Intralesional immunotherapy compared to cryotherapy in the treatment of warts

Khozeimeh, Fahime; Azad, Farahzad Jabbari; Oskouei, Yaghoub Mahboubi; Jafari, Mahdi; Tehranian, Shahrzad; Alizadehsani, Roohallah; Layegh, Pouran

doi:10.1111/ijd.13535

Cited by 82 publications

(65 citation statements)

References 18 publications

(37 reference statements)

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“…There are also reports of acute renal failure (Santos-Juanes et al, 2011) but the theoretical risk of inducing graft rejection has not been validated (Kovach & Stasko, 2005). Intralesional immunotherapy with Candida antigen has been shown to be superior to cryotherapy for the treatment of warts in immunocompetent patients (Khozeimeh et al, 2017). Candida immunotherapy is thought to induce a T cell mediated response and local production of cytokines IL-2 and IFN-gamma (Aldahan et al, 2016) (Reppucci, Dilorenzo, Abramson, & Steinberg, 1991).…”

Section: Discussionmentioning

confidence: 99%

Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients

Herold

Nielson

Longo

2019

Dermatologic Therapy

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Treatment of recalcitrant warts in solid organ transplant recipients (SOTR) can pose a therapeutic challenge for dermatologists. Successful treatment of recalcitrant warts can serve as secondary prevention for skin cancer in those with chronic immunosuppression. Given the heterogeneity of associated comorbid conditions in SOTR, clinical trials are difficult to conduct in this high‐risk population, therefore, our clinical practice is mostly driven by observed responses from studies in immunocompetent patients or from case reports of immunocompromised patients. The combination of systemic retinoids and candida immunotherapy likely provide the most effective treatment for recalcitrant warts in SOTR. However, many SOTR have chronic renal insufficiency and are not candidates for acitretin therapy. We provide two cases of recalcitrant warts in SOTR successfully treated with isotretinoin in the setting of impaired renal function.

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Section: Discussionmentioning

confidence: 99%

Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients

Herold

Nielson

Longo

2019

Dermatologic Therapy

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“…Pada Penelitian ini Dataset yang digunakan adalah dataset yang bersifat publik dan mengarah pada penelitian Khozeimeh [1] pengobatan kutil dengan metode cryotherapy, kemudian data-data di uji pada metode klasifikasi yang diterapkan aplikasi rapidminer. Sehingga dilanjutkan lagi dengan validasi data.…”

Section: Datasetunclassified

“…Penyebaran virus penyebab kutil bisa terjadi dengan mudah, contohnya hanya bersentuhan langsung dengan seseorang penderita kutil, tetapi tidak semua orang yang bersentuhan dengan virus hpv akan menimbulkan penyakit kutil. kekebalan tubuh (imunitas) masingmasing orang berbeda dan sangat berpengaruh dalam penularan penyakit ini, seseorang yang memiliki imunitas yang bermasalah akan rentan untuk terserang penyakit kutil [1].…”

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Komparasi Algoritma K-Nearest Neighbor dan Naiive Bayes Pada Pengobatan Penyakit Kutil Menggunakan Cryotheraphy

Brawijaya

Samudi

Widodo

2019

Juita

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Abstrak-Pengobatan penyakit kutil menggunakanCryotheraphy merupakan salah satu jenis pegobatan penyakit kutil yang direkomendasikan oleh beberapa pakar kesehatan. Metode yang digunakan dengan menggunakan nitrogen cair untuk pembekuan pada penyakit kutil. Dalam penelitian ini dilakukan komparasi pengujian model dengan menggunakan K-Nearest Neighbor dan Naiive Bayes untuk prediksi pengobatan penyakit kutil. Dalam proses pengujiannya, peneliti menggunakan aplikasi rapidminer untuk mengolah data dan melakukan pengujian. Hasil pengujian yang telah dilakukan menunjukkan pengujian menggunakan model K-Nearest Neighbor (K-NN) didapat nilai akurasi terbaik adalah 90,00% dengan nilai AUC sebesar 0,500 sedangkan hasil pengujian menggunakan model Naiive Bayes didapat nilai akurasi lebih kecil dibandingkan dengan model K-NN yaitu 86,67% dengan nilai AUC sebesar 0,932. Berdasarkan pengujian yang sudah dilakukan dapat disimpulkan bahwa model K-Nearest Neigbor memiliki tingkat akurasi lebih baik dibandingkan dengan model Naiive Bayes dalam prediksi pengobatan penyakit kutil menggunakan Cryotheraphy. Abstract-Treatment of warts using Cryotheraphy is a type of wart disease treatment recommended by several health experts. The method used is using liquid nitrogen for freezing in wart diseases. In this study a model test was performed using K-Nearest Neighbor and Naiive Bayes for research on the treatment of warts. In the testing process, researchers use the rapidminer application to process data and conduct testing. The results of tests that have been carried out on testing using the K-Nearest Neighbor (K-NN) model get the best test value that is 90.00% with an AUC value of 0.500 while the test results using the Naiive Bayes model get higher values with the K-NN model that is 86 , 67% with an AUC value of 0.932. Based on testing that has been done, it can be concluded that the K-Nearest Neigbor model has a better rating compared to the Naif Bayes model in predicting treatment of warts using Cryotheraphy.

