Intracranial Tuberculoma in Non-immunosuppressive State

Abstract

The rise in the incidence of tuberculosis is generally related to human immunodeficiency virus infection. However, intracranial tuberculoma, a complication of tuberculosis considered to be a critical disease, can develop even in the absence of immunosuppressive state. Here, we describe 2 cases of intracranial tuberculoma occurring in patients with no evidence of immunosuppressive state or past history of tuberculosis. In Case 1, lesions were observed in the right lateral ventricle, with histological examination revealing granulomatous lesions. In Case 2, scattered lesions were observed in the cranium and the lung fields. In both cases, the QuantiFERON Test (QFT) was positive, and improvements were observed in the symptoms following administration of antituberculous drugs. Intracranial tuberculoma cannot be considered rare, and needs to be included in the differential diagnosis of intracranial lesions. Diagnosis can be tricky since this disease can develop in a patient in a non-immunosuppressive state or without a past history of tuberculosis. The QFT is an effective test to enable the diagnosis of tuberculomas in atypical patients.

Fabrication and evaluation of a homogeneous electrospun PCL–gelatin hybrid membrane as an anti-adhesion barrier for craniectomy

“…Reason for this phenomenon is explained by the fact that collagen was deposited around the suture thread, when the suture thread was removed the collagen was also removed, and the original needle hole appeared again. 4 For non-degradable membranes, this kind of situation is inevitable.…”

Presentation, diagnosis, and treatment of a cerebellar tuberculoma: illustrative case

“…19 Rarely, these cases can present in patients without immunosuppression. 20 This case serves as a reminder that the differential diagnosis in patients with known prior TB exposure who present with an intracranial mass suspicious for infection should include CNS tuberculoma, regardless of time since exposure, presence or absence of active disease, results of Quanti-FERON testing, and current immune state.…”

An intracranial tuberculoma case interfere with brain tumor

“…Günümüzde HIV infeksiyonu sıklığında artışla birlikte tüberküloz ınsidansında da arttış görülmektedir [1] .İntrakraniyal tüberkülomlar, tüberküloz menenjitle birlikte veya tüberküloz menenjit olmaksızın görülebilir [2].…”

“…İntrakraniyal tüberkülom tüberkülozun ciddi seyirli bir komplikasyonudur ve sıklıkla immun sistemi baskılanmış hastalarda görülür [1].…”