Intracranial tumoural haemorrhage – a report of 58 cases

Liu, Yuguang; Li, Meng; Zhu, Shuchai; Jiang, Yuquan; Chen, Yingjie; Li, Xingang

doi:10.1054/jocn.2002.1131

Cited by 45 publications

(37 citation statements)

References 9 publications

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“…Among these cases, three patterns of hemorrhage can be distinguished: pure intratumoral, pure extratumoral (intraventricular and/ or subarachnoid), and finally those subependymomas associating signs of both intra and extratumoral bleeding. The mechanism of spontaneous intratumoral bleeding within a subependymoma remains unclear 18 . Personal antecedents predisposing to hemorrhage have only been described in the case reported by Di Lorenzo (arterial hypertension) and in our own case (anticoagulation) 4 .…”

Section: ; 21mentioning

confidence: 99%

“…Only in two cases the presence of large areas of massive intratumoral hemorrhage has been reported 7,13 . Noteworthy is the absence of these pathological findings within the cases of subependymoma associating a pure extratumoral hemorrhage, being this phenomenon considered by some authors a consequence of tearing of an ependymal or subependymal vein during tumoral growth 14,18 .…”

Section: ; 21mentioning

confidence: 99%

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Spontaneous acute hemorrhage within a subependymoma of the lateral ventricle: successful emergent surgical removal through a frontal transcortical approach

Carrasco¹,

Pascual

Navas

et al. 2010

Neurocirugía

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SummaryIntroduction. Subependymomas are benign neoplasms intimately related to the ventricular system which only exceptionally associate hemorrhagic events. We present neuroradiological and pathological evidences of intratumoral hemorrhage within a single case of subependymoma operated on at our institution. Additionally we analyze retrospectively the well-defined reports of similar cases published in the scientific literature.Case report. ResumenIntroducción. Los subependimomas son neoplasias benignas que se desarrollan en estrecha relación con el sistema ventricular y que excepcionalmente asocian fenó-menos hemorrágicos. Describimos el caso de un subependimoma localizado en el ventrículo lateral que presentó una hemorragia intratumoral aguda de forma espontá-nea, como se evidenció en los estudios neurorradiológicos y patológicos realizados, incluyendo un análisis exhaustivo de los casos similares descritos en la literatura científica.Caso clínico. Se trata de un varón de 71 años que recibía tratamiento anticoagulante, y que presentó un cuadro brusco y progresivo de disminución del nivel de conciencia. Los estudios de neuroimagen evidenciaron la presencia de una masa localizada en el ventrículo lateral izquierdo, con signos de hemorragia reciente en su seno, que producía hidrocefalia biventricular aguda. La lesión fue resecada en su totalidad de forma urgente mediante un abordaje frontal transcortical. El estudio patológico de la lesión demostró que se trataba de un subependimoma con focos hemorrágicos. En el periodo postoperatorio, el paciente presentó un déficit de memoria global, tanto anterógrada como retrógrada.Conclusiones. Los episodios de hemorragia espontánea aguda constituyen un fenómeno excepcional en el caso de los tumores de histología benigna como los subependimomas, y pueden transformar un curso clínico asintomático en una emergencia quirúrgica debido al desarrollo de hidrocefalia aguda. La extirpación completa de la lesión de forma urgente representa la opción de manejo quirúrgico más apropiada, ya que permite un reestablecimiento inmediato de la circulación de líquido cefalorraquídeo y previene la aparición de resangrado.PALABRAS CLAVE: Prosencéfalo basal. Región septal. Subependimoma. Tumor cerebral hemorrágico. Ventrículo lateral.