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“…Siğil tedavisinde kriyoterapi ve immünoterapi tedavi yöntemleri en sık kullanılandandır. Literatürde bu iki tedavi yönteminin araştırıldığı birçok çalışma bulunmaktadır [16][17][18][19][20][21][22][23][24][25]. Fakat bu yöntemlerin tercih edilme ölçütleri tam olarak ispatlanamamıştır [15].…”

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“…Fakat bu yöntemlerin tercih edilme ölçütleri tam olarak ispatlanamamıştır [15]. Yakın tarihli bir çalışmada Khozeimeh ve arkadaşları [24] siğil tedavisinde kullanılan kriyoterapi ve immünoterapi yöntemlerinin tedavi yanıt verme süresi üzerindeki etkilerini makine öğrenmesine dayalı olarak tahmin etmeye çalışılmış ve ortalama %80 başarım elde edilmiştir. Uzun ve arkadaşları benzer bir başarım oranının en yakın 7 komşu sınıflandırıcı algoritması kullanılarak elde edilebileceğini göstermişlerdir [10].…”

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WEKA Yazılım Paketinin Siğil Tedavi Yöntemlerinin Başarısının Tahmininde Kullanımı

Uzun

İşler

Toksan

2019

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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ÖZET Son zamanlarda yaygın ve ayak taban siğili olan hastalara kriyoterapi ve immünoterapi tedavi yöntemleri uygulanmaya başlanmıştır. Bununla birlikte hangi tedavi yönteminin başarılı olacağına dair bir kanıt bulunmamaktadır. Bu çalışmada, bu iki yöntemin siğil tedavisinde başarılı olup olmayacağı lojistik regresyon ve karar ağacı algoritmaları kullanılarak tahmin edilmeye çalışılmıştır. Çalışmada açık erişime sahip olan UCI veri tabanındaki veriler kullanılarak WEKA yazılımı üzerinde algoritmalar koşturulmuştur. Sonuç olarak, seçilen siğil tedavi yönteminin başarısı karar ağacı sınıflandırıcısı ile %85,56 oranında doğru olarak tespit edilmiştir. ABSTRACTRecently, treatment methods of cryotherapy and immunotherapy have been got off the ground to the patients with common and plantar warts. On the other hand, there is no proof of which treatment method will be successful, yet. In this study, it is tried to predict whether these two methods succeed on wart treatment or not using the logistic regression and the decision tree algorithms. These algorithms were run on WEKA software using data sets that are freely available from UCI databases in this study. As a result, the success of the selected wart treatment method was predicted with the accuracy of 85.56% by using the decision tree algorithm.

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Intralesional immunotherapy compared to cryotherapy in the treatment of warts

Abstract: Intralesional immunotherapy is an effective treatment of warts. This method has a better therapeutic response, needs fewer sessions, and is capable of treating distant warts.

Cited by 82 publications

References 18 publications

Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients

Isotretinoin and candida immunotherapy for recalcitrant warts in solid organ transplant recipients

Komparasi Algoritma K-Nearest Neighbor dan Naiive Bayes Pada Pengobatan Penyakit Kutil Menggunakan Cryotheraphy

WEKA Yazılım Paketinin Siğil Tedavi Yöntemlerinin Başarısının Tahmininde Kullanımı

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