Fabrication and evaluation of a homogeneous electrospun PCL–gelatin hybrid membrane as an anti-adhesion barrier for craniectomy

Abstract

An electrospun PCL–gelatin membrane's excellent anti-adhesive properties, biocompatibility and adjustable biodegradable rate make it compatible for applying as an anti-adhesion barrier for craniotomy.

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

“…However, synthetic polymers lack cell affinity because of their low hydrophilicity and lack of surface cell recognition sites . To overcome this drawback, synthetic‐based materials are often functionalized prior to biological use.…”

A convenient method to fabricate porous cross-linked PCL membrane by using dual pore-forming agents

“…More importantly, the pore size of the membranes is nearly 5 μm in average, while the Eukaryotic cell diameters range from 20~30 μm [22]; the much smaller pore sizes of the membranes than the size of fibroblasts are beneficial to prevent the fibroblasts through the membranes [5]. Therefore, the membrane can be used as the anti-adhesion membranes.…”

“…Polymer porous membranes have been widely used in the field of tissue engineering materials [1,2], for examples, tympanic membrane substitute [3], anti-adhesion barrier [4,5] and skin tissue *Corresponding author: qflee@mail.buct.edu.cn (Q. Li). FAX: +86-10-64435676 engineering [6].…”

Preparation and evaluation of poly(ester-urethane) urea/gelatin nanofibers based on different crosslinking strategies for potential applications in vascular tissue engineering

“…As a result, the tensile strength of the membranes in the wet state increased. 24,29 The other two important mechanical variables to consider are the suture retention strength and the burst pressure strength, both shown in Table 2. The suture retention strengths of the PEUU nanobrous scaffolds were lower than the other specimens' values, which is attributed to the hybrid gelatin improving the stress of the composite nanobers.…”