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Section: ; 21mentioning

confidence: 99%

Section: ; 21mentioning

confidence: 99%

Spontaneous acute hemorrhage within a subependymoma of the lateral ventricle: successful emergent surgical removal through a frontal transcortical approach

Carrasco¹,

Pascual

Navas

et al. 2010

Neurocirugía

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“…In a large analysis from a single center, 4.4% of intracerebral hematomas were related to intracranial tumors, mostly glioblastoma, metastases, anaplastic and low-grade glioma, and meningiomas [6] . In other cohorts, 1.4-15% of spontaneous ICHs are tumorassociated depending on the age of patients and the different diagnostic procedures [7] . We report a patient with acute ICH due to metastasis of a granulosa cell carcinoma with symptomatic bleeding.…”

Section: Dear Sirmentioning

confidence: 99%

“…Firstly, brain tumor bleeding is mostly related to highly vascularized and rapidly growing tumors with an imbalance of blood supply to the tumor resulting in necrosis and bleeding. A further potential bleeding cause is inva- Metastatic tumors include lung cancer, liver cancer, breast cancer, renal cell carcinoma, melanoma and different other cancer types [7] . Even rare tumor types can manifest with bleeding such as metastasis of granulosa cell carcinoma as in our case.…”

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confidence: 99%

Intracerebral Hemorrhage due to Metastasis of Ovarian Granulosa Cell Carcinoma 36 Years after Initial Diagnosis

et al. 2007

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“…6,9) The incidence of intratumoral hemorrhage depends mainly on the tumor histology and location. 2,4,10,11) Intratumoral hemorrhage can usually be identified preoperatively by imaging studies, as the border between the tumor and hemorrhage is usually clear, 3,8) but if the hemorrhage is large and expansive enough, the tumor may be compressed and thus not visualized, even if contrast material is used. Therefore, intratumoral hemorrhage may be indistinguishable from spontaneous ICH, and any delay in diagnosis may adversely affect the prognosis for the patient.…”

Section: Introductionmentioning

confidence: 99%

Glioblastoma Masquerading as a Hypertensive Putaminal Hemorrhage: A Diagnostic Pitfall -Case Report-

Inamasu

Kuramae

Nakatsukasa

2009

Neurol. Med. Chir.(Tokyo)

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A 58-year-old man presented with a rare case of glioblastoma masquerading as intracerebral hemorrhage (ICH). He had been medicated for hypertension and diabetes for 10 years before collapsing at home. Brain computed tomography (CT) showed ICH in the right putamen, but CT with contrast medium showed no underlying lesion. He was treated initially with intravenous administration of anti-hypertensive agent under a diagnosis of hypertensive putaminal hemorrhage. ICH aspiration surgery was performed, and serial CT showed ICH resorption. However, he was again admitted for unstable gait and mildly altered mental status 3 months after discharge. Magnetic resonance (MR) imaging with gadolinium showed an enhanced ring-shaped mass around the hematoma cavity. Open biopsy was performed. The histological diagnosis was glioblastoma multiforme, and he was treated with radiation therapy and oral chemotherapy with temozolomide. MR imaging showed marked shrinkage of the tumor, but he died of pneumonia 3 months after the second surgery. In this case, the cause of the hemorrhage was not identified after the seemingly successful hematoma evacuation surgery, and no definitive diagnosis was made until tumor regrowth. Brain tumor should be suspected as a cause of ICH even if the patient has a history of hypertension and the location is typical for hypertensive ICH. Clinical/radiological follow up is essential for detecting subtle neurological deterioration to avoid diagnostic delay.

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Intracranial tumoural haemorrhage – a report of 58 cases

Cited by 45 publications

References 9 publications

Spontaneous acute hemorrhage within a subependymoma of the lateral ventricle: successful emergent surgical removal through a frontal transcortical approach

Spontaneous acute hemorrhage within a subependymoma of the lateral ventricle: successful emergent surgical removal through a frontal transcortical approach

Intracerebral Hemorrhage due to Metastasis of Ovarian Granulosa Cell Carcinoma 36 Years after Initial Diagnosis

Glioblastoma Masquerading as a Hypertensive Putaminal Hemorrhage: A Diagnostic Pitfall -Case Report-

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