

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Intranasal administration of midazolam in blue-and-yellow macaws ( Ara araruana ): evaluation of sedative effects

Cited by 11 publications

References 5 publications

Effects of Midazolam on Corticosterone and Blood Gases in Spectacled Eiders Prior to Transmitter Implantation

Effects of Midazolam on Corticosterone and Blood Gases in Spectacled Eiders Prior to Transmitter Implantation

>b<Avaliação do débito cardíaco de rapinantes, por meio de ecocardiografia, durante a sedação com dexmedetomidina e após a administração do antagonista atipamezole>/b<

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