Intradiscal ozone therapy for lumbar disc herniation

Abstract

The rationale behind intradiscal O 2 -O 3 therapy is the pain elicited by the mechanical compression of the nerve root, which is associated with periganglionic and periradicular inflammation. This study aimed to determine the effect of intradiscal ozone injection on pain score and satisfaction of patients with low back pain (LBP) secondary to disc herniation. Patients with LBP diagnosed with disc herniation were enrolled in this clinical trial. After prepping and draping the area, intradiscal injection of ozone/oxygen mixture (10 ml, 25μg/ml) was performed under fluoroscopy guide (c-arm). Pain score and patient satisfaction were assessed prior to the injection (baseline) and 1, 3, 6, 12 and 24 months after the injection. Sixty three patients (24 males, 39 females) with mean age of 53.3 ±2.0 y enrolled in the study. The mean±standard deviation (SD) of pain score before intervention was 6.968 ±0.11. Pain score was reduced to 4.25±0.19 at 1 month, 4.33±0.20 at 3 months, 4.87 ±0.21 at 6 months and 5.22 ±0.20 at 24 months. According to the modified MacNab scale success of pain relief was as follows: excellent: 4 (6.3%),

Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats

“…To date, O 3 therapy has been widely used in oncology, gynecology, skin and mucosal infections, pain management, and other medical conditions because of its anti-inflammatory, antioxidant, antiseptic, and disinfectant properties [26, 27]. Furthermore, O 3 treatment has been shown to have therapeutic effects in patients with lumbar disc herniation [25, 28]; Giurazza et al found that O 3 therapy used for the treatment of low back pain was safe and effective and that the benefits lasted for up to 10 years after treatment [29]. Melchionda et al reported that paravertebral injections with oxygen-ozone could induce a direct improvement in radicular inflammation and pain [10].…”

The effect of lumbar spinal surgery history on intradiscal O2-O3 treatment results in patients with lumbar disc herniation

“…This factor is an important condition to be investigated in future studies because this distinction has not been made in many studies that evaluated the effectiveness of ozone therapy. [7,[10][11][12][13][14][15] The overall rate of procedural complication of ozone administration is 0.1%. [5] Two meta-analyses have identified the safety and effectiveness of this therapy.…”

Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient

“…that O 3 therapy is effective to control LBP associated to NP Herniated and/or DDD [34,[39][40][41][42][43][44][45][46][47][48][49]. The two main route of administration used were the intramuscular injection in the paravertebral muscles of the muscles innervated for the nerves of affected segments [39][40][41] and the percutaneous Intra disc injection [42][43][44][45][46][47][48][49]. Both administration route showed effi ciency to control the LBP in around 60 to 80% of treated patients with a diminishing of 60 to 75% in the VAS index.…”

“…The major cause of medical failure was and advanced degree of lumbar-sacrum osteo arthrosis related to a continuous and severe pain that lasted more than one year. Because these morphologic and clinical limitations were described by the fi rst reported treated patients [39][40][41][42][43], these 2 conditions were exclusions in the subsequent series of clinical trials [44][45][46][47][48][49].…”

“…These multifactorial effects of the Oxygen-Ozone therapy are the rational explanation for the high clinical effi cacy on chronic DDD. It is highly effective controlling, and even abolishing, the LBP [39][40][41][42][43][44][45][46][47][48][49]. The limitation of this therapy is that it does not affect fi brosis of the affected area, which is mainly composed of collagen type 1 which inhibits the re growing of new cartilage.…”