Intradermal Microdroplet Injection of Diluted Incobotulinumtoxin-A for Sebum Control, Face Lifting, and Pore Size Improvement

Park, Jeyoung; Cho, Soo Ick; Hur, Keunyoung; Lee, Dong Hun

doi:10.36849/jdd.5616

Cited by 23 publications

(48 citation statements)

References 21 publications

(36 reference statements)

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“…Treatment: BoNT‐A, often used in a hyperdiluted form, can be useful for pore tightening in patients with increased sebum production, such as acne and rosacea. 39 , 40 HA can reduce pore size, 41 , 42 and hyperdiluted CaHA 43 can improve overall skin quality that encompasses pore size.…”

Section: Consensus Results/recommendationsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“… 77 The low potential for induction of immunogenicity of INCO makes it an ideal choice for intradermal injections, which may be more immunogenic than intramuscular because of the larger number of dendritic cells in the dermis that could facilitate antigen presentation, and evolving aesthetic procedures that require larger amounts of BoNT-A. 40 Intradermal microdroplet injection of INCO was recently shown to improve facial laxity, sebum production, and pore count for up to 12 weeks after injection. 40 There was consensus that BoNT‐A is also useful for improving glow and acne scars.…”

Section: Discussionmentioning

confidence: 99%

“… 40 Intradermal microdroplet injection of INCO was recently shown to improve facial laxity, sebum production, and pore count for up to 12 weeks after injection. 40 There was consensus that BoNT‐A is also useful for improving glow and acne scars.…”

Section: Discussionmentioning

confidence: 99%

“…Intradermal injections can decrease sebum production possibly by acetylcholine inhibition and improve skin laxity and enlarged facial pores possibly by inhibiting contraction of arrector pili muscles. 40 IncobotulinumtoxinA (INCO; Xeomin ® /Bocouture ® , Merz Pharmaceuticals GmbH, Germany) may have advantages over other botulinum toxin formulations for improving skin quality because it is made by a unique two-step chromatographic purification process that yields only the pure 150 kDa active neurotoxin without unnecessary bacterial proteins and/or denatured BoNT protein, which may initiate an immune response and the production of neutralizing antibodies that can be associated with decreased effect over time or treatment non-response. 40 Further studies are needed to support this hypothesis.…”

Section: Bont-amentioning

confidence: 99%

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Skin Quality – A Holistic 360° View: Consensus Results

Goldie¹,

Kerscher²,

Fabi³

et al. 2021

CCID

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Introduction Skin quality is an important component of human attractiveness. To date, there are no standardized criteria for good skin quality. To establish a consensus for good skin quality parameters and measurement and treatment options, a virtual skin quality advisory board consisting of a global panel of highly experienced aesthetic dermatologists/aesthetic physicians was convened. Methods A total of 10 dermatologists/aesthetic physicians served on the advisory board. A modified version of the Delphi method was used to arrive at consensus. Members accessed an online platform to review statements on skin quality criteria from their peers, including treatment and measurement options, and voted to indicate whether they agreed or disagreed. Statements that did not have agreement were modified and the members voted again. Consensus was defined as: strong consensus = greater than 95% agreement; consensus = 75% to 95% agreement; majority consent = 50% to 75% agreement; no consensus = less than 50% agreement. Results There was strong consensus that good skin quality is defined as healthy, youthful in appearance (appearing younger than a person’s chronological age), undamaged skin and that skin quality can be described across all ethnicities by four emergent perceptual categories (EPCs): skin tone evenness, skin surface evenness, skin firmness, and skin glow. The EPCs can be affected by multiple tissue layers (ie, skin surface quality can stem from and be impacted by deep structures or tissues). This means that topical approaches may not be sufficient. Instead, improving skin quality EPCs can require a multilayer treatment strategy. Conclusion This global advisory board established strong consensus that skin quality can be described by four EPCs, which can help clinicians determine the appropriate treatment option(s) and the tissue or skin layer(s) to address. Skin quality is important to human health and wellbeing and patients’ perception for the need for aesthetic treatment.

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Section: Consensus Results/recommendationsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Bont-amentioning

confidence: 99%

See 3 more Smart Citations

Skin Quality – A Holistic 360° View: Consensus Results

Goldie¹,

Kerscher²,

Fabi³

et al. 2021

CCID

Self Cite

View full text Add to dashboard Cite

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Micro injection of botulinum and its effects on the skin

Lopez

Kalen

Nussbaum

et al. 2022

Dermatological Reviews

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Introduction Microbotox generally refers to the injection of small aliquots of dilute botulinumtoxinA into the dermis or the junction of the dermis and underlying musculature. This novel procedure has been popularized as a treatment to improve skin quality. Objectives The purpose of this literature review is to further the understanding of techniques and to evaluate the published outcomes in microbotox treatment. Methods We conducted a keyword search in Pubmed, Google Scholar, and the university library database, yielding 363 publications. We extensively reviewed those articles which met eligibility criteria to include evaluate microbotox and its effects on skin quality. Results While treatment parameters vary across the peer‐reviewed literature, microbotox appears to be a safe and effective treatment for improving skin quality. Benefits cited range from improving skin texture, achieving facial lifting, softening rhytids, reducing oiliness and pore size, increasing hydration, and ameliorating erythema and flushing. Conclusion Microbotox has the unique potential benefit of improving all three key determinants of skin quality: visual, mechanical, and topographical. Further research would validate and quantify its beneficial effects in the skin.

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Incobotulinum toxin A: A shelf‐stable, low‐molecular‐weight formulation

Eells

Grunebaum

Howard

2022

Dermatological Reviews

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Since its development in 2005, incobotulinum toxin A (INCO) has become one of the most widely used neurotoxins worldwide for aesthetic and therapeutic indications. It was initially designed as a formulation free of complex proteins for reduced immunogenicity with an equal action and strength profile to the original and widespread onabotulinum toxin A (ONA). Multiple trials have demonstrated equivalent efficacy. Several studies have suggested a slight decrease in the time of visible treatment onset with INCO and a subsequent lack of difference in duration of effects when compared with ONA. Particularly appreciable with therapeutic doses, utilization of INCO led to significant cost savings over ONA or abobotulinum toxin A. Karschney et al. found that for the treatment of cervical dystonia and chronic migraine the cost to patients was reduced by 32.2% compared to ONA. Additionally, the ONA formulation allows for long-term storage at room temperature along with an increased stability time once reconstituted. Limitations of INCO include a similar side effect profile to other neurotoxin formulations, more likely at therapeutic dosing. Indications approved by the Federal Drug Administration in the United States and other regulatory agencies are currently more limited than those of ONA, though this may be in direct relation to the length of time on the market. INCO has overall been demonstrated to be a safe, efficacious alternative to other common neurotoxin formulations.

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Intradermal Microdroplet Injection of Diluted Incobotulinumtoxin-A for Sebum Control, Face Lifting, and Pore Size Improvement

Cited by 23 publications

References 21 publications

Skin Quality – A Holistic 360° View: Consensus Results

Skin Quality – A Holistic 360° View: Consensus Results

Micro injection of botulinum and its effects on the skin

Incobotulinum toxin A: A shelf‐stable, low‐molecular‐weight formulation

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