Intramuscular adipose tissue at level Th12 is associated with survival in COVID‐19

Viddeleer, Alain R.; Raaphorst, Joost; Min, Minoesch; Beenen, Ludo F. M.; Scheerder, Maeke J.; Bruin, Sanne de; Schuurmans, Alex; Koning, Rutger; Agtmael, Michiel A. van; Algera, Anne Geke; Baarle, Frank van; Bax, Diane; Beudel, Martijn; Bogaard, Harm Jan; Bomers, Marije; Bonta, Peter I.; Bos, Lieuwe; Botta, Michela; Brabander, Justin de; Bree, Godelieve de; Bugiani, Marianna; Bulle, Esther; Chouchane, Osoul; Cloherty, Alex; Dongelmans, Dave A.; Elbers, Paul; Fleuren, Lucas M.; Geerlings, Suzanne E.; Geerts, Bart F.; Geijtenbeek, T.B.H.; Girbes, Armand R.J.; Goorhuis, Abraham; Grobusch, Martin P.; Hafkamp, Florianne; Hagens, Laura A.; Hamann, Jörg; Harris, Vanessa; Hemke, Robert; Hermans, Sabine; Heunks, Leo; Hollmann, Markus W.; Horn, Janneke; Hovius, Joppe W.; Jong, Menno D. de; Mourik, Niels van; Nossent, Esther J.; Nellen, Jeaninne; Paulus, Frederique; Reijnders, Tom D.Y.; Peters, Edgar J.G.; Poll, Tom van der; Preckel, Bennedikt; Prins, Jan M.; Schinkel, Michiel; Schultz, Marcus J.; Sigaloff, Kim C.E.; Smit, Marry R.; Stijnis, Cornelis; Stilma, Willemke; Teunissen, Charlotte E.; Thoral, Patrick; Tsonas, Anissa M.; Valk, Marc van der; Veelo, Denise P.; Vries, Heder de; Vugt, Michèle van; Wouters, Dorien; Zwinderman, Aeilko H.; Brouwer, Matthijs C.; Wiersinga, W. Joost; Vlaar, Alexander P.J.; Beek, D. van der

doi:10.1002/jcsm.12696

Cited by 14 publications

(29 citation statements)

References 15 publications

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“…After reading the full texts, 21 studies were removed for not addressing the association between skeletal muscle status and COVID-19 infection severity ( 17 ) or for having evaluated outcomes exclusively by questionnaires; or for assessing pediatric populations. Seven ( 18 , 20 , 26 – 30 ) studies thus remained and were included in this systematic review ( Figure 1 ) ( 22 ). The main characteristics of these selected studies are described in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Yi et al ( 30 ) and Yang et al ( 29 ) CT analyses explored T12, associating COVID-19 severity with body composition (Severe 28.58 cm 2 /m 2 ± 15.31 and 34.61 cm 2 /m 2 ± 7.42; non-severe 26.4 cm 2 /m 2 ± 18.6 and 36.95 cm 2 /m 2 ± 6.25, respectively). Viddeleer et al ( 20 ) CT analysis was based on images at L3 level (severe 35.7 ± 9.5; non-severe 36.1 ± 9.1) and assessed the association between COVID-19 survival and body composition. The overall effect did not show statistical significance ( p = 0.28), despite the low heterogeneity ( I 2 = 12 %) [MD = 1.15; 95% CI: −3.21, −0.91; Z = 1.09; p = 0.28 ( Figure 3 )].…”

Section: Resultsmentioning

confidence: 99%

“…According to the results of NOS assessment, a low risk of bias was observed in the “selection” category, as well as “comparability” and “outcome” measured ( Figure 2 ). Some studies proved to be unrepresentative ( 20 , 26 , 27 ), as most recruited patients were critically ill ICU patients, coming from a highly heterogeneous population of patients with positive results for COVID-19. Data represented in the studies, in general, proved to be reliable, having been mainly obtained from patients' hospital records.…”

