Ozone therapy with local cellular immune modulation and disc progenitor cell implant is safe, effective and efficient

Grangeat, Anibal Martin; Ea, Crocce; Erario, María A; Brandolino, M.T. Moviglia; Sl, Piccone; Ma, López; Ga, Moviglia

doi:10.17352/ojor.000023

Cited by 1 publication

(1 citation statement)

References 84 publications

(148 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Medical ozone has an antioxidant effect and modulates the immune response, specifically focused on the activated macrophages allowing the implanted cells survival. This local Immune modulation may help the CEP, subchondral bone and vertebral body repair, as well as allowing the integration of all these structures [ 79 ]. Chen et al recently documented that during the co-culture of macrophages and bone mesenchymal stem cells (BMSCs), after the macrophages were polarized from M1 to M2, the expression of pro-inflammatory factors TNF-α, IL-1β and CCR7 in BMSCs notably decreased, while the expression of anti-inflammatory factors IL-4, IL-10 and CD206 were markedly increased, the expression of osteogenesis-related molecules was increased, and the alkaline phosphatase activity was enhanced [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment

Grangeat

Erario

2023

IJMS

View full text Add to dashboard Cite

Degeneration of the intervertebral disc is one of the most frequent causes of lumbar pain, and it puts an extreme strain on worldwide healthcare systems. Finding a solution for this disease is an important challenge as current surgical and conservative treatments fail to bring a short-term or long-term solution to the problem. Medical ozone has yielded excellent results in intervertebral disc pathology. When it comes to extruded disc herniation, ozone is the only etiological treatment because it stimulates the immune system to absorb the herniated portion of the nucleus pulposus, thus resolving discal extrusion. This work aims to examine the biomolecular mechanisms that lead to intervertebral disc degeneration while highlighting the significance of oxidative stress and chronic inflammation. Considering that ozone is a regulator of oxidative stress and, therefore, of inflammation, we assert that medical ozone could modulate this process and obtain inflammatory stage macrophages (M1) to switch to the repair phase (M2). Consequently, the ozone would be a therapeutic resource that would work on the etiology of the disease as an epigenetic regulator that would help repair the intervertebral space.

show abstract

Section: Discussionmentioning

confidence: 99%