Intracranial tuberculoma

Garland, Hugh; Armitage, George

doi:10.1002/path.1700370313

Cited by 48 publications

(13 citation statements)

References 8 publications

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“…According to a report published in 1933, 34% of intracranial spaceoccupying lesions in England were tubercular lesions; this proportion decreased to 0.15% in Great Britain by 1972, 6,12) indicating that the incidence of intracranial tuberculoma had rapidly decreased. However, in recent times, the number of reports linking tubercular lesions to human immunodeficiency virus (HIV) infection has increased.…”

Section: Introductionmentioning

confidence: 99%

Intracranial Tuberculoma in Non-immunosuppressive State

Matsumoto

Aikawa

Narita

et al. 2013

Neurol. Med. Chir.(Tokyo)

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The rise in the incidence of tuberculosis is generally related to human immunodeficiency virus infection. However, intracranial tuberculoma, a complication of tuberculosis considered to be a critical disease, can develop even in the absence of immunosuppressive state. Here, we describe 2 cases of intracranial tuberculoma occurring in patients with no evidence of immunosuppressive state or past history of tuberculosis. In Case 1, lesions were observed in the right lateral ventricle, with histological examination revealing granulomatous lesions. In Case 2, scattered lesions were observed in the cranium and the lung fields. In both cases, the QuantiFERON Test (QFT) was positive, and improvements were observed in the symptoms following administration of antituberculous drugs. Intracranial tuberculoma cannot be considered rare, and needs to be included in the differential diagnosis of intracranial lesions. Diagnosis can be tricky since this disease can develop in a patient in a non-immunosuppressive state or without a past history of tuberculosis. The QFT is an effective test to enable the diagnosis of tuberculomas in atypical patients.

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Section: Introductionmentioning

confidence: 99%

Intracranial Tuberculoma in Non-immunosuppressive State

Matsumoto

Aikawa

Narita

et al. 2013

Neurol. Med. Chir.(Tokyo)

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“…Before the discovery of antituberculosis drug therapy, tuberculomas represented as much as 30% of the intracranial tumors in adults and 50% in children (20). The frequency is now between 0.25% and 4% in western countries (21).…”

Section: Discussionmentioning

confidence: 99%

An Unusual Pituitary Pathology

Pétrossians

Delvenne²,

Flandroy

et al. 1998

The Journal of Clinical Endocrinology & Metabolism

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“…Os tuberculomas cerebrais são, com certa frequência, múltiplos e o número de lesões varia, sendo quase sempre inferior a 10 3-9,12, [14][15][16][17][18]20,[23][24][25][26]29,31,33,[35][36][37]39,40. Num caso relatado por Dastur et al16 havia 22 minúsculos tuberculomas cerebrais, o de maior número de lesões descrito até então na literatura.…”

Section: José Eymardunclassified

“…The patient was a chronic alcoholic and had generalized tuberculosis. The literature on multiple cerebral tuberculomas is reviewed and the neurological clinical picture presented by the patient and the association between generalized tuberculosis and chronic alcoholism arc commented upon.Os tuberculomas cerebrais representam uma das lesões expansivas intracranianas com incidência variável conforme a procedência das séries publicadas.Em países como a Índia, Nigéria, Rodésia, Chile e Brasil foram encontrados índices de 21,5% 16, 12,5%33) 19%27( 15,9%5 e 4,4% 2 5, respectivamente.As incidências menores são observadas nos Estados Unidos e Europa Ocidental, onde constituem menos de 1% das lesões expansivas intracranianas 21,34,41.Os tuberculomas cerebrais são, com certa frequência, múltiplos e o número de lesões varia, sendo quase sempre inferior a 10 3-9,12, [14][15][16][17][18]20,[23][24][25][26]29,31,33,[35][36][37]39,40. Num caso relatado por Dastur et al16 havia 22 minúsculos tuberculomas cerebrais, o de maior número de lesões descrito até então na literatura.…”

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Tuberculomas cerebrais múltiplos: relato de um caso autopsiado com 37 lesões

Pittella

Toppa

1988

Arq. Neuro-Psiquiatr.

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RELATO DE UM CASO AUTOPSIADO COM 37 LESÕES JOSÉ EYMARDHOMEM PITTELLA -NIVALDO HARTUNG TOPPA RESUMO -É descrito caso autopsiado com 37 tuberculomas cerebrais, o de maior número de lesões descrito na literatura. O paciente era alcoólatra crônico e tinha tuberculose generalizada. Faz-se revisão da literatura de tuberculomas cerebrais múltiplos e comenta-se o quadro clínico neurológico apresentado pelo paciente e a associação entre tuberculose generalizada e alcoolismo crônico.Multiple cerebral tuberculomas: report of a post-mortem examined case with 37 lesions.SUMMARY -An autopsied case of multiple cerebral tuberculomas with 37 lesions, the one with the greatest number of lesions described in the literature, is reported. The patient was a chronic alcoholic and had generalized tuberculosis. The literature on multiple cerebral tuberculomas is reviewed and the neurological clinical picture presented by the patient and the association between generalized tuberculosis and chronic alcoholism arc commented upon.Os tuberculomas cerebrais representam uma das lesões expansivas intracranianas com incidência variável conforme a procedência das séries publicadas.Em países como a Índia, Nigéria, Rodésia, Chile e Brasil foram encontrados índices de 21,5% 16, 12,5%33) 19%27( 15,9%5 e 4,4% 2 5, respectivamente.As incidências menores são observadas nos Estados Unidos e Europa Ocidental, onde constituem menos de 1% das lesões expansivas intracranianas 21,34,41.Os tuberculomas cerebrais são, com certa frequência, múltiplos e o número de lesões varia, sendo quase sempre inferior a 10 3-9,12, [14][15][16][17][18]20,[23][24][25][26]29,31,33,[35][36][37]39,40. Num caso relatado por Dastur et al.16 havia 22 minúsculos tuberculomas cerebrais, o de maior número de lesões descrito até então na literatura.Descrevemos caso autopsiado de alcoólatra crônico e com tuberculose generalizada em que foram identificados 37 tuberculomas cerebrais. OBSERVAÇÃO JPS, sexo masculino, 46 anos, alcoólatra crônico, desempregado, procedente do Hospital João XXIII, em Belo Horizonte. O paciente foi admitido naquele hospital queixando-se de cefaléia, tonteiras e diarréia. À admissão informava mal e nada lembrava de sua história pessoal pregressa. O exame físico revelou desnutrição, desidratação, icterícia, ascite e escabiose. Os exames laboratoriais mostraram provas funcionais hepáticas compatíveis a insuficiência hepática.Durante a hospitalização o paciente apresentou três crises convulsivas

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Intracranial tuberculoma

Cited by 48 publications

References 8 publications

Intracranial Tuberculoma in Non-immunosuppressive State

Intracranial Tuberculoma in Non-immunosuppressive State

An Unusual Pituitary Pathology

Tuberculomas cerebrais múltiplos: relato de um caso autopsiado com 37 lesões

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