Section: Resultsmentioning

confidence: 99%

“…Skeletal muscle density can be determined, among other factors, by the amount of intramuscular fat. In fact, recently published studies have shown that the amount of intramuscular fat interferes with the prognosis of COVID-19 ( 20 , 29 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

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Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

et al. 2022

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COVID-19 caused by SARS-CoV-2 infection is a highly contagious disease affecting both the higher and lower portions of the respiratory tract. This disease reached over 265 million people and has been responsible for over 5.25 million deaths worldwide. Skeletal muscle quality and total mass seem to be predictive of COVID-19 outcome. This systematic review aimed at providing a critical analysis of the studies published so far reporting on skeletal muscle mass in patients with COVID-19, with the intent of examining the eventual association between muscle status and disease severity. A meta-analysis was performed to evaluate whether skeletal muscle quantity, quality and function were related to disease severity. Systematic reviews and meta-analyses were conducted according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and reported according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guide. From a total of 1,056 references found, 480 were selected after removing duplicates. Finally, only 7 met the specified inclusion criteria. The results of this meta-analysis showed that skeletal muscle quality, rather than quantity, was associated with COVID-19 severity, as confirmed by lower skeletal muscle density and lower handgrip strength in patients with severe disease. Muscle function assessment can thus be a valuable tool with prognostic value in COVID-19.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

et al. 2022

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“…CT scans can clearly discern fat from muscle because fat displays negative attenuation values, whereas attenuation for muscle is positive, and attenuation is sensitive to proton content per unit mass, which is high in adipose tissue [ 34 ]. The IMAT was also normalized by the squared patient height to obtain the IMAT index (IMATI, cm 2 /m 2 ), as previously described [ 35 ]. The SMI was used to define sarcopenia, with cut-off values at 52.4 cm 2 /m 2 for men and 38.5 cm 2 /m 2 for women, as previously described [ 36 , 37 , 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Association between CT-Based Preoperative Sarcopenia and Outcomes in Patients That Underwent Liver Resections

Martín

Maeder

Kobayashi

et al. 2022

Cancers

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This retrospective observational study aimed to evaluate whether preoperative sarcopenia, assessed by CT imaging, was associated with postoperative clinical outcomes and overall survival in patients that underwent liver resections. Patients operated on between January 2014 and February 2020 were included. The skeletal muscle index (SMI) was measured at the level of the third lumbar vertebra on preoperative CT scans. Preoperative sarcopenia was defined based on pre-established SMI cut-off values. The outcomes were postoperative morbidity, length of hospital stay (LOS), and overall survival. Among 355 patients, 212 (59.7%) had preoperative sarcopenia. Patients with sarcopenia were significantly older (63.5 years) and had significantly lower BMIs (23.9 kg/m2) than patients without sarcopenia (59.3 years, p < 0.01, and 27.7 kg/m2, p < 0.01, respectively). There was no difference in LOS (8 vs. 8 days, p = 0.75), and the major complication rates were comparable between the two groups (11.2% vs. 11.3%, p = 1.00). The median overall survival times were comparable between patients with sarcopenia and those without sarcopenia (15 vs. 16 months, p = 0.87). Based on CT assessment alone, preoperative sarcopenia appeared to have no impact on postoperative clinical outcomes or overall survival in patients that underwent liver resections. Future efforts should also consider muscle strength and physical performance, in addition to imaging, for preoperative risk stratification.

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Prognostic Role of the Pectoralis Musculature in Patients with COVID-19. A Multicenter Study

et al. 2023

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Intramuscular adipose tissue at level Th12 is associated with survival in COVID‐19

Cited by 14 publications

References 15 publications

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients

Association between CT-Based Preoperative Sarcopenia and Outcomes in Patients That Underwent Liver Resections

Prognostic Role of the Pectoralis Musculature in Patients with COVID-19. A Multicenter Study

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