Intracerebral Hemorrhage due to Metastasis of Ovarian Granulosa Cell Carcinoma 36 Years after Initial Diagnosis

Heckmann, Josef G.; Tilz, Christian; Dütsch, Matthias; Blümcke, Ingmar; Hildebrandt, Michelle A.T.; Schwab, Stefan

doi:10.1159/000103647

Cited by 5 publications

(1 citation statement)

References 11 publications

(19 reference statements)

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“…Brain metastases indicate disseminated malignant disease and therapy is rarely curative 3. The dynamics of cerebral metastases are variable, sometimes with extremely long latencies—up to 36 years—between cancer diagnosis and cerebral lesion in some types of tumour 4. In lung cancer, 10–25% of patients have cerebral metastases at diagnosis and 40–50% of the patients develop cerebral metastases during the course of their disease 3…”

Section: Commentmentioning

confidence: 99%

Rapid brain metastasis within 3 weeks

2013

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A 70-year-old man with a recent diagnosis of adenocarcinoma of the lung presented with right hand clumsiness. Examination found a slight weakness of the right arm. A non-contrast cranial CT scan showed at least five hyperdense circular lesions with a diameter up to 2 cm, compatible with brain metastases (figure 1A).Twenty-two days earlier, a poorly differentiated adenocarcinoma of the lung had been diagnosed on biopsy of a mass in the left lower lobe of the lung. Staging at this time included a normal cerebral MRI (figure 1B). Positron emission tomography (PET) with fluorine 18-labeled fluorodeoxyglucose (F18-FDG PET) showed a tumour in the left lower lung and increased tracer uptake in isolated mediastinal lymph nodes but no additional lesions. Bone scintigraphy and abdominal sonography were normal. A contrast-enhanced thoracic CT scan hinted at a carcinomatous lymphangiosis of the contralateral lung. Advanced lung cancer was diagnosed and combined radiochemotherapy was initiated. 1 COMMENT The incidence of brain metastases is 10 times higher than that of primary malignant brain tumours. 2 Brain metastases indicate disseminated malignant disease and therapy is rarely curative. 3 The dynamics of cerebral metastases are variable, sometimes with extremely long latencies-up to 36 years-between cancer diagnosis and cerebral lesion in some types of tumour. 4 In lung cancer, Figure 1 A 70-year-old man with clumsiness of the right upper extremity. (A) Unenhanced axial CT scan shows at least five hyperdense circular lesions with a diameter up to 2 cm, compatible with brain metastases. (B) MRI brain scan (axial, T2-weighted) 22 days earlier in the same patient was adjudged unremarkable. At this time the patient was without neurological complaints and the examination was indicated in the staging process of lung cancer.

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Section: Commentmentioning

confidence: 99%

Rapid brain metastasis within 3 weeks

2013

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Brain metastasis from ovarian cancer: case report and review of the literature

Imitola

Kim

et al. 2011

Med Oncol

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We present an 80-year-old lady with a history of ovarian cancer, who manifested with seizure and left upper extremity weakness. The imaging revealed a multilobulated mass within right parietal lobe. She underwent surgical resection and the pathology was compatible with metastasis from ovarian adenocarcinoma. She received a whole brain radiation therapy and she has been in remission for more than 2 years.